Please or to access all these features

Feminism: Sex and gender discussions

Hilary Cass sent a document to every single MP and Peer, justifying and defending the puberty blockers trial

815 replies

SingleSexSpacesInSchools · 10/07/2026 13:28

https://x.com/JamesEsses/status/2075512549248745744?s=20

There are ten images on X, sorry can't add them all here, or upload a file with it all in.

James Esses (@JamesEsses) on X

🚨Breaking🚨 Last night, in what is significant overreach for a backbench Peer, Hilary Cass sent a document to every single MP and Peer, justifying and defending the puberty blockers trial. I have posted below the full document for people to read. He...

https://x.com/JamesEsses/status/2075512549248745744?s=20

OP posts:
Thread gallery
20
NotBadConsidering · 11/07/2026 12:56

NullaEffugium · 11/07/2026 12:53

Not a very good analogy. This is more like should we test a vaccine or a drug on children, where we know it potentially is harmful but we need to prove it is harmful to stop off-licence usage.

This is a terrible analogy. If a vaccine is potentially harmful in animal studies, it doesn’t progress to clinical trials in children. You don’t test it on children to be sure🤨

Edictfromno10 · 11/07/2026 12:56

At the end of the day she's just another doctor medicalising young people's emotional and psychological distress. Medication is all they can come up with to help that young person leave the house... I can think of several other professionals who could support such a situation without experimental drugs snd the rest. Not to mention the safeguarding concerns around a toddler being transitioned ffs.

NotBadConsidering · 11/07/2026 12:53

In order for children to NOT be infertile or sterile, puberty blockers need to be stopped, no progression to CSH, and puberty resumed to completeness.

In the real world now, this does not happen.

I am yet to see any indication that this will happen at the end of this proposed trial period.

NullaEffugium · 11/07/2026 12:53

AskingQuestionsAllTheTime · 11/07/2026 12:47

That's a bit like saying "it is not ethical to beat children with sticks, but since some parents are doing it anyway we'd better do a study to confirm that being beaten with sticks is not good for children".

Not a very good analogy. This is more like should we test a vaccine or a drug on children, where we know it potentially is harmful but we need to prove it is harmful to stop off-licence usage.

Shedmistress · 11/07/2026 12:52

Tottenhamhotflushes · 11/07/2026 11:10

What are you talking about? You suggested puberty blockers cause continuing on to cross sex hormones. I said there is no proof of that.

The records from GIDS say that. The records from many gender clinics across the globe say that. Whistleblowers say thay.

I didnt say anything.

NotBadConsidering · 11/07/2026 12:51

NullaEffugium · 11/07/2026 12:50

No that much more specific clarification isn’t wrong, I was referring to the earlier versions that stated all children who merely start on PBs will become sterile.

Edited

No one has claimed that. All children who start puberty blockers early and go on to CSH are infertile. Only the boys who do this from the earliest stages are sterile.

NullaEffugium · 11/07/2026 12:50

NotBadConsidering · 11/07/2026 12:48

It’s not a claim. It’s a fact. Boys blocked at the beginning of puberty who go onto CSH have never and never will make sperm. They are sterile. Which part of that is wrong?

Edited

No that much more specific clarification isn’t wrong, I was referring to the earlier versions that stated all children who merely start on PBs will become sterile.

NullaEffugium · 11/07/2026 12:49

spannasaurus · 11/07/2026 12:45

A statutory instrument was enacted that overrides previous privacy protections to force NHS adult gender clinics to hand over data for retrospective study.

The clinics are still not providing the data for study

Edited

I was not aware of that. Well I guess it’s a legal standoff. For the record, I would want to trust that if I checked no you can’t use my private data for research on an NHS form that that would be respected at least until my death.

If we push on this, then we are essentially allowing the NHS to share or sell our medical data with associated lifestyle and personal data without our permission from this point forward.

NotBadConsidering · 11/07/2026 12:48

NullaEffugium · 11/07/2026 12:45

Fair enough on my 100% viewpoint, I feel the same way about the 100% will be irreversibly sterile claim floating around on the thread.

Edited

It’s not a claim. It’s a fact. Boys blocked at the beginning of puberty who go onto CSH have never and never will make sperm. They are sterile. Which part of that is wrong?

AskingQuestionsAllTheTime · 11/07/2026 12:47

NullaEffugium · 11/07/2026 11:45

Yes, thank you, I wasn’t very clear. I am on the fence about the ethics of drug testing on children that are below the age of consent for medical procedures. Especially when I consider the parenting these children have.

It is not ethical to test drugs on children, but we are in a situation where it is happening anyway and the only way to stop it long term is to prove how unsafe puberty blockers really are.

That's a bit like saying "it is not ethical to beat children with sticks, but since some parents are doing it anyway we'd better do a study to confirm that being beaten with sticks is not good for children".

AskingQuestionsAllTheTime · 11/07/2026 12:46

AimsAndObjectives · 11/07/2026 11:13

@Tottenhamhotflushes So I suspect the Cass trials are carefully vetting their candidates similarly.

This is one of the points that people raise though. If Cass et al believe that they have found a way to identify children that will become 'true trans' adults, why aren't they sharing that methodology prior to the trial?

My life yes! That's as bonkers as suggesting they someone has found the cure for malaria and is keeping it under his or her hat.

spannasaurus · 11/07/2026 12:45

NullaEffugium · 11/07/2026 12:37

I am not sure what you misunderstood. There are retrospective studies done of adults on the effect of puberty blockers on their health. That is how we know about fertility risk, bone density risk, cancer risk.

As for the specific patient data from clinics being nonreleasable under GDPR because the patients refused permission for their data to be used in research that is another matter entirely.

A statutory instrument was enacted that overrides previous privacy protections to force NHS adult gender clinics to hand over data for retrospective study.

The clinics are still not providing the data for study

NullaEffugium · 11/07/2026 12:45

AimsAndObjectives · 11/07/2026 12:20

I imagine that previous, recent pb use will show up in blood tests.

I think it is likely that at least some of the parents involved in the trial will have steadfastly held out against the demands of their children to procure blockers online and would not do this under any circumstances. Your 100% claim was a bit too dogmatic for me.

Fair enough on my 100% viewpoint, I feel the same way about the 100% will be irreversibly sterile claim floating around on the thread.

TwoLoonsAndASprout · 11/07/2026 12:45

NullaEffugium · 11/07/2026 12:34

No “might” about it - they won’t mature. That is the one sure thing that we do know about PBs - they stop the normal maturation of a pubescent body, which includes the mental maturation that happens during puberty.

While they are on PBs. Once they come off them, puberty restarts, so long as they haven’t taken them for too long. In this study, girls started menstruating 1yr after they stopped PBs, and boys had normal sperm production 6 weeks after stopping PBs. https://pmc.ncbi.nlm.nih.gov/articles/PMC6626312/

It is worth noting that only in a clinical trial can doctors ensure fertility preservation. Whatever illegal, potentially too high dose versions parents are giving children is way more likely to cause sterilisation.

From my post above, from a man who has a DSD which mimics PBs:

What I’ve learned since is that when the adolescent brain is starved of sex hormones during the critical window, the damage is permanent. Autism is five times more common in people like me, ADHD several times higher, and severe intellectual disability nearly eighteen times more likely. A quarter of us never become sexually active, and three-quarters of us never have children. Executive function, attention, and processing speed are all measurably lower. I live with ADHD and learning disabilities that no amount of therapy will ever fix.

NullaEffugium · 11/07/2026 12:37

BettyBooper · 11/07/2026 12:32

No they haven't. Cass recommended it was done, the adult clinics refused to release the data. They still haven't.

I am not sure what you misunderstood. There are retrospective studies done of adults on the effect of puberty blockers on their health. That is how we know about fertility risk, bone density risk, cancer risk.

As for the specific patient data from clinics being nonreleasable under GDPR because the patients refused permission for their data to be used in research that is another matter entirely.

NullaEffugium · 11/07/2026 12:34

No “might” about it - they won’t mature. That is the one sure thing that we do know about PBs - they stop the normal maturation of a pubescent body, which includes the mental maturation that happens during puberty.

While they are on PBs. Once they come off them, puberty restarts, so long as they haven’t taken them for too long. In this study, girls started menstruating 1yr after they stopped PBs, and boys had normal sperm production 6 weeks after stopping PBs. https://pmc.ncbi.nlm.nih.gov/articles/PMC6626312/

It is worth noting that only in a clinical trial can doctors ensure fertility preservation. Whatever illegal, potentially too high dose versions parents are giving children is way more likely to cause sterilisation.

BettyBooper · 11/07/2026 12:32

NullaEffugium · 11/07/2026 12:31

Right and all of these can be caused by multiple factors, you can’t prove much of anything from retrospective study of medical records. They’ve already done this many times and it’s not even enough to convince die hard activists, you and I are convinced, we can connect the dots. But it’s not enough. You know the saying, individuals can be intelligent, but people as a mob are stupid. They will read any old thing on X or Facebook and believe the most bizarre things are facts.

No they haven't. Cass recommended it was done, the adult clinics refused to release the data. They still haven't.

spannasaurus · 11/07/2026 12:32

NullaEffugium · 11/07/2026 12:27

@NotBadConsidering
thank you for sharing your thought process, I will say that starting puberty blockers doesn’t result in instant, irreversible sterilisation. There is risk to fertility the longer they are taken, perhaps the 2 year limit is to ensure that, for example, puberty is only delayed?

Thank you for explaining why you see the suicide risk as a lie. I wasn’t saying suicide risk due solely to puberty blockers because that’s never been studied, what has been studied is suicide risk to trans young people subjected to delayed or refused gender affirming treatments which includes PBs among other treatments.

I agree with the ethics issues. I feel like what is the lesser of two evils.

There was a US supreme court case last year (possibly the year before last) where Chas Strangio for ACLU had to admit that there was no evidence that suicide rates in trans people were higher than in comparative non trans people.

NotBadConsidering · 11/07/2026 12:32

NullaEffugium · 11/07/2026 12:27

@NotBadConsidering
thank you for sharing your thought process, I will say that starting puberty blockers doesn’t result in instant, irreversible sterilisation. There is risk to fertility the longer they are taken, perhaps the 2 year limit is to ensure that, for example, puberty is only delayed?

Thank you for explaining why you see the suicide risk as a lie. I wasn’t saying suicide risk due solely to puberty blockers because that’s never been studied, what has been studied is suicide risk to trans young people subjected to delayed or refused gender affirming treatments which includes PBs among other treatments.

I agree with the ethics issues. I feel like what is the lesser of two evils.

I will say that starting puberty blockers doesn’t result in instant, irreversible sterilisation

If boys are blocked at Tanner Stage 2, and normal puberty is not allowed to resume, they don’t ever produce sperm and are sterile. Currently all children progress onto CSH, so these boys are sterile.

perhaps the 2 year limit is to ensure that, for example, puberty is only delayed?

So will puberty blockers be removed and puberty allowed to resume in this trial? Or will they all continue on them until they are eligible for CSH like currently? I don’t think anyone knows.

what has been studied is suicide risk to trans young people subjected to delayed or refused gender affirming treatments which includes PBs among other treatments.

This isn’t true either. What are you basing this on?

BettyBooper · 11/07/2026 12:31

NotBadConsidering · 11/07/2026 12:22

Forget the harms of puberty blockers.

It is not even clear what is even being treated.

What is the condition that needs PBs?

Exactly.

And look who is pushing for it.

This is not just about the harms to the children's health. This would be another cohort of children who become physically and cognitively underdeveloped adults. Adults who resemble children, are compliant like children and yet are over the age of consent.

The safeguarding risks are off the scale.

NullaEffugium · 11/07/2026 12:31

BettyBooper · 11/07/2026 12:23

Eh?

No. Medical records will show eg. Any increased cancers, bone deficiencies, overall health etc.

It might not be perfect, but it's a lot better than experimenting on healthy children, for an undefined condition because otherwise their parents will buy them illegal drugs off the black market...

Right and all of these can be caused by multiple factors, you can’t prove much of anything from retrospective study of medical records. They’ve already done this many times and it’s not even enough to convince die hard activists, you and I are convinced, we can connect the dots. But it’s not enough. You know the saying, individuals can be intelligent, but people as a mob are stupid. They will read any old thing on X or Facebook and believe the most bizarre things are facts.

TwoLoonsAndASprout · 11/07/2026 12:28

TwoLoonsAndASprout · 11/07/2026 08:22

No “might” about it - they won’t mature. That is the one sure thing that we do know about PBs - they stop the normal maturation of a pubescent body, which includes the mental maturation that happens during puberty.

There was an interview at a Genspect conference with a man who had a DSD that naturally mimicked PBs. He described his peers going through puberty while he wanted to continue playing with cars and digging in the sandbox. He also appeared - despite doctors having eventually diagnosed him as an older teen, and given him appropriate hormones - to be somewhat developmentally delayed.

Found an article written by the man I referred to above:

I have isolated hypogonadotropic hypogonadism (IHH), a condition in which the brain never sends the signal to start puberty. Without medical help I would have stayed forever pre-pubescent. My story is not just my personal history; it is a warning.

In the 1980s, my classmates shot up in height, their voices broke and they started dating and becoming independent. I did not. My legs grew long but the rest of me stayed childlike. I looked like a stretched-out little boy. I still played with He-Man figures in secret because emotionally and mentally I felt years younger than my peers. The social gap widened every year. I spent my whole school career in special education; reading is still, decades later, brutally hard for me.

At fifteen I remained at Tanner Stage 1, with no secondary sexual characteristics at all. After months of scans and tests at UCSF, the diagnosis was clear: my brain was not producing the hormones needed to trigger puberty. This was not “delayed” puberty that would eventually arrive; it was absent puberty. Without intervention, I would have had a child’s body for life. I would have had brittle bones and no sexual function, as well as the emotional maturity of someone much younger.

Doctors finally gave me testosterone in a bottle. My peers had crossed that bridge gradually years earlier. I sprinted across it as a teenager, clutching prescriptions, trying to catch a train that had already left.

What I’ve learned since is that when the adolescent brain is starved of sex hormones during the critical window, the damage is permanent. Autism is five times more common in people like me, ADHD several times higher, and severe intellectual disability nearly eighteen times more likely. A quarter of us never become sexually active, and three-quarters of us never have children. Executive function, attention, and processing speed are all measurably lower. I live with ADHD and learning disabilities that no amount of therapy will ever fix.

That same biochemical state—profound suppression of the hormonal axis—is now deliberately created in healthy children with drugs like Lupron. The Dutch protocol, on which the entire gender-affirming model rests, induces exactly what my body did naturally.

genspect.org/frozen-in-time-when-puberty-doesnt-happen/

NullaEffugium · 11/07/2026 12:27

@NotBadConsidering
thank you for sharing your thought process, I will say that starting puberty blockers doesn’t result in instant, irreversible sterilisation. There is risk to fertility the longer they are taken, perhaps the 2 year limit is to ensure that, for example, puberty is only delayed?

Thank you for explaining why you see the suicide risk as a lie. I wasn’t saying suicide risk due solely to puberty blockers because that’s never been studied, what has been studied is suicide risk to trans young people subjected to delayed or refused gender affirming treatments which includes PBs among other treatments.

I agree with the ethics issues. I feel like what is the lesser of two evils.

BridgetYourFortyDaysAreUp · 11/07/2026 12:27

Tottenhamhotflushes · 11/07/2026 11:48

Carve outs are not how medical standards work. That's why they are standards. Consistency in standards needs to be maintained across treatments.

Tottenham, a lot of these arguments have already been hashed out in the puberty blockers thread, if you're interested:

https://www.mumsnet.com/talk/womens_rights/5544415-update-on-the-puberty-blockers-trial

AimsAndObjectives · 11/07/2026 12:23

Tottenhamhotflushes · 11/07/2026 11:57

I appreciate the challenges of bias provide but I also appreciate that there have been methods in modern times to mitigate scientific bias like peer reviews, transparency, reproducibility, methodological standards & analysis. It's not as if these studies can't be scrutinised & critiqued so its in the interests of those conducting them to act according to acceptable scientific practices.

There's every incentive to produce sound work that serves to build trust in the scientific community.

Sadly, this is not borne out sufficiently in practice, as any trawl of activist sites on the internet will demonstrate.

Swipe left for the next trending thread