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Feminism: Sex and gender discussions

The Olsen-Kennedy study is released - Mental and Emotional Health of Youth after 24 months of Gender-Affirming Medical Care Initiated with Pubertal Suppression

81 replies

Helleofabore · 06/06/2025 06:18

The long awaited Johanna Olson-Kennedy study

https://www.medrxiv.org/content/10.1101/2025.05.14.25327614v1

Mental and Emotional Health of Youth after 24 months of Gender-Affirming Medical Care Initiated with Pubertal Suppression

Johanna Olson-Kennedy, Ramon Durazo-Arvizu, Liyuan Wang, Carolyn F. Wong, Diane Chen, Diane Ehrensaft, Marco A. Hidalgo, Yee-Ming Chan, Robert Garofalo, Asa E. Radix, Stephen M. Rosenthal

May 16, 2025

Abstract

Background and Objectives Medical interventions for youth with gender dysphoria can include the use of gonadotropin releasing hormone analogs (GnRHas) for suppression of endogenous puberty. This analysis aimed to understand the impact of medical intervention initiated with GnRHas on psychological well-being among youth with gender dysphoria over 24 months.

Methods
Participants were enrolled as part of the Trans Youth Care United States Study. Eligibility criteria for youth included a diagnosis of Gender Dysphoria and pubertal initiation. Youth with precocious puberty or pre-existing osteoporosis were ineligible. Youth reported on depressive symptoms, emotional health and suicidality at baseline, 6, 12, 18 and 24 months after initiation of GnRHas. Parent/caretaker completed the Child Behavior Checklist at baseline, 12 and 24 months after initiation of GnRHas. Latent Growth-Curve Models analyzed trajectories of change over the 24-month period.

Results
Ninety-four youth aged 8-16 years (mean=11.2 y) were predominately Non-Hispanic White (56%), early pubertal (86%) and assigned male at birth (52%). Depression symptoms, emotional health and CBCL constructs did not change significantly over 24 months. At no time points were the means of depression, emotional health or CBCL constructs in a clinically concerning range.

Conclusion
Participants initiating medical interventions for gender dysphoria with GnRHas have self- and parent-reported psychological and emotional health comparable with the population of adolescents at large, which remains relatively stable over 24 months. Given that the mental health of youth with gender dysphoria who are older is often poor, it is likely that puberty blockers prevent the deterioration of mental health.

I will read through it later today.

Mental and Emotional Health of Youth after 24 months of Gender-Affirming Medical Care Initiated with Pubertal Suppression

Background and Objectives Medical interventions for youth with gender dysphoria can include the use of gonadotropin releasing hormone analogs (GnRHas) for suppression of endogenous puberty. This analysis aimed to understand the impact of medical interv...

https://www.medrxiv.org/content/10.1101/2025.05.14.25327614v1

OP posts:
NoBinturongsHereMate · 06/06/2025 13:23

They appear to have made a huge tower of assumptions, in the hope that nobody will notice that the conclusion perched on top is: 'A cohort that did not significantly differ from the general population remained much the same over a short period.'

The hugh dropout rate and playing up the importance of non-findings looks very much like the previous high-profile study of mental health in trans identified children. Which also found that: 'A cohort that did not significantly differ from the general population remained much the same over a short period.'

Shedmistress · 06/06/2025 13:10

So this is what they have come up with after what, a year of it being supressed and looked at by every activist researcher that could possibly re-interpret the findings?

Moremountains · 06/06/2025 12:56

Reading bits of the abstract/discussion, I'm shocked that even the authors can't spin it in a more positive (for their thesis) way. It will be interesting to see if the analyses that were pre-registered with the trial were all carried out. A 30% loss to follow up, if confirmed, is really high!

northcluegc · 06/06/2025 10:53

illogical conclusion that it's worthwhile sacrificing normal healthy development to prevent mental health worsening

The strongest statement this study should be giving is that there was no evidence that the mental health of the children surveyed worsened when taking puberty blockers for 2 years. (This is assuming that the statistical analysis they have conducted is robust - I'm not familiar with LCGM to comment on that).

They provide no evidence that the mental health of the children would worsen if they didn't take puberty blockers.

I commented earlier that they hadn't reported the drop out rate. From looking again, they report recruiting 94 children. The only place I can find the numbers followed up for the full 24 months is fairly hidden in Table 4 where they have 59 children answering the depression & suicidality questionnaire at 24 months.

This suggests they lost 35 children to follow up over the 2 years (or 37%). I would want to know why they have lost such a high proportion of their cohort over two years (and you should be suspicious that they are trying to cover it up). What happened to those kids? What was their mental health like?

thenoisiesttermagant · 06/06/2025 10:06

TwoLoonsAndASprout · 06/06/2025 09:52

JOK is also being sued for medical negligence by a young woman who she medically transitioned.

https://x.com/ForWomenScot/status/1865077398535836049

https://nitter.net/ForWomenScot/status/1865077398535836049#m

JOK is also the woman who said that if girls whose breasts she had removed changed their minds in the future, they could just go get new breasts.

You have to question the medical abilities of someone who says this.

Yes, they can get fake things that look like breasts superficially. They can't get actual breasts that have the capacity to produce milk or in any way physiologically resemble real breasts. They're 100% fake.

The study seems to have more holes than swiss cheese and their illogical conclusion that it's worthwhile sacrificing normal healthy development to prevent mental health worsening has to surely be medical malpractice? This is not the standard of evidence on risk and benefit required for any other medical intervention.

TheKeatingFive · 06/06/2025 10:04

TwoLoonsAndASprout · 06/06/2025 09:52

JOK is also being sued for medical negligence by a young woman who she medically transitioned.

https://x.com/ForWomenScot/status/1865077398535836049

https://nitter.net/ForWomenScot/status/1865077398535836049#m

JOK is also the woman who said that if girls whose breasts she had removed changed their minds in the future, they could just go get new breasts.

Pure evil

TwoLoonsAndASprout · 06/06/2025 09:52

TheKeatingFive · 06/06/2025 09:30

I doubt it.

JOK's partner is trans I believe. And I think works in the area too.

These people are so up to their neck in this. Personally, professionally, socially, politically. They can't afford to have any doubts.

JOK is also being sued for medical negligence by a young woman who she medically transitioned.

https://x.com/ForWomenScot/status/1865077398535836049

https://nitter.net/ForWomenScot/status/1865077398535836049#m

JOK is also the woman who said that if girls whose breasts she had removed changed their minds in the future, they could just go get new breasts.

https://x.com/ForWomenScot/status/1865077398535836049

TheKeatingFive · 06/06/2025 09:30

PermanentTemporary · 06/06/2025 06:56

Props to them for doing the study and publishing it, eventually.

I wonder if it keeps any of them up at night.

I doubt it.

JOK's partner is trans I believe. And I think works in the area too.

These people are so up to their neck in this. Personally, professionally, socially, politically. They can't afford to have any doubts.

Datun · 06/06/2025 09:21

The research that I would really like to see, although God knows how they'd do it, is what happens to kids' brains on puberty blockers.

It just sounds like something from a science-fiction film, where they are in suspended animation. So anything they are thinking and feeling will be forever that of an 11-year-old.

DeanElderberry · 06/06/2025 09:21

This 'the treatment will prevent something happening in a future that we know nothing about' seems very similar to the poster insisting they knew that 'this happened in the past and nobody knew about about it' on another thread.

Fairies, ghosts, UFOs, and alien abductions. Goodbye reality, goodbye truth.

Datun · 06/06/2025 09:19

ArabellaScott · 06/06/2025 06:43

Discussion:

'Prior findings suggest that youth with gender dysphoria who have access to puberty blockers either demonstrate improved mental health or experience neutral effects, potentially preventing worsening mental health related in part to gender dysphoria.[9–11, 23] The results presented here are consistent with the prior literature and demonstrate that the mental health of youth as reported by both themselves and their parents/guardians is relatively stable from baseline over 24 months after starting medical intervention with GnRHa.

Depression commonly accompanies gender dysphoria and has been routinely reported as higher among youth with gender dysphoria than the population of youth at large.[24, 25] In the Youth Risk Behavioral Health Survey (YRBS) from 2021, 23.5% of middle school students reported that their mental health was not good “most of the time” or “always.” [26]

While it is not certain how “most of the time” or “always” translates to BDI-Y moderate or severe ranges, it is reasonable to assume these offer acceptable proxies, suggesting that at both baseline (18%) and at 24 months (22%), the proportion of our sample with poor mental health is no greater than that described in the general population.

National studies also report that among middle school youth, suicidal ideation, plans and attempts have continued to increase over time. In 2019, 22.3% of middle school youth reported ever thinking about suicide, 14.7% reported ever making a suicide plan, and 9.3% reported ever attempting suicide in their lifetime.[27] Suicidality is a major concern for all youth, but particularly among sexual and gender minoritized youth including those who identify as TNB.[28] Among our participants at baseline lifetime suicidal ideation, plan and attempts were comparable to those of the general population, and after 24-months following initiation of medical intervention with GnRHa, were lower than the national average.

Among the constructs assessed within CBCL, most showed no significant change over time. It is important to note that the means reported across the entire sample were not in a clinically concerning range at any time point. Rule-breaking behavior demonstrated a statistically significant decline (improvement) over time. Because the mean reported for rule-breaking behavior was not clinically concerning at any time point, the clinical significance of this change is unclear.'

In 2019, 22.3% of middle school youth reported ever thinking about suicide, 14.7% reported ever making a suicide plan, and 9.3% reported ever attempting suicide in their lifetime.

Fucking hell, nearly 10% of 11 to 14-year-olds have tried to kill themselves??

LeftieRightsHoarder · 06/06/2025 09:02

BettyFilous · 06/06/2025 06:23

Given that the mental health of youth with gender dysphoria who are older is often poor, it is likely that puberty blockers prevent the deterioration of mental health.

Well, that’s one way of framing those results. Now let’s have a conversation about risk-benefit and explore whether the same non-outcome could be achieved or bettered by talking therapies which do not leave a child developmentally stalled and sterile.

Yes indeed.

DrBlackbird · 06/06/2025 08:55

Agree with @Seethlaw that this conclusion it is likely that puberty blockers prevent the deterioration of mental health is doing a hell of a lot of heavy lifting.

SaraJon · 06/06/2025 08:24

This reply has been deleted

This has been deleted by MNHQ for breaking our Talk Guidelines.

northcluegc · 06/06/2025 07:42

This is a pre-print so worth pointing out that it hasn't been peer reviewed.

Just from a quick read through, there's a lot to critique about this. It's essentially a survey every 6 months for 2 years of kids who have started puberty blockers. Did they have any drop outs from the surveys? Did any kids stop taking puberty blockers in that time? Why does their analysis not match up to the protocol?

This says a lot really:
Recognizing the limitations in fully capturing the diversity of gender identities among TNB (trans and non-binary) individuals, the sample was categorized and stratified based on DSAB (designated sex at birth) to facilitate analysis

WarriorN · 06/06/2025 06:58

MH was poor, PB did nothing to alleviate it. Ffs

WarriorN · 06/06/2025 06:57

BettyFilous · 06/06/2025 06:23

Given that the mental health of youth with gender dysphoria who are older is often poor, it is likely that puberty blockers prevent the deterioration of mental health.

Well, that’s one way of framing those results. Now let’s have a conversation about risk-benefit and explore whether the same non-outcome could be achieved or bettered by talking therapies which do not leave a child developmentally stalled and sterile.

my immediate thoughts, talk about twisting the results.

PermanentTemporary · 06/06/2025 06:56

Props to them for doing the study and publishing it, eventually.

I wonder if it keeps any of them up at night.

Igneococcus · 06/06/2025 06:56

ArabellaScott · 06/06/2025 06:52

On the effects of covariates section, age had significant impact, also:

'Designated sex at birth was a significant predictor of baseline withdrawn depressed scores β= −4.58, 95% CI: (−8.08, −1.13), with those assigned male at birth having significantly lower baseline mean withdrawn depressed scores than those assigned female at birth. In addition, designated sex at birth was a significant predictor of change in several domains of the CBCL. '

Funny how those who "designated" the babies' sex at birth managed to put them into two distinct boxes which showed significant differences. If the sex at birth designations were as random as the word suggests this wouldn't happen.

ArabellaScott · 06/06/2025 06:54

Sex differences in gender treatment seems a screaming anomaly.

ArabellaScott · 06/06/2025 06:53

If that study shows one thing, it's sure as fuck that sex matters.

ArabellaScott · 06/06/2025 06:52

On the effects of covariates section, age had significant impact, also:

'Designated sex at birth was a significant predictor of baseline withdrawn depressed scores β= −4.58, 95% CI: (−8.08, −1.13), with those assigned male at birth having significantly lower baseline mean withdrawn depressed scores than those assigned female at birth. In addition, designated sex at birth was a significant predictor of change in several domains of the CBCL. '

OP posts:
ArabellaScott · 06/06/2025 06:50

I'm afraid you probably really do, Igneo.

Igneococcus · 06/06/2025 06:47

Depression commonly accompanies gender dysphoria and has been routinely reported as higher among youth with gender dysphoria than the population of youth at large.

Do I really have to bring out the good old "correlation is not causation" ?

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