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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

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35
lurkylurk · 05/04/2024 01:18

ObsidianTree · 04/04/2024 21:09

Perfect! I'll include this link. Thanks

@ObsidianTree
I'd be a little concerned about the length of the needles you linked to, if they are too long there can be a risk of doing an intramuscular rather than subcutaneous injection (into the muscle rather than into the fat). Mounjaro is a subcutaneous injection (into fat) and the needles you've linked to are 13mm long. The ones that come with the pens are generally 4-5mm long.

This article talks about how the ones recommended are usually 8mm long and even they may be too long for comfort and avoiding injecting into muscle instead of fat: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525656/

Subcutaneous Injection Depth Does Not Affect the Pharmacokinetics or Glucodynamics of Insulin Lispro in Normal Weight or Healthy Obese Subjects

An 8-mm needle length is commonly used for insulin injections; however, recent recommendations suggest shorter needles may help patients avoid intramuscular injections and reduce pain, while maintaining adequate glucose control. The goal of these analy...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525656

oaode · 05/04/2024 01:27

ObsidianTree · 04/04/2024 20:15

Hmm! My numbers and formatting has disappeared! Will sort than when we are up to thread 4!

@ObsidianTree You are simply the best and a star. Thankyou for curating this thread and keeping us gals encouraged and motivated!

lurkylurk · 05/04/2024 01:32

@ObsidianTree
Just to add, as my last post came across as a bit critical, thank you for starting this thread and wanting to post tips for new people!

MelissaLouRocks · 05/04/2024 01:42

lurkylurk · 05/04/2024 01:18

@ObsidianTree
I'd be a little concerned about the length of the needles you linked to, if they are too long there can be a risk of doing an intramuscular rather than subcutaneous injection (into the muscle rather than into the fat). Mounjaro is a subcutaneous injection (into fat) and the needles you've linked to are 13mm long. The ones that come with the pens are generally 4-5mm long.

This article talks about how the ones recommended are usually 8mm long and even they may be too long for comfort and avoiding injecting into muscle instead of fat: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525656/

I was the one who recommended those needles to Obsidian, as many were ordering any old crap from Amazon! I know these to be genuine as I have to use the company for other medical items, and my daughter uses these if she has any issues with her insulin pen.

It's often quite difficult to find 1ml syringes with short needles, and these are the shortest I found.

I've said before, if you're going to use needles other than those with the pen, please familiarise yourself with subcutaneous injection, and inject at a 45° angle rather than perpendicular to the skin. It's very important the drug goes into the subcutaneous layer rather than the muscle, as otherwise it will be processed far too quickly by the body.

This will lead to the drug effects not lasting long enough, and may also precipitate unwanted side effects.

I hope I've made that clear.

MelissaLouRocks · 05/04/2024 01:47

One more thing to add to the list @ObsidianTree is for people to take a picture of the prescription label before disposing of their pen box.

As we know, many prescribers are asking for a copy of this if you've moved over from another provider.

It's also useful to keep any approval or dispatch emails.

ObsidianTree · 05/04/2024 07:10

@lurkylurk I'm going to leave out info about the extra dose and needles. As we aren't meant to be using the extra dose, so feel I shouldn't be promoting using it and how. But people can read on the threads about it as we've discussed it a lot anyway.

OP posts:
MoreThanJustANumber · 05/04/2024 07:11

I asked Bolt about when they'd get the 7.5mg in and this is their reply...

Continuing Mounjaro...part 3
ObsidianTree · 05/04/2024 07:26

Flapearedknave · 05/04/2024 00:04

Has anybody been on ozempic previously, been a super responder (literally within an hour) and the found that after a break these medications don't work anymore? I lost 25lb in 4 months on Oz.

I couldn't get Oz last year, so had a 6 month break and wegovy didn't work after. But only titrated to .5.

I'm about to start week 2 on mounjaro and I've not had any effects at all.

Anyone had similar?

I think there are people that have switched from ozempic. I think I remember one person saying it worked for them. But generally what I've seen from people trying to switch from wegovy/ozempic is that it's not worked. I think you might need a higher dose to get more of an effect. So maybe just keep going and see what happens?

OP posts:
NextPrimeMinister · 05/04/2024 07:39

6 week check in. Or is it 7? Can't keep up.

SW 13.12
TW 12.07

1lb off last week, taking me to 19lbs overall.

Was feeling smug until I saw the ideal weight table that says at my height I should be 8 stone. Ha ha.

I'll be happy to get to 10 stone to be honest, which would take me to my pre wedding / 20 years ago weight.

At 8 stone I would be a size 8 which is completely unmanageable for me to maintain.

JanetSnakeholeMacklin · 05/04/2024 07:47

ObsidianTree · 05/04/2024 07:10

@lurkylurk I'm going to leave out info about the extra dose and needles. As we aren't meant to be using the extra dose, so feel I shouldn't be promoting using it and how. But people can read on the threads about it as we've discussed it a lot anyway.

That's probably the right call. Thanks again for the spiel for the starts of threads! Should help a lot of people.

RunningAndSinging · 05/04/2024 07:55

JanetSnakeholeMacklin · 05/04/2024 07:47

That's probably the right call. Thanks again for the spiel for the starts of threads! Should help a lot of people.

Yes I agree. And thank you @ObsidianTree it’s a great idea to do the FAQs.

definitely cover - it’s been 24 hours and I have had no effects on 2.5mg as well as the super responders - it could go either way. A range of good value and reliable suppliers, common side effects and remedies, recommended daily protein, water and veg intake, strength training, injection sites and absorption rates. I probably haven’t suggested anything new here but just agreeing that these are asked a lot.

ooh - I have just thought something about the way the drug builds up in the system over time due to the half life - there was a great graph on that somewhere. Also something about maintaining after coming off the drug - although we don’t yet have this experience. The research isn’t very encouraging about that.

Thebaldprimadonna · 05/04/2024 07:56

NextPrimeMinister · 05/04/2024 07:39

6 week check in. Or is it 7? Can't keep up.

SW 13.12
TW 12.07

1lb off last week, taking me to 19lbs overall.

Was feeling smug until I saw the ideal weight table that says at my height I should be 8 stone. Ha ha.

I'll be happy to get to 10 stone to be honest, which would take me to my pre wedding / 20 years ago weight.

At 8 stone I would be a size 8 which is completely unmanageable for me to maintain.

Great news! I am pretty much spot on the same after six weeks. Feeling so much better for it. How about you?

ineedmoresleepnow · 05/04/2024 08:01

Great post ObsidianTree, it's so helpful reading everyone's advice and experiences.
First week weigh in for me this morning and I have lost 6 pounds. Over the moon with that as I have been losing and gaining the same two pounds for the last three months on my own.

NextPrimeMinister · 05/04/2024 08:15

Thebaldprimadonna · 05/04/2024 07:56

Great news! I am pretty much spot on the same after six weeks. Feeling so much better for it. How about you?

I can see the change now, and clothes look looser. I think I can't quite believe it's happening and am waiting for it to stop/fail like any of my other weight loss attempts have!

RunningAndSinging · 05/04/2024 08:16

Maybe a research article like This one would be good.

A lot of people worry that they won’t get any more of the drug when they reach healthy BMI but if you look at the graph in the research article the weight loss plateaus at between 16 and 22.5 %. If I lost 20% of my starting weight my BMI would still be in the overweight category unfortunately so I am not too worried about losing too much weight as I think that is unlikely.

ObsidianTree · 05/04/2024 08:21

Ok second draft!

Pointers for newbies:

One - When taking your first dose you need to twist the pen a lot to get to 1!

Two - Your first dose may not have an immediate effect. For some people the effects build slowly. It could take 3 or 4 days to notice anything, it could take a few weeks. Some people don't feel the meds working until they get to 5mg. See titration chart which shows how the medication builds up in your system.

Three- 2.5mg isn't a therapeutic dose, meaning you aren’t meant to lose on 2.5mg. You need to start on 2.5mg to get your body used to the drug and gradually introduce it into your system and get used to any side effects.

Four- Not everyone loses a lot in the first few weeks. Don't feel discouraged if you don't lose a lot initially. Again, you might need a higher dose to start losing. Also, inches can be lost without anything showing on the scales. Start your journey by taking measurements and check them as you go along.

Five - If you do lose a lot in the first few weeks, please don't assume you will continue losing at this rate. The first few weeks it is usually water weight that is lost, after than a good weight loss is about 2lbs a week. Some weeks you might not lose anything, but this is ok too…again, taking measurements might show inches lost instead.

Six - Constipation, coldness, nausea, diarrhea, headaches, aches, are side effects. There may be be other side effects also. Read info here :

https://www.medicines.org.uk/emc/files/pil.14201.pdf

Seven - Once you take your first dose you can choose to keep your pen in the fridge or somewhere else. It's up to you.

Eight - Don't reuse any needles as this could risk infection. If you damage a needle or one isn't working, you can buy a pack of about 100 spares. Ask for suggestions of sites /types to buy.

Nine - Protein is important as eating less protein can cause muscle wastage and hair loss. Try to have at least 100g a day. There are protein supplements you can take. Myprotein have a good range. Ask for a referral code if you want to buy some.

Some natural sources of protein:
https://www.bbcgoodfood.com/howto/guide/best-sources-protein

https://www.medicalnewstoday.com/articles/321522#high-protein-foods

Ten - You can use supplements, some that people use are magnesium(for sleep and constipation), protein(to reduce muscle wastage), collagen (skin elasticity), aloe vera(for constipation), electrolytes.

Eleven - Drink lota of water. Water helps with the weight loss. Drink at least 2ltrs a day. Preferably 3ltrs.

Twelve- Don't be afraid to feel hungry. It is entirely normal and healthy to feel hungry. Just eat something. Treat it as an opportunity to start good habits around hunger. Eat a nice balanced snack or a meal if it's a meal time. It's ok.

Thirteen - Some of the places you can order from are:

  • MedExpress £149.99 - Sometimes there are codes that can be used for a discount. Ask for a code on here or do a Google search to try and find one.
  • Voy - £114.99 for first month then £229 after. Need a referral code (ask on here for one if needed)
  • The Family Chemist -£149
  • Simple online pharmacy - £159 2.5mg £179 for 5mg
  • Asda £184
  • Boots £219
  1. Does it makes any difference where you inject? yes it does! Drugs get absorbed at different rates depending on injection site

In order of fastest absorption, it goes:
• Tummy
• Arms
• Thighs
• Bottom
further reading about injection sites and the effects: https://www.medicalnewstoday.com/articles/316618

  1. You can track your calories / protein on apps such as My fitnessPal, Carb Manager or Nutracheck. Nutracheck is quite useful and easy to find foods /build recipes.

  2. If you want to switch suppliers, make sure you have pics of your Mounjaro box with your name and dose. This will come in useful when other suppliers ask for evidence.

Continuing Mounjaro...part 3
Continuing Mounjaro...part 3
OP posts:
ObsidianTree · 05/04/2024 08:28

It kept changing the numbers to 1! Have edited but it's still a mess!

OP posts:
lurkylurk · 05/04/2024 08:29

NextPrimeMinister · 05/04/2024 07:39

6 week check in. Or is it 7? Can't keep up.

SW 13.12
TW 12.07

1lb off last week, taking me to 19lbs overall.

Was feeling smug until I saw the ideal weight table that says at my height I should be 8 stone. Ha ha.

I'll be happy to get to 10 stone to be honest, which would take me to my pre wedding / 20 years ago weight.

At 8 stone I would be a size 8 which is completely unmanageable for me to maintain.

@NextPrimeMinister

Sorry about putting that table here! I know what you mean, I've only been the weight it says as ideal for my height once in my adult life and it was unsustainable, settled at half a stone to a stone heavier which was still a healthy BMI.

I was only posting it as maybe someone could use it to get prescribers to allow them to go past a 25 BMI (as it is an NHS chart) as stopping right on the line would mean a large meal makes you overweight as someone else put it!

MelissaLouRocks · 05/04/2024 08:33

ObsidianTree · 05/04/2024 08:28

It kept changing the numbers to 1! Have edited but it's still a mess!

But all the info is great, I can't think of anything you've left out off the top of my head. 💐

Stickthatupyourdojo · 05/04/2024 08:46

It's fab @ObsidianTree, thank you.

Well done on your losses @ineedmoresleepnow and @NextPrimeMinister 🥳

JanetSnakeholeMacklin · 05/04/2024 08:51

Post looks great @ObsidianTree !!

Rainbowl · 05/04/2024 08:52

The list is fab thank you so much @ObsidianTree

As a newbie this video was so helpful. Do you think it’s worth including a link? That’s the only other thing I could think of.

How to use the Mounjaro Injection Pen: Step-by-step guide

Welcome to the PrivateDoc Guide on how to use a Mounjaro Kwik Pen.To find out more visit: http://tinyurl.com/2cjtv4enhttps://www.privatedoc.com/

https://youtu.be/4SgQUlM6MrQ?feature=shared

sassygirlx · 05/04/2024 08:54

Flapearedknave · 05/04/2024 00:04

Has anybody been on ozempic previously, been a super responder (literally within an hour) and the found that after a break these medications don't work anymore? I lost 25lb in 4 months on Oz.

I couldn't get Oz last year, so had a 6 month break and wegovy didn't work after. But only titrated to .5.

I'm about to start week 2 on mounjaro and I've not had any effects at all.

Anyone had similar?

I could have written this!
First shot of Ozempic and later that day my appetite just disappeared....and this lasted for the entire time I was on Ozempic. The side effects however were utterly horrendous. Constant D&V 😳
I lost three stone and then couldn't get any more due to only being available for people with diabetes.

Had a four month gap and went onto Wegovy.
No effect whatsoever....and I went up to 1mg.
I actually did wonder if I was injecting myself with water, but for the side effects!

One and a half stone back on.

Now on Mounjaro. No side effects at all but also no change with my appetite.
Due to start 5mg in one and a half weeks but will try a 5mg shot next week (2.5mg shot plus the leftover solution in the syringe)

Fingers crossed!

ObsidianTree · 05/04/2024 08:55

Rainbowl · 05/04/2024 08:52

The list is fab thank you so much @ObsidianTree

As a newbie this video was so helpful. Do you think it’s worth including a link? That’s the only other thing I could think of.

I'll add this video too. Thanks :)

OP posts:
Soukmyfalafel · 05/04/2024 08:59

NextPrimeMinister · 05/04/2024 07:39

6 week check in. Or is it 7? Can't keep up.

SW 13.12
TW 12.07

1lb off last week, taking me to 19lbs overall.

Was feeling smug until I saw the ideal weight table that says at my height I should be 8 stone. Ha ha.

I'll be happy to get to 10 stone to be honest, which would take me to my pre wedding / 20 years ago weight.

At 8 stone I would be a size 8 which is completely unmanageable for me to maintain.

When I tapped my details into some apps they said I should be 8st 4lbs. I have been that weight in my 20s and I was TINY. A size six. I even got asked if i had an eating disorder by a few people (I didnt, but i walked everywhere and had an active job which meant i walked miles everyday, so struggled to gain weight despite my huge appetite). I don't think that would look good on a forty something. I would be happy at 9st (I'm short and quite small framed underneath the flab, but do have a bit of muscle too).

I think some of these apps encourage more weight loss for their own benefit to keep people using them longer.

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