So she escapes the spacesuit, after calling the president, and regenerates in an alley, with the homeless man.
Except...if the spacesuit was full of lifesupport, how did she survive outside of it?
Also, when we see her at the orphanage, she's white. So...did she escape the creepy stuck in the past orphanage while in the spacesuit? Then how are there pictures of her as a baby with Amy? Or even pictures of Amy?
Then she becomes Mel and is inserted into A&R's lives. Who were her parents? Who did she live with? Was she ever really there or was it just the memories of her inserted into their heads, a la Dawn on Buffy?
Then Mel regenerates into River and she's suddenly a killing machine. How did that happen? Who actually taught her to be one if she grew up with A&R?
Of course all of this can be explained with timey whimey space travel cop out stuff.
Finally, at what point was Amy replaced with a Ganga? Was it ever Amy until they are on the space station and we find out she's had a baby?