I have Chanel, Balenciaga, Fendi, Dior, Mulberry, etc. and am set to “inherit” a vintage Kelly (my mum’s, a present from his godfather in the 50s, when it was not that expensive/exclusive); I use them all the time but they are very “usable” (11.12, Boy, Lariat/City, Graffiti, Baguette, Saddle, etc.) and I’m in London, where you see people with this bags all the time. Anyway, my most used bags for work are the Mulberry Bayswaters although I use the Graffiti and Saddle all the time. Also the Boy, although it is more delicate and you need to be careful. Must of them are ‘bonus’ presents from my husband (chosen from my wish list).
There are, however, bags I would never buy (like Goyard, Hermès or Louis Vuitton) for different reasons, and I will only save for an ‘investment’ bag.
I agree that most second hand bags are very well cared for but would not buy from eBay or a Facebook group. I would only trust something like Vestiaire Collective or a very reputable authentication company.