Good to read everyone's updates and welcome to our newcomers.
@GnomeDePlume sorry to read about the family history of dementia. It's another factor for me as I felt I was starting to lose words etc. Not been checked out.
Here's that New England Journal of Medicine paper reporting that tirzepatide (Mounjaro) is superior to semaglutide (Ozempic) for weight loss and waist reduction.
"A total of 19.7% of the participants in the tirzepatide group had a reduction in body weight of at least 30% (an exploratory end point) as compared with 6.9% of those in the semaglutide group, which indicated that the likelihood of meeting this weight-reduction target with tirzepatide was 2.8 times as high as that with semaglutide (Table 2). In both trial-treatment groups, the weight reduction was approximately 6% greater among women than among men."
Change in waist circumference from baseline to week 72 was 18.4 cm down (7 inches) with tirzepatide and 13.0 cm down with semaglutide (5 inches).
https://www.nejm.org/doi/full/10.1056/NEJMoa2416394 - sign up for a free acount to read 2 papers a month.
archived - doesn't have the graphs https://archive.ph/gpOMF
If I shed 30%, that'll be 93lbs, and I'll be 15 stone 7lbs. My waist will be 37 inches (currently 44 inches) if down 7 inches in line with the research findings. That seems to be size 20-22 - and I'd like to be size 14-16. So a bit confusing. When I did a vlcd, I got to 14 stone and wore mostly size 16s, a few 14s and some 18s. I felt great. I didn't have bad lipoedema then - so I'm guessing I'll carry more weight in lower legs than I did then.
So I would like to get that 100lbs within 18 months, if all continues to go well, and my skin retracts. I'm shedding slowly so think it'll be longer than that.