If you've had a couple of dates with someone and they stop responsing and you see them on pof again, then no, they don't come back.
It could be something you did, or said, or it could simply be that they reacted to the fact you cough like their ex, or drink the same beer as their father, or like the same band as them. Or no reason.
It's very difficult to do, but you have to just accept that people are weird and you can't control how people respond, and move on. Sometimes there isn't an explanation, as difficult as that is to accept.
Almost all new relationships fail. They're like those little baby turtles you see on a David Attenborough documentary, crawling toward the sea, with the sad narration saying that two out of every hundred will actually make it to adulthood, and the rest will be eaten by seagulls, or by fish, or be ghosted, or breadcrumbed.
Dating is hard. When it works out it's fantastic, but when you realise that this person isn't right, or -even worse - they realise it - that's tough.