Hollywood accounting is notoriously obscure and sometimes it's hard to know what the budget really is. But the production budget doesn't cover marketing and distribution costs, so a usual rule of thumb is that a film has to make 2.5 times its budget at the box office before the studio starts to turn a profit.
There's a big problem at the moment of budgets becoming too bloated, especially with so much investment in the superhero genre that audiences are starting to tire of. Some blockbusters (the last Indiana Jones) were so ridiculously expensive that even if audiences were interested in seeing them, it was almost mathematically impossible for them to be profitable.
The whole thing's overdue for a correction. For some reason, nobody makes mid-budget films any more, like romcoms that are pretty cheap once you've paid your stars. Even Disney can only absorb so many mega-budget flops.