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AIBU?

Share your dilemmas and get honest opinions from other Mumsnetters.

Good god it happened to me

206 replies

hamadryad · 12/12/2025 22:39

Sorry, this seems very alarmist. But I am horrified by what has happened. I realize fully that this is a first world problem. I started mouranjo in February for various health reasons, one of which I was obese. Well the pounds flew off me at a freakish speed, so much so that my Dr told me to stop 7 weeks ago- which I did. Here is the problem. I HAVE NEVER GOT MY APPETITE BACK. I am now classed as underweight. I have absolutely no interest in food and have to force myself to eat. I now have very low blood pressure. This is a nightmare. Am I just going to shrink away? I’m living off protein and meal replacement shakes because I find it so hard to swallow food. And part of me feels like I deserve it. I’m catholic. Wil it end? Does anyone else know of this happening?!!! Is it my fault?

OP posts:
ShawnaMacallister · 13/12/2025 15:37

Littlebuddh · 13/12/2025 15:37

I fear in a few more years, alot of women are going to come forward with problems due to the skinny jabs.
And really expose the real truth that wasn't giving to them in the first place.
Same as fillers and botox.

Some story's are already out there.
And it's just awful.

😂 don't worry about us, we will be fine

User5306921 · 13/12/2025 16:15

Frequency · 13/12/2025 14:33

Why wouldn't people believe it? It is a known but very rare side effect of GLP-1s. That's not to say it shouldn't be available to people who need it, but they should be aware of the potential side effects.

The cultish defense and obsession with GLP-1s is odd and worrying. It is a medication with potentially life-threatening side effects, not the second coming.

The benefits of it need to be weighed up against the side effects. It should only be used for people whose health is at serious risk from obesity, not for those who need to lose a couple of stones.

I tend to agree. Like everything else, there are negatives and the medium to long term cost of taking the meds is still being found out. If the alternative is health risks associated with obesity then they are worth taking but taking them to drop a stone or two is crazy.

elfendom1 · 13/12/2025 16:19

ShawnaMacallister · 13/12/2025 15:13

It's not though. Long term gastroparesis or appetite loss following cessation of GLP1s isn't evidenced.

It is very well documented and you must be choosing to cherry pick the research papers if you are ignoring that. OP is only off the drug 7 weeks, we are not talking longterm, so hopefully all will settle.

ShawnaMacallister · 13/12/2025 16:23

elfendom1 · 13/12/2025 16:19

It is very well documented and you must be choosing to cherry pick the research papers if you are ignoring that. OP is only off the drug 7 weeks, we are not talking longterm, so hopefully all will settle.

Where is the evidence of long term gastroparesis or loss of appetite after stopping GLP1? A poster has posted an article above but it doesn't evidence that. I'm honestly looking and I can't see any evidence of that claim.

NikkiPotnick · 13/12/2025 16:50

Littlebuddh · 13/12/2025 15:37

I fear in a few more years, alot of women are going to come forward with problems due to the skinny jabs.
And really expose the real truth that wasn't giving to them in the first place.
Same as fillers and botox.

Some story's are already out there.
And it's just awful.

Yes you definitely sound fearful. As opposed to, say, hopeful.

elfendom1 · 13/12/2025 17:42

ShawnaMacallister · 13/12/2025 16:23

Where is the evidence of long term gastroparesis or loss of appetite after stopping GLP1? A poster has posted an article above but it doesn't evidence that. I'm honestly looking and I can't see any evidence of that claim.

Just go on the relevant scientific/medical research paper websites. If you are going to make statements, surely you know how to do this, plenty there for you. I am not here to give you a lesson on how to look up research papers. Maybe consider the word long-term also. What is your definition?

Hottoffeesauce · 13/12/2025 17:47

Have you had any other illnesses? I’ve been on jabs since January and lost 6 stones. I’ve had a couple of ‘lurgeys’ in Oct and Nov and now can’t really taste much and definitely don’t fancy food at all. I presumed it was the suspected Covid/virus/flu like bugs I’ve had.

NikkiPotnick · 13/12/2025 17:48

User5306921 · 13/12/2025 16:15

I tend to agree. Like everything else, there are negatives and the medium to long term cost of taking the meds is still being found out. If the alternative is health risks associated with obesity then they are worth taking but taking them to drop a stone or two is crazy.

Important to be aware that for a significant minority of women, two stone is the difference between an obese and healthy BMI. It's not some minor amount.

ShawnaMacallister · 13/12/2025 17:51

elfendom1 · 13/12/2025 17:42

Just go on the relevant scientific/medical research paper websites. If you are going to make statements, surely you know how to do this, plenty there for you. I am not here to give you a lesson on how to look up research papers. Maybe consider the word long-term also. What is your definition?

I've googled, I've done an AI deep research request and found nothing. Since you aren't providing any evidence of your claim you are the one making specious statements. The onus is always on the person making the claim to provide the evidence - surely you know that? The only statement I've made is that there is no evidence apparent that supports the claim that long term gastroparesis or loss of appetite is a known effect of GLP1s. I'd welcome evidence to the contrary but the only paper provided so far does not evidence that claim.

Long term would be in line with chronic illness which is defined as being of a year duration or longer.

elfendom1 · 13/12/2025 18:00

ShawnaMacallister · 13/12/2025 17:51

I've googled, I've done an AI deep research request and found nothing. Since you aren't providing any evidence of your claim you are the one making specious statements. The onus is always on the person making the claim to provide the evidence - surely you know that? The only statement I've made is that there is no evidence apparent that supports the claim that long term gastroparesis or loss of appetite is a known effect of GLP1s. I'd welcome evidence to the contrary but the only paper provided so far does not evidence that claim.

Long term would be in line with chronic illness which is defined as being of a year duration or longer.

Edited

Just stop. You made the claim, just because you don't know how to research, that is not my problem, why should people 'provide' you papers. Again to point out, OP is off the drug 7 weeks, so why are you harping on about long term.

ShawnaMacallister · 13/12/2025 18:01

elfendom1 · 13/12/2025 18:00

Just stop. You made the claim, just because you don't know how to research, that is not my problem, why should people 'provide' you papers. Again to point out, OP is off the drug 7 weeks, so why are you harping on about long term.

Oh my word, you're rude
I started to explain myself but actually I can't be arsed

Ladygodalmighty · 13/12/2025 18:27

ShawnaMacallister · 13/12/2025 11:46

Sharon Osbourne must be a medical marvel since long term appetite loss isn't a physiologically possible side effect of glp1 use

Apparently it can be. She said she stayed on it longer than she should have, losing 45 pounds. Its affected her metabolism and no matter how much she eats she can't gain any weight. Her doctor says her metabolism will recover given time.

ShawnaMacallister · 13/12/2025 18:28

Ladygodalmighty · 13/12/2025 18:27

Apparently it can be. She said she stayed on it longer than she should have, losing 45 pounds. Its affected her metabolism and no matter how much she eats she can't gain any weight. Her doctor says her metabolism will recover given time.

But this is just not possible. It's not how the drug works and it's not how metabolism works. Just because Sharon O is claiming this hardly means it's fact.

EvieBB · 13/12/2025 18:32

themerchentofvenus · 13/12/2025 14:04

Gluttony is the sin in Catholicism.
Taking a drug to 'undo' this sin would be potentially seen as cheating in the eyes of God and therefore punishable.

(I'm not religious but come from a catholic background)

((Apologies for this massive essay lol....))

Crazy isn't it? I was brought up Catholic...and ended up needing counselling in my 20s to undo some of the psychological damage it caused!! It makes me so angry to think of the utter crap we were fed and the associated unnecessary guilt we felt about being bloody human!

Religion is so clearly outdated and ignorant....and has no place in today's society (imho). Don't get me wrong, I actually believe in God, just not man-made outdated religious dogma.

Gluttony, I believe, is physiologically driven. Physiological traits can be inherited as well as being altered by trauma (trauma literally alters the neurochemistry of the brain). The fabulous Kathleen DesMaisons and her book 'Potatoes Not Prozac and website: www.radiantrecovery.com helped me to understand that more clearly and help shed any guilt surrounding my (at times) overwhelming sugar consumption. It also gave me strategies to quieten that urge. DesMaisons explains sugar (and other) addictions . Her philosophy is that we are not only at the mercy of our physiology but that trauma also shatters our serotonin system which can lead to us (understandably) searching for comfort to quieten emotional pain (even if that's subconscious pain). I'm sure many of us can relate to pain being (temporarily) soothed in the form of food and/or sugar and/or alcohol it can also be gained in the form of gambling, sex, shopping, or even over-cleaning. Basic anything that is 'extreme'. I now (happily) have zero guilt around 'gluttony'/'greed' if I lapse....and tend to be much kinder to myself rather than internally beating myself up. Some people have extremes. Some of us are 'greedy' if you want to call it that. Some aren't. Some of us have a high sex drive. Some of us don't. Some of us are alcoholics. Some of us aren't. It's not a bloody moral failing....and it's not about willpower. It's about genetic predisposition in form of our physiology and/or experience of trauma...(whether that be in the form of adverse childhood experiences or adult trauma)

The introduction of Ozempic/Mounjaro/Wegovy has just made me feel even less guilty about my overeating, in that it's clear to me that slim people may also have won the genetic lottery in that they produce sufficient GLP-1 in their brains (or guts) or wherever it is produced in the body not to feel as overwhelmingly hungry and therefore do not overeat compared to those of us who do not have sufficient supplies produce within our bodies. I finally feel vindicated. My skinny friends have never dieted and simply don't have the obsession around food that I do...because their physologiy is more genetically blessed and they naturally produce sufficient GLP-1 so they just aren't drivne to eat to the same extent.

So for a God to 'punish' you for actually taking positive steps to support your body/brain with something that it is lacking in, is akin to punishing a diabetic for taking insulin. That's a crazy religious take on 'God'

Don't get me wrong, I do think you have to take responsiblity for trying to fix as much as is possible within your capabilities. I think it's vitally important to adopt healthy eating as much as possible - I was brought up with plenty of veg and salad and fruit and wholegrains (my parents are/were Polish) and I don't understand this aversion to veg that I see amongst a lot of English kids (my daughters seem to be the only ones in their class that like salad), but by the same token, we also liked and like to eat lots of white carbs, cake, chocolate, sweets and biscuits. My saving Grace is that I'm not bothered about alcohol....but sweets are my alcohol in a different form, so absolutely no judgement here.....

Ladygodalmighty · 13/12/2025 18:37

ShawnaMacallister · 13/12/2025 15:10

The conclusion of this study is as follows

Conclusions There is an increased incidence of gastroparesis among individuals with obesity without T2D who are using semaglutide as compared with bupropion-naltrexone and sleeve gastrectomy

That doesn't say anything about long term gastroparesis following cessation of the drug which is what is being claimed.

Are you involved with selling it ShawnaMacallister? Me thinks you dost protest too much 🤔

ShawnaMacallister · 13/12/2025 19:16

Ladygodalmighty · 13/12/2025 18:37

Are you involved with selling it ShawnaMacallister? Me thinks you dost protest too much 🤔

What a fucking stupid comment

Xmasdemon · 13/12/2025 19:39

Why would you deserve it ? I think I would quite like getting really skinny and not being hungry. That's the way I used to be before I got on psych meds

Aluna · 13/12/2025 19:58

ShawnaMacallister · 13/12/2025 17:51

I've googled, I've done an AI deep research request and found nothing. Since you aren't providing any evidence of your claim you are the one making specious statements. The onus is always on the person making the claim to provide the evidence - surely you know that? The only statement I've made is that there is no evidence apparent that supports the claim that long term gastroparesis or loss of appetite is a known effect of GLP1s. I'd welcome evidence to the contrary but the only paper provided so far does not evidence that claim.

Long term would be in line with chronic illness which is defined as being of a year duration or longer.

Edited

Deep AI research 😂

HorseyOver40 · 13/12/2025 20:10

Mine came back with time.

ShawnaMacallister · 13/12/2025 20:13

Aluna · 13/12/2025 19:58

Deep AI research 😂

Do you know what AI deep research mode is 🙄

Aluna · 13/12/2025 20:21

ShawnaMacallister · 13/12/2025 20:13

Do you know what AI deep research mode is 🙄

I can see what you mean by it.

Frequency · 13/12/2025 20:24

I don't understand why people get so defensive every time the side effects or safety concerns about these medications are discussed. It is an observation about the medication, not a moral judgement against the users.

There is no other medicine in the world that elicits this type of cultish defense. I use steroid inhalers. I don't get offended when people talk about the side effects.

therearesigns · 13/12/2025 20:26

Is there a medication in the world that doesn't have the potential for serious side effects? I think they all do. They happen to someone. Yet people seem extra keen to defend this medication. Not sure why.

ABeerInTheSunshineMakesMeHappy · 13/12/2025 20:29

Leo800 · 13/12/2025 12:17

Oh dear. Sense of humour failure 🙄

🙄 indeed. The post you replied to was being sarcastic.

user1473878824 · 13/12/2025 20:31

MamaToABeautifulBoy · 12/12/2025 23:26

I’m Catholic, and there’s absolutely no theological basis for feeling guilty about weight-loss drugs. If they were a sin, they’d at least get a passing mention somewhere between Leviticus and Revelations.

Oh my god everyone she was just making a light hearted comment about catholic guilt

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