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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

Death linked to Mounjaro

412 replies

suki1964 · 08/11/2024 01:18

https://www.bbc.co.uk/news/articles/cz6jg6nw2zeo

I am in no way knocking anyone who is using these drugs, seriously if I could use them I would. However Im throwing this up here because these drugs have only been tested and deemed safe on a small study - those who's BMI is above 30.

Susan McGowan looks into the camera smiling - she has blonde hair in a short bob, black-rimmed glasses and a light grey t-shirt

Nurse's death linked to weight-loss drug Mounjaro approved on NHS

Susan McGowan from North Lanarkshire died two weeks after taking the drug tirzepatide, brand name Mounjaro.

https://www.bbc.co.uk/news/articles/cz6jg6nw2zeo

OP posts:
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SilenceInside · 08/11/2024 12:31

@Froggerz it's not a bandwagon, it's been my life. I'm nearly 50, I've been obese for nearly the entire majority of my adult life, and was obese as a child. Do you not think that I haven't dieted and exercised in all that time?? Come on. I've done all sorts over the years, and guess what? Yo-yoing up and down, yet always more up than down in the long term. I don't have whatever level of "willpower" that you think is necessary. You can call that a personal or moral failing if it helps. I don't mind. People with that level of persistence and will power will lose weight and not need medical help, great for them and I wouldn't suggest injections to anyone who doesn't want them. But please don't patronise people like me with this head-tilting "it just takes hard work and willpower" kind of comment.

Froggerz · 08/11/2024 12:33

But @CocoDC you have an autoimmune condition. I did say in my post for “healthy unmedicated people”… you have an underlying medical condition that hopefully you have been to YOUR OWN GP about and they discussed injectables fully with you before prescribing.

Brananan · 08/11/2024 12:34

TheGoingGetsEasyAfterItGetsTough · 08/11/2024 09:16

She took 2 low doses of Mounjaro for 2 weeks (assuming the starting dose of 2.5mg every week like every other person) before she died. It's obvious some people don't react well to some meds, hence why meds are started on low dose, monitored for efficacy and possible reaction, and increased as necessary.

Her death has nothing to do with the safety or not of Mounjaro (or private pharmacies or online pharmacies or HCP monitoring unless she didn't buy them from a legal and registered one, which hasn't been mentioned) anymore than someone who took another prescription meds which didn't agree with them died and suddenly there are safety warnings about that drug. Even if she was prescribed this by a physical GP, she'd likely have reacted the same way to the drug in 2 weeks of starting and she'd likely have the same outcome as the HCP or GP wouldn't have been literally monitoring her reaction at home everyday. The issue was her body's reaction to the drug and not the drug being fake or from a private pharmacy.

This isn't about "defensiveness" (🙄) like a pp claimed but questioning and commenting on the usefulness of this news and 'warning' as opposed to other drugs that's done the same. Granted, it's still relatively new in its use in the UK so any news about it will be plastered unlike all the other meds. At some point, the opposite will be the case like other meds.

People who use Mounjaro already know (and others who haven't should read) information about Mounjaro before they take it, like every other medicine. If it didn't work for you, it doesn't mean it's bad. It just means it didn't work for you, like every other meds.

Sad for the woman and her family.

Mounjaro was listed as a contributing factor.

How on earth would you know that it won't affect you in exactly the same way as it did her? She took medical advice.

The defensiveness about this drug is off the scale.

I take HRT so am used to people criticising my health choices, but I don't get triggered when people point out it's linked to breast cancer.

BadForBusiness · 08/11/2024 12:34

Froggerz · 08/11/2024 12:14

But in most cases moving more and eating less does work.

it’s not nice. It’s not fun but to say it doesn’t work is incorrect.

There may be a few cases eg medication where this doesn’t work but in the majority of unmedicated, healthy people… this works.

just because something is hard… it doesn’t mean it doesn’t work

practicing your piano 3 hours a day for 15 years will get you to pass your grade 8. It’s bloody hard work but it works. Or would you prefer to take a tablet that enables you to learn faster and pass it in a year.

it feels like for LOTS of people it is a quick fix that feels easier than the alternative. and let’s not pretend that this isn’t a bunch of size 14 people that want to get down to a 10. In a lot of cases we are not talking about morbidly obese people with diabetes.

People aren't taking these drugs instead of eating less and moving more.

They're taking them in order to facilitate eating less and moving more.

Eating less is massively difficult and the vast majority of obese people find it impossible in the long term. The drugs enable them to overcome that difficulty.

Saying "well they should just be better stronger people and then they wouldn't need a drug to help them" will not fix the obesity crisis.

RaisinforBeing · 08/11/2024 12:34

I actually ordered these injections but changed my mind and got rid of them after I learned there was a link with pancreatitis. My mum had that recently, and with her it was thought to be related to rapid weight loss, but I believe there can also be genetic links with it. She nearly died from the pancreatitis it was very painful and nasty, so I am just trying to lose weight the normal way currently. Very sad for this lady who died she sounded like a wonderful person.

SilenceInside · 08/11/2024 12:35

@Brananan do people do that often? Do they post articles to the HRT support forum about deaths linked to HRT?

MrsSkylerWhite · 08/11/2024 12:36

All drugs have side effects. Unfortunately, this is bound to happen with any drug in a tiny number of people.
Doctors will talk to people about the risks before prescribing. It’s up to the individual to decide whether the level of risk is acceptable to them.

Brananan · 08/11/2024 12:37

BadForBusiness · 08/11/2024 12:34

People aren't taking these drugs instead of eating less and moving more.

They're taking them in order to facilitate eating less and moving more.

Eating less is massively difficult and the vast majority of obese people find it impossible in the long term. The drugs enable them to overcome that difficulty.

Saying "well they should just be better stronger people and then they wouldn't need a drug to help them" will not fix the obesity crisis.

Loads of people are taking them to avoid having to feel hungry when dieting and that includes women who are a size 14 who want to be an 8, using discount codes off here and lying about their starting weight.

Putting your fingers in your ears and pretending that's not happening is just silly.

Anyway this doesn't seem to have been the case here.

TheGoingGetsEasyAfterItGetsTough · 08/11/2024 12:39

Brananan · 08/11/2024 12:34

Mounjaro was listed as a contributing factor.

How on earth would you know that it won't affect you in exactly the same way as it did her? She took medical advice.

The defensiveness about this drug is off the scale.

I take HRT so am used to people criticising my health choices, but I don't get triggered when people point out it's linked to breast cancer.

You read my post and came out with absolute made up shit. Where did I say or imply that it wouldn't affect me as it did her or that MJ wasn't listed as a contributing factor, and who's triggered or being defensive? What I said is sensible, clear and simple enough for those who have the brains to comprehend it.

SnowFrogJelly · 08/11/2024 12:39

After only 2 low dose injections.. this drug should be banned

Brananan · 08/11/2024 12:39

SilenceInside · 08/11/2024 12:35

@Brananan do people do that often? Do they post articles to the HRT support forum about deaths linked to HRT?

Erm - yes! And you get loads of smug posters saying they've sailed through menopause because they are fit/eat the right foods/slim/take some expensive herbal shit etc so they don't need to take a drug

I just roll my eyes.

Brananan · 08/11/2024 12:40

TheGoingGetsEasyAfterItGetsTough · 08/11/2024 12:39

You read my post and came out with absolute made up shit. Where did I say or imply that it wouldn't affect me as it did her or that MJ wasn't listed as a contributing factor, and who's triggered or being defensive? What I said is sensible, clear and simple enough for those who have the brains to comprehend it.

Edited

It certainly seems to make some people aggressive, that's for sure.

Froggerz · 08/11/2024 12:40

Agree that people are ridiculously defensive about this drug.

id like to point out that we don’t know everything about drugs. And might not for many years.

it wasn’t that long ago that drs were saying smoking was good for you. Then we learn more. Same can be said with lots of drugs and chemicals.

what if we discover that people that use it for more than 10 years have increased risk of cancer for example?

yes someone will be along to say but being fat makes you get cancer too…. Like it’s the only other viable alternative. Which it isn’t.

EBearhug · 08/11/2024 12:40

If you read the information leaflet in any drugs - which you should, but many of us don't - they will often list death as a potential side effect. Any drug which could cause anaphylaxis could result in death. There are risks to everything. I have blood tests every year to check my ... liver or kidney function, maybe both... because one of my prescribed drugs could cause problems, although to date hasn't.

There are risks to everything. Some risks we generally ignore, others we worry about more than is reasonable- we are rubbish at assessing risk, usually. Some people will read this story and think, "it made the news because it's rare, I don't really need to worry." Others will think, "I didn't realise this could happen, I'm not prepared to take something that could do this." And there will be some who say, " yes, it's a risk, but I want the results enough that I'm prepared to take that risk." None of these ways if thinking are wrong. You can only reach a decision based on your own ways of thinking, and the authorities will make overall decisions based on statistics and cost. A one-off death is unfortunate, but a pattern of them is quite a different matter.

TheGoingGetsEasyAfterItGetsTough · 08/11/2024 12:41

Brananan · 08/11/2024 12:40

It certainly seems to make some people aggressive, that's for sure.

I agree that HRT makes some people aggressive and daft enough for sure.

gamerchick · 08/11/2024 12:41

I take HRT so am used to people criticising my health choices, but I don't get triggered when people point out it's linked to breast cancer

Isn't there new research on that link? The original research is 30 yr old, apparently here are developments and the risk isn't as great as once thought.

TorroFerney · 08/11/2024 12:44

CocoDC · 08/11/2024 12:30

You don’t get it. I am fat, I exercise everyday (gym twice a day), am careful never to eat more than 1600 cals a day, but due to my autoimmune conditions I never lost wait UNTIL I went on the weight loss jabs.

I don’t get stomach issues, I don’t even feel appetite suppression, I’m eating exactly what I always have but I’m finally losing fat (I get regular body composition scans and know it’s fat).

Just educate me - you say you were eating 1600 calories pre weight loss drug (which I assume was an amount of calories where you were in a calorie deficit and should lose weight) but you didn't. Are you saying that the weight loss drug enables you to eat less than 1600 calories as it makes you feel less hungry/full sooner/switches off food noise which you couldn't have done with willpower as you'd have felt so hungry?

I ask because it sounds like you are saying despite eating little you were not losing because of illness ie challenging the idea that cutting calories works when in fact, from what everyone has said on here, the weight loss drugs prove that not eating as much does work as that is what the weight loss drugs are helping you to do ie you don't feel hungry. But you are saying it's simply the act of taking the drug, you are not eating any less - what is the drug doing then? The stuff i save read seems to support that the key thing it does it supresses appetite but that's not your view? It's really interesting.

SunQueen24 · 08/11/2024 12:45

All good points but it all really goes back to risk vs benefit.

When choosing to take MJ I justified it to myself thinking of the 17+ years I’ve taken some sort of contraceptive and known about all the very real risks but really, had little choice because it was something I needed to control a bodily function - the risk of an unwanted pregnancy was greater to me than the risk of ill health from the drugs.

MJ is the same. That is a personal choice, it’s definitely good to make people aware of the risks, especially as they unfold with this being such a new drug, but it’s not ok to take the decision out of other people’s hands and tell them how to behave. It should be a discussion between a patient and doctor.

amoreoamicizia · 08/11/2024 12:50

Well, people drink and that causes cancer and excess deaths (amongst other things), people drive, people do many things which may expose them to the risk of death. As long as people are definitely made aware of this risk and are fully informed then it's a calculated risk to be taken (or not).

Wantitalltogoaway · 08/11/2024 12:52

JurassicPark4Eva · 08/11/2024 10:25

The death doesn't worry me. I was awaiting a tonsillectomy around 20 years ago, and my surgery was one of those cancelled nationally after multiple deaths on the table from uncontrolled bleeding. They rejigged the technique and restarted the ops.

Unfortunately life has risks, and for me the risk of staying grossly obese is higher than the risk from Mounjaro.

But being morbidly obese isn’t like cancer or Parkinson’s which require certain drugs to control or cure them, some of which have risks or side effects.

Obesity isn’t a disease. It’s a lifestyle choice. There’s another way of treating it that - shock horror - doesn’t include drugs at all.

SunQueen24 · 08/11/2024 12:52

amoreoamicizia · 08/11/2024 12:50

Well, people drink and that causes cancer and excess deaths (amongst other things), people drive, people do many things which may expose them to the risk of death. As long as people are definitely made aware of this risk and are fully informed then it's a calculated risk to be taken (or not).

Not to mention obesity AND UPF food has a strong link to cancer.

SunQueen24 · 08/11/2024 12:52

Wantitalltogoaway · 08/11/2024 12:52

But being morbidly obese isn’t like cancer or Parkinson’s which require certain drugs to control or cure them, some of which have risks or side effects.

Obesity isn’t a disease. It’s a lifestyle choice. There’s another way of treating it that - shock horror - doesn’t include drugs at all.

Obesity has LONG been recognised as a disease.

TorroFerney · 08/11/2024 12:53

TheGoingGetsEasyAfterItGetsTough · 08/11/2024 12:41

I agree that HRT makes some people aggressive and daft enough for sure.

Edited

Do you think so? I started taking HRT to make me less aggressive as I was wanting to do harm to myself. It has worked hurrah.

We are all defensive about our choices aren't we, it's human nature. Like we get irritated when people spend a fortune on handbags as we dont but ignore how much we spend on our "thing" so cars , watches etc. We also all justify our choices.

Weight stuff does seem to bring out the emotions though.

Wantitalltogoaway · 08/11/2024 12:53

SunQueen24 · 08/11/2024 12:45

All good points but it all really goes back to risk vs benefit.

When choosing to take MJ I justified it to myself thinking of the 17+ years I’ve taken some sort of contraceptive and known about all the very real risks but really, had little choice because it was something I needed to control a bodily function - the risk of an unwanted pregnancy was greater to me than the risk of ill health from the drugs.

MJ is the same. That is a personal choice, it’s definitely good to make people aware of the risks, especially as they unfold with this being such a new drug, but it’s not ok to take the decision out of other people’s hands and tell them how to behave. It should be a discussion between a patient and doctor.

Are you saying obesity is a bodily function, like reproduction?

🫤

Froggerz · 08/11/2024 12:54

@amoreoamicizia

ridiculous.

for starters, I don’t drink because it’s bad for you. Lots of people are coming round to sober life now.

“People drive”…is there an alternative that is completely risk free? Have you heard of an accident free vehicle?

exercise and calorie restriction are safe options for MOST people.

what the drug does is just weird. To your gut, to your blood work, to your pancreas, to your brain.