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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

Jan 25 starters Thread 6. Set points, baggy trousers and all the ups and downs

963 replies

Thelittlestranger · 16/03/2025 08:50

Didn't want to lose you all, so have started a new thread.

Roll up, roll up!

OP posts:
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19
TheCatsBlanket · 30/03/2025 20:45

HeavyHeidi · 30/03/2025 20:28

I eat a lot of prunes - according to some studies, also good for bone health. Guess you've already tried that?

That’s one thing I haven’t tried to be honest, I’ve never fancied them but it looks like I’ll have to buy some tomorrow. Dried or canned though or doesn’t it matter ?

discov · 30/03/2025 20:50

I swear by drinking enough water, prunes (I buy a pouch of dried ones from Lidl but they are quite squishy rather than dry!), flaxseed, chia seeds and a psyllium husk tablet every day. I do have the odd sachet of fybogel if things are feeling a bit stuck but it’s not been too bad so far.

The main thing I notice is if I’m slacking on the water front - it makes a huge difference.

HeavyHeidi · 30/03/2025 21:45

dried, I also prefer the squishy ones. And squishy dried figs help as well.

Jins · 30/03/2025 21:49

All this talk of fibre is giving me flashbacks 🤣

Before I had an appointment with my lovely understanding consultant I used to be told to increase fibre to the point that I thought I’d explode. For the vast majority of people an increase in fibre works and works well. For oddities like me it has the opposite effect. So if you’ve been bunged up for ages and have been increasing fibre to no effect it might actually be time for a mild laxative or a stool softener like docusate sodium. Movicol is useful as well.

Pandora71 · 30/03/2025 21:51

@Thelittlestranger @DGonMJ @2025istheyeari @myladyjane @Jins @MananaMananaPenelope @MJalltheway

Thanks for the holiday advice. I feel a lot of relief just deciding to pause for a bit. I’ve got enough in the fridge that I can just start again, perhaps lowering the dose and building back up again. I’ll try and eat mindfully and keep my protein up while I’m away. Wish me luck!

Whisperingdevil · 30/03/2025 22:04

Has anyone ever topped up a bit in between official injection days? Not feeling much suppression and wonder if just a little top up might help. I was due to go up to 7.5 on Thursday but only went up to 6.7, so I could just make up the difference. Or does
that confuse your system??

AmythestBangle · 30/03/2025 23:01

@TheCatsBlanket someone suggested dates on another thread and they do seem to help. I have four every morning. I like them better than prunes (and prunes/prunes juice give me terrible wind!). For a really bad acute situation (which I was in a couple of weeks ago) Laxido did the trick. Three sachets a day for two days and everything was fine. It's too strong to take all the time though, for me anyway.

HeavyHeidi · 31/03/2025 05:48

@Whisperingdevil I have not, but was just thinking the same, did not have much suppression over the weekend. Of course it could just be the weekend, I find weektime much easier.

MananaMananaPenelope · 31/03/2025 07:10

Well 🤯 weight still on the increase here, I seem to have gained 2kg in a week of eating just short of 7000 cals in total. I’m now at a weight last seen on 8th March, FGS.

Calories in and calories expended right? 🤯🤯🤯🤯

To cap it all off I’ve got a pounding headache from the food I ate last night. I had grilled tandoori chicken with salad and a heaped spoonful of DC1’s biryani. Drank water. I reckon there was some food colouring somewhere as my head was pounding within an hour of eating.

0ncemorewithfee1ing · 31/03/2025 07:37

MananaMananaPenelope · 31/03/2025 07:10

Well 🤯 weight still on the increase here, I seem to have gained 2kg in a week of eating just short of 7000 cals in total. I’m now at a weight last seen on 8th March, FGS.

Calories in and calories expended right? 🤯🤯🤯🤯

To cap it all off I’ve got a pounding headache from the food I ate last night. I had grilled tandoori chicken with salad and a heaped spoonful of DC1’s biryani. Drank water. I reckon there was some food colouring somewhere as my head was pounding within an hour of eating.

Well, that doesn’t seem fair at all, does it? I suspect the scales are lying though and you’ll suddenly see it disappear.

The only other thing is this pesky ‘you’re starving me so I’m going to cling on to every bit of fat’ - I know it sounds counterintuitive, but maybe up your calories a little?

Having said that, I’m struggling to lose at all so I probably am not best placed to offer advice!

HeavyHeidi · 31/03/2025 07:38

Must be water, surely you cannot gain 2 kg of actual fat from such calorie deficit. Was the food salty? I can fluctuate a lot if I train harder or eat salty food, but it's just water.

Jins · 31/03/2025 07:46

@MananaMananaPenelope i agree with @HeavyHeidi. I’ve weighed daily for decades and even during my greediest days (all-inclusive in the Caribbean for background) I’ve never managed to gain that much in a week. It’s water or muscle or possibly the most epic of epic poos

I’d contact Oushk personally.

myladyjane · 31/03/2025 08:12

Can I ask a question about loss of effectiveness. This is a general question btw based upon a comment I’ve seen elsewhere.

if you stick to the recommended dosing schedule you reach 15mg in 5 months right? But you get used to doses and they become less effective. So basically the expectation is that you lose the most weight in the first 6 months of starting. I imagine for a lot of people with 2/3 stone to lose that’s ok.

but for those of us who have 4/5 stone to lose (or more), do we expect that it will only get us so far?

I know in reality it’s much more nuanced. I’m only on the start of my third pen, still feeling it working well, only just started 5mg. So in theory it could be 9-10 months for me before I reach 15mg for example or I could never need to.

but for those of us who are slowish losers what’s a realistic expectation do you think? Similar also to the studies that show it supports with losing up to 20% of your body weight. If I lose 20% of my starting weight I’d still obese (just). So still more to go afterwards.

just Monday morning musing I guess. A few of us have said we are in this for the long haul, well over a year if not 2 if not forever but if effectiveness is lost what’s the point?

does it come back to the fact it’s a tool in the box, ie it gets you on the right track and we shouldn’t let it do the hard lifting for us? Or are we setting ourselves up for a fail? One of the things it does for me is turn me off crappy food so I am barely eating anything that isn’t ‘clean’ because I can’t stomach it. But if I stop or the effects wear off, I’ve not taught myself to moderate have I, I’ve relied upon the drug to do that for me.

sorry, probably a bit muddled but be interesting to hear others thoughts.

@MananaMananaPenelope hormones? Headache and bloat weight. I know things are a bit all over the shop there but if something is lurking. I know when I was a daily weighed I’d put on 3/4 lbs a few days over when I ovulated for example.

MananaMananaPenelope · 31/03/2025 08:18

Thanks all, no flipping idea. Hopefully it is water, it won’t be muscle 🤣. The food last night didn’t taste particularly salty, I didn’t eat much at all five or six pieces of chicken plus salad plus a big spoonful of rice, both DCs had some of the chicken I’d ordered.

I’m literally doing the same thing I’ve been doing since January. Still start my day with 500ml of water with electrolytes and drink plenty of water/herbal tea.

Let’s see what this week brings. I think think I’ll go for 3.75mg, I was going to inject this morning but I need my headache to recede a bit first.

I’m on leave today, hopefully I’ll be gardening, dump runs and building a bin store when my painkillers kick in. 🤞I’ll forget how fed up I am with a bit of sunshine!

HeavyHeidi · 31/03/2025 08:25

obviously not a specialist but hoping the GLP works similarly to for example thyroxine. Meaning that I also had to build the dose up, not to go for full whack straight away. But once I got to my correct dose, I can stay there and it works, my body does not get used to it and I don't need to keep increasing.

Not sure waht will happen to my aversion of junk food and alcohol if I come off the shots. But I'm not planning to do that any time soon. Hopefully I've gotten used to the new ways of living by then? Normally during work trips, we always had a few drinks in the evenings and woke up less fresh than ideal - this time I didn't want more than half a glass and have to say, really enjoyed my mornings without any extra tiredness.

Jins · 31/03/2025 08:41

@myladyjane I think the 20% statistic is the expected loss in 12 months so I’d expect weight loss to continue. I don’t think we get used to the drug in the same way that we do with painkillers, it’s more that we move slowly to the dose that works for us. I needed to move up fairly quickly but I’m pretty happy with what I’m on now and will probably stay here for a while.

The way it works mimics what should be our natural response to eating by increasing insulin etc. We’ve all got damaged responses in various ways so theoretically when we find our dose we should be ok for a while. As we lose weight our natural responses tend to improve so we should be able to titrate down.

It’s definitely a ‘trust the process’ drug 😆

DareDevil223 · 31/03/2025 08:53

@myladyjane if it's any reassurance I've lost 9 stone over 2 and a bit years on Ozempic. then Wegovy and now the last bit and then maintenance to MJ and I haven't felt any loss of effectiveness. I am a "super responder" though I think and have never needed to go up to the very high doses.

I had the odd break in treatment when the shortages were going on and some times when I maintained for a bit so I probably could have lost it faster but it's never stopped being effective for me.

Jins · 31/03/2025 09:12

Mini whoosh today and I’ve now lost more than I have left to lose!!!! I’m 51.5% towards goal. BMI 25.2. Sub-cut fat still way higher than it should be but I’ll get there eventually.

Yesterday was fully catered by the DSs for Mothers Day so breakfast (I’d forgotten there was such a meal) was smoked salmon and cream cheese on a gluten free bagel while they had smoked salmon with scrambled eggs from our own chickens. Looked glorious but I can’t eat eggs. It’s a texture thing. DS1 did his signature biryani in the evening. A much carbier day than I would have liked and I had to fight the urge to snack in the evening but I still had a mini whoosh.

Looks like I’m developing a little bit of self control 🤣

DGonMJ · 31/03/2025 09:51

@MananaMananaPenelope v strange, is it just this week that you’re gaining? I’ve definitely had these moments where I’ve increasingly gained over a few days before losing again. Perhaps you’ve hit a set point or perhaps there’s another reason for inflammation and your body clinging onto water to heal a bit - did you do a lot of walking over your golfing days? You could try eating intuitively over the next few days, as others have said sometimes upping calories for a bit and then reducing helps to kick start your metabolism. Or, if you do go up a dose there’s a good chance it could flush the water out. We’re literally our own guinea pigs, just feeling our way through this!

@Whisperingdevil I’ve not topped up between jabs. On days where I feel suppression is low I usually hold out till the next jab and sometimes find suppression increases towards the end of the week. Eating higher fat foods tends to re-ignite suppression for me. Avocado, nuts, smoked salmon, mackerel.

@HeavyHeidi I’ve had that same smug feeling since giving up drinking last summer 😂 if I go to a big after-work drinks session for a leaving do or a birthday, I have a non-alcoholic beer or two. Leave in good time, and wake up fresh as a daisy while everyone else is nursing their hangovers. I’ve had my fair share of those over the years and I do not miss them at all.

@myladyjane interesting musings, and like others I do believe there’s a set dose that works for each individual, but also that it’s best used as a tool within a lifestyle change not a total solution. But this is based on what I’ve read so far, which is research only conducted on diabetics.

The way I’m currently using MJ is for a sense of mild suppression - enough for me to want to eat three meals a day. I rarely have nausea or a physical feeling of fullness putting me off food. However I do now have a light sense of satiety to stop eating, and the ability to think ahead about side effects I want to avoid to prevent me from choosing certain foods. I’m under no illusion that this self-discipline is purely my own, I know that MJ is enabling me to make these decisions. And that actually I’m in a relatively lightly stressful period of my life which is also helping to make ‘willpower’ and sensible decision making easier.

Really hoping period comes today. Had that exhausted feeling yesterday where I was looking forward to retirement. I’m 46! And hoping for at least one more promotion before I retire in 20 years time. I recognise that this is hormonal and my brain going into hibernation mode for a few days.

Had a strange side effect last night (alongside retirement craving) where my stomach felt very full as though I was wearing a corset, and I could feel it slowly contracting in waves and it was causing my mouth to water. When I explained to DH, he thought I might vomit, but I didn’t feel any nausea. I expect either the roast chicken I had was quite fatty or maybe the roasted cauliflower was too crunchy.

Upperroom · 31/03/2025 09:55

Wk11 day1

SW 12st ish
CW 9st 12
GW 9st

its been lovely to carry on reading everyone’s progress last week and today. My son was discharged over the weekend so that’s a relief. I have to say the lack of appetite whilst I was in hospital with him was really useful! I’d have eaten so much rubbish probably otherwise! I am feeling waves of faintness- I’m someone that naturally has low blood pressure. I’ve decided I’m going to stick to 7.5 for my next pen as it’s working so well. I’m feeling very hopeful for summer. Chomping through chocolate every night now seems so alien?!

HeavyHeidi · 31/03/2025 10:00

@DGonMJ ha I'm 46 too and was just thinking about retirement yesterday - but not with anticipation, rather trepidation. What would I even do? I enjoy weekends and holidays as much as the next person, but I do like to have them as breaks. Not sure I would manage to ..rest, if it was a permament state.
Then again my mum is 70 and working full time..

2025istheyeari · 31/03/2025 10:14

MananaMananaPenelope · 31/03/2025 08:18

Thanks all, no flipping idea. Hopefully it is water, it won’t be muscle 🤣. The food last night didn’t taste particularly salty, I didn’t eat much at all five or six pieces of chicken plus salad plus a big spoonful of rice, both DCs had some of the chicken I’d ordered.

I’m literally doing the same thing I’ve been doing since January. Still start my day with 500ml of water with electrolytes and drink plenty of water/herbal tea.

Let’s see what this week brings. I think think I’ll go for 3.75mg, I was going to inject this morning but I need my headache to recede a bit first.

I’m on leave today, hopefully I’ll be gardening, dump runs and building a bin store when my painkillers kick in. 🤞I’ll forget how fed up I am with a bit of sunshine!

I have no words of wisdom other than to say I put a pound on last week and couldn’t understand why (I was v miffed!), it’s come off this week. You simply can’t have put 2kg on in a week so hopefully it will disappear with more over the next couple of days🤞🏻. So annoying though and you’re doing everything right. Otherwise as Jin suggested, maybe contact Oushk? Hope you enjoy your day in the sunshine!

olivietolivie · 31/03/2025 10:27

Upperroom · 31/03/2025 09:55

Wk11 day1

SW 12st ish
CW 9st 12
GW 9st

its been lovely to carry on reading everyone’s progress last week and today. My son was discharged over the weekend so that’s a relief. I have to say the lack of appetite whilst I was in hospital with him was really useful! I’d have eaten so much rubbish probably otherwise! I am feeling waves of faintness- I’m someone that naturally has low blood pressure. I’ve decided I’m going to stick to 7.5 for my next pen as it’s working so well. I’m feeling very hopeful for summer. Chomping through chocolate every night now seems so alien?!

So pleased your son has been discharged.

I really relate to what you said about the thought of eating chocolate every night being so alien now. It really is! I find it strange when someone offers me a packet of biscuits as my answer now is ‘obviously I’m not going to eat those’ - who even am I?! Previously I would have eaten the packet washed down with a bottle or more of wine.

Jins · 31/03/2025 10:34

HeavyHeidi · 31/03/2025 10:00

@DGonMJ ha I'm 46 too and was just thinking about retirement yesterday - but not with anticipation, rather trepidation. What would I even do? I enjoy weekends and holidays as much as the next person, but I do like to have them as breaks. Not sure I would manage to ..rest, if it was a permament state.
Then again my mum is 70 and working full time..

I’m the other side of retirement and I can’t find enough hours in the day to do the things I want to do and have never had time.

Fear not. You won’t be bored

MJalltheway · 31/03/2025 10:47

Fantastic milestone @Jins 🙌

@MananaMananaPenelope you definitely would not have put 2kg of fat on in a week. I saw a great reel on Facebook last week where a personal trainer was talking about exactly this, I'll have to see if I can find it. He was saying it's almost always that you've retained water for some reason - a workout, salty food, hormonal etc etc.

Im on holiday this week (at home) and have been up and to a fitness class first thing this morning 💪

Out of interest, I'm weighing every day this week and so far have dropped every day since weigh in - I've just moved up to 7.5mg so assume that's why! But it means if I keep at this, I've reached both 10kg lost and 10% of my body weight lost!

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