I would like to know WHEN Dr Upton stopped being male.
Was he male when he did his medical training?
Was he male when he married his presumably straight wife? If not, does he realise he deceived her?
When did the magical change happen? And what is it that changed? Was he always a woman?
What exact changes (apart from growing his hair and putting in earrings) occurred for him to now be an ACTUAL female?