Mounjaro / Wegovy with > 5st / 30kg to lose

[VelociraptorsVelociRapping]

I know, yet another Mounjaro / Wegovy thread, but I wondered if anyone else with a lot to lose would be interested in a safe space to chat. The other threads (both the long-runner and the newbies) are great but I can’t believe how relatively little some people have to lose. I know it’s all relative, and two stone can be a lot of extra weight on a small frame, and it’s great that they are doing something for their health before they end up in the same position as me… but in my more ungenerous moments I think about what a dream it would be to be ‘only’ two stone overweight, and wonder how many posters I will see come and go while I plod along.

So, if any of that resonates and you don’t think I’m an utter cow for having these thoughts, come and chat! I will start. I don’t feel comfortable sharing my current weight but am happy to say that my starting BMI is over 40 and I have 7.5 stone / 47 kg to lose. I’m very tall but there’s no kidding myself that my current situation isn't very unhealthy indeed.

I’m halfway through my second week on 2.5mg Mounjaro and so far I have lost 8lb. I have not really had many side effects apart from occasional loose stools, but I am also not experiencing the significant appetite suppression that others describe. Right now I am finding MJ a useful tool to take the edge off while I count calories and keep an eye on my macros to keep my protein intake up. A very welcome effect is that it has completely removed any desire to drink alcohol, which is helpful as a fondness for wine is part of how I got so fat in the first place. Nevertheless I am looking forward to moving up to 5mg and hopefully experiencing more appetite suppression.

Anyone else?

@frecklejuice I had no side effects on the 2.5, 5 or 7.5mg. Felt a bit queasy on the 10mg for a few days after my first dose though.

Hopefully you won't have any effects from moving up.

I had no significant SEs on 2.5 and 5 has been the same (approaching 3rd jab). Bit of muscle ache in legs on 2nd day, which I get everytime, and great appetite suppression. Weight loss is still 2-4lbs a week

I'm sorry to say that I had an awful time on my first week of 5mg. I think it is quite common because in relative terms it's the biggest jump - it's the only point at which the dose doubles. I considered counting clicks to try and mitigate the effects but in the end I carried on with the full 5mg. It settled down after about a week but it was rough while it lasted! Hopefully your experience will be smoother.

I also found the jump to 5 hard and it didn't settle down until nearly the end of the pen. I had a few days of misery every week, but they got shorter in duration as time went on and I coped.

Thanks everyone, seems like complete luck then!! I'll enjoy this last week and see what next week brings me.

Can I ask what kind of side effects you had @VelociraptorsVelociRapping @KeepingUndercover?

I was nauseous a lot, just felt super sick like when I had pregnancy sickness. Sulphur burps were the worst bit. I did actually throw up once but literally only once so that wasn't so bad. It was the two to three days of nausea and the burps that were tough.

@frecklejuice It started as strong nausea like the worst of my first trimester pregnancy sickness for about a day, and then faded to a very very strong food aversion. At one point I forced myself to eat a protein yoghurt and it took me hours to get it down, but I had to eat something as I was becoming very faint. It probably lasted about three days and then improved.

Urgh nausea is the worst! I tried Ozempic before this and it didn’t agree with me at all and the nausea was awful. I’ll hope for the best and push through because it’s definitely working so 🤞🤞

Has anyone done 6 smaller doses on their first 5mg pen to make it less of a jump? I’m really worried about moving up as I have a very busy 6 weeks (summer hols, lots of swimming, beach trips, walking, camping weekends etc) and I can’t afford to be suffering with bad side effects!

I haven't @NewoIkkin but there are people on the main thread who have - counting clicks to dose at 3.75mg instead.

Thanks! I’m thinking about six doses of 3.333 to get me through the summer holidays, then moving up to 5mg in September. It partly depends on how I do on 2.5 though.

When I have been worried about getting side effects or being too appetite suppressed for things I am doing with friends who don't know I am taking Mounjaro I have split the dose eg take 2.5mg on Monday morning and then another 2.5mg of Thursday night. You get two smaller spikes in your dose which minimises the side effects and spikes in suppression but are still on the full dose for that pen.

Then if you feel confident it isn't causing you problems you can bring the two half doses closer together till you are ready to take it all in one go. Most people do manage fine as the dose increases so you might be worrying about nothing.

So I finally mentioned it to DH tonight…. I had a very scary experience with preeclampsia when we had our son last year and I kind of framed it that losing weight would help reduce the risk of it occurring when we try for our second (which is very true!) and he said if I think it will help then to give it a go!

so on that… who does everyone recommend to get it from first time?

My 3rd jab tomorrow on 2.5.

Feeling much better about it, first week was a slog with brain fog, fatigue and some dull headaches but week 2 no side effects. I am nervous to jump to 5 so I might split the doses for the first week.

Started a diet and went from 110.2 - 106.1 and then started MJ.

SW - 106.1
CW - 103.3
Total loss - 2.8kg - over 6lb in 2 weeks!

@NewoIkkin I did 2x 3.75mg then a 4mg then moved up to 5mg. No side effects doing this way but did have major suppression the first morning after the 5mg, calmed down the following day though. I also did the injections in my thigh for the step up doses. Not sure if it helped but I wanted you to minimise the side effects.

Just to say you can do this! I started at 289lbs and this morning weighed in at 244lbs after 12 weeks on MJ. Officially in the 30’s of BMI for the first time since having my first daughter 8 years ago. This medicine has been a total game changer for me and I’ve never felt more like I’m actually going to sort my weight out once and for all. My goal weight is slightly higher than yours, I think I’d be happy around 180lbs but who knows with this medicine. Good luck!

I did a bonus dose of around 3mg from my 2.5 pen and that hit me quite hard so I will definitely be stepping up slowly to 5mg.

I've just taken the plunge and ordered with Zava!

I feel so apprehensive but excited too..

Here's my code if anyone wants to use it!!
REF4U5JP

@livingwithpmdd thats interesting about trying the thigh for the injection actually, thank you!

Does anyone know, if I were to push my dose back two days and inject on Sunday instead of Friday, would I then be able to continue the following Friday (a gap of five days), or would I have to switch my injection day to Sunday?

I titrated up slowly - I did 2 x 3.33mg 1 x 4mg and then 5mg. Worked great for me with minimal side effects.

@Alicewondersalot thanks, this is definitely something I’m considering! Did you then do another pen of 5mg doses before moving up to 7.5?

Yes 👍🏼 the 1st 3.33mg was the bonus from the 2.5mg pen and then I got 3.33mg, 4mg and 4 x 5mg from the 5mg pen and I’ve just started the next pen on 5mg last Friday. I also found that this week I’ve had the most suppression for some reason. So sticking with 5mg for the moment.

Hi all

I went up to 1mg last Wednesday.

Today I'm hungry but I can't face the thought of food... again.

Emotionally this is harder than I thought.

No advice needed, just needed a moan because I know you'll all get it!

Omg ladies. I had a "flush" that everyone talks about. I was just moaning last week that my weight got stuck for the last couple of weeks, and all of a sudden 2kg is gone in a matter of 4 days. That is 6.5 weeks on MJ. Aware it can still fluctuate, but yay anyway.
To be fair to me, I did a lot of cycling over the weekend so probably burnt quite a few calories, and perhaps the hot weather had kept me bloated too.
SW 108.3kg
CW 100.5kg
On the downside, I am going on holiday tomorrow for few days, so need to find that balance of enjoying yet not overindulging.

That's great @oreo2024 - and super losses overall in 6.5 weeks!

I've always called this a 'whoosh' - such a good feeling!