Anyone taking part in the Response Medical Trial or any other medical trial?

[sizethree]

Hi, I'm taking part in the Response medical trial and wondering if anyone else on here is too?
It's been a very difficult year and a half and I have had three consecutive miscarriages, 1st in Nov 2013 at 12 weeks, 2nd in July 2014 at 7 weeks, 3rd in Nov 2014 at 9 weeks. It's a 4 month waiting list for my Recurrent Miscarriage Clinic so I'm taking part in the trial as want to keep things moving as worried I'm running out of time (I'm 36 this year - although I was 33 when first started TTC) but I'm in the 2WW and feeling terrified.
There's a lot of extra support offered as part of the trial but I'm feeling a bit lonely and out on a limb about it.
Anyone else on the same boat or had medical trial experience?

You're not far off the 6 weeks even if they are counting it from ovulation. So confusing that they do a diff week count than usual. Keeps us on our toes!
I didn't realise they were weekly appointments. I thought I was told up here that it's every foethnicity.
We weeee planning 2 weeks in the Caribbean, but now looking at just a week in May (over 2 year wedding anniversary) to the Canaries or somewhere else warm that's not long haul flying.
I'm wishing you the speediest and anxiety freest of weeks ahead. Every hour seems like an age at this stage of pregnancy. I know that time slowing down feeling too well.
But glad you are excited. It must be comforting knowing you have a team cheering you on and that extra support of scan etc.
Happy Valentine's day. What a great present!

Hi snoopy.
So sorry you find yourself here.
Miscarriage really is such an awful heartbreaking experience.
Have you had it confirmed? Or are you in that awful waiting period inbetween scans?
Thank you for your helpful information about the injections. That's really handy to know.
Please let us know how you're getting on. Even between choccy and I we have a wealth of MC knowledge to tap into and handholding whenever needed.

I'm only just over five weeks so I figure there's no point in scans. I'm just waiting to get second hcg bloods done.

This will be my second mc in three months. The only solace is I seem to be able to get pregnant first cycle, is that a good thing?

I was on cyclogest from bfp for this one which is why I was watching your trial.

Congrats choccy!

Snoopy so sorry sweetheart. Mc is an awful thing to go through at any stage.
What is happening with you now to think you've started again? Have you contacted the epu lively to you? Ours is closed over the weekend, but if your tests are still showing + on Monday, ask if you can go in and be scanned. I've been in at 4+5 after a bleed and they found a sac and yolk. I was going on holiday the next day for a month so they wanted to scan me and on hol 2 weeks later. I did obviously lose it, but I saw it at least and it may have carried on, no one was to know at the time.

Great to know about the injections. I did wonder how people with insulin etc took them away. Thank for that.

With regards getting pg, it is good that you know you CAN get pg. Prob with me is I catch every cycle we've tried. I lost 3, had a month off, 3 more (those on Cyclogest from 7dpo), 2 months off, lost 2 more (both on cyclogest, the last one beingy longest and took cyclo from bfp). We didn't try for 2 months nov and dec and Jan I didn't catch!! Tmi I know but we had a LOT of sex (2-3 times a day for about a week) and I actually think it worked against us.

Who put you on cyclogest?
I'm on nothing now bar pregnacare and now injections.
I was taking all sorts like epo to ov and omega 3 after ov, b6, b complex with vit c, vitamin d3, coq10, I think that's it!
But due to the trial I've been only allowed to take normal conception pills. Watch this space......

How are you sizethree, happy shagging

Oooo re appts, they are weekly from BFP to 6 week scan, then scan/appts fortnightly at 8, 10 and 12 weeks :)

I'm bleeding quite a bit. I'm going to take the cyclogest until I get the results from the hcg tests.

I have hypothyroidism, vit d3 deficiency and a family history of autoimmune disorders so after the first mc, which was a mmc, I went private to check thyroid antibodies. The Dr was good and said my thyroid was being well managed. He left it up to me whether I had further tests and I didn't at that stage. He prescribed cyclogest as he said it wouldn't hurt and adviser baby aspirin was fine to take as well.

Oh god choccy, no one should have to deal with so much loss, you're very brave.
We tend to dtd once a day whether fertile or not.
I'm 29 now and I'm aware that if I'm going to need intervention the earlier I get it the more chance of success there is. I am worried about family history.

So sorry snoopy :( but just keep hoping. A friend was carrying twins (she didn't know) when she started bleeding and other was there, so there is hope something may still be there.
Wise to stay on the cyclogest until you know the outcome.
It's good to know there is testing for you if needs be, and with you still being young, you've bags of time.

I'm 35, but DH is 41 in May and we always said we'd stop trying then as he didn't want to be too old. I just feel I'm on countdown now, but there did have to be a limit.
We have a beautiful ds, so if things don't work out, we are lucky to have him at least :)

Hello. Mission baby making accomplished this weekend, so now in the dull 2ww.
Off to the rugby at Murraufiekd this avo which will take my mind off it for a few hours.
How are you holding up Choccy? That's you three injections in isn't it? You getting into the routine?
Snoopy how are you doing?
Do you have to wait till tomorrow for follow up HCG test?
Secind miscarriage in 3 months is brutal. I had 2 within 4 months and it knocked me sideways. Physically but also emotionally.
It is positive that you conceive easily, although I know this feels like no consolation.
I'm only on cycle two of trying again this time for the trial. And so hoping that I'm not still seeing BFN's in 6 months as it took me 7 months to fall pregnant the secind time.
It's just all so ridiculously unfair.
The first miscarriage snatchs the whole joy of pregnancy experience away and you can never get that back. But it does teach you resilience and determination and you meet some other wonderful women along the way.
Let me know how you are both getting in today.

All good thanks sizethree! Yes 3 injections in. This mornings pinched a bit but I thinkni did it at the wrong angle!

So you've had a fun weekend then diners tightly crossed for you this month!!

Oooo Rugger sounds fun. We're at bil and sil at the moment watching the Scotland Wales game.
Came over for dinner with mil and fil and we just told them. Said it's early days but said about the trial etc.
It's awful because you just can't get really excited. Wasn't going to tell them but my parents know as they picked up DS from preschool Tuesday when I went to hospital and they sent me home. So thought it only fair they know too.

All good otherwise, just feel extremely tired all the time. Been falling asleep at 8.30/9pm last couple of nights and just feel tired all day.

How you doing snoopy?

The bleeding is lighter. My cervix is closed. I haven't really had any pain (had more twinges in the early stages of mmc) I don't really know what to do. Obviously the gp surgery is closed.

Choccy I hear you about PIL. DH told his mum when we got a positive and now had to update her with this. I don't get any contact unless I'm pregnant and clearly I'm just a failure once again so she hasn't contacted me this time. I'm such a useless daughter in law aren't I.

Snoopy please don't think that. This is NOT YOUR FAULT!! Please contact your local epu tomorrow. Phone your local hospital and ask fir the early pregnancy unit and book yourself in!
Re your mil, if she's thinking it's your fault, she's not really a very nice person is she!

How's things today snoopy, did you ring EPU? Xx

Second one confirmed this morning.

My TSH levels are up from 1.27 to 2.28.

I'm done. I've got nothing left. Thank you for all your help and support. I wish you the very best for the future.

Snoopy, I'm so very very very sorry. If you need to offload, scream, shout or anything, please feel free to pm me sweetheart. Big hugs to you and happiness for the future xxxx

I had my second appt today, alls well. Much quicker at this one as my injections were already waiting for me, had my bloods and that was that!
Booked in for next Tuesday same time. Scan is following weds. Please let this be it!

Hi ladies hope you don't mind me joining this thread. I suffered my 3rd miscarriage in 7 month in jan and today I have signed up to take part in this trial. Feeling a little unsure with not fully knowing risks etc but as you ladies know I would do anything for a healthy baby. so sorry for your losses it truly is such an awful thing to go through.
Congratulations choccywoccydodah such wonderful news for you.
Lots of love and luck to you all xx

Hi Claire and welcome. So sorry you find yourself here, but lovely to have your company on this roller coaster of a journey.
That's a hell of a tough 7 months you've just been through. Well done for coming out the other side and braving it again.
I'm currently in my 2WW and in cycle 2 of the trial. I'm already getting impatient. It took me 7 months to fall pregnant again after my first MC so hoping that it's no going to drag out too long.
How are you feeling about the trial?
The big wad of paperwork explains the risks but my understanding is that this is phase two of the trial (so big probs would've been ironed out) and that the test group previously included more vulnerable patients on chemo etc. So being fit baby makers we should be grand!
When do you start ovulation testing? We are all at different stages so that's quite exciting!

Choccy so glad it went well are more smoothly than last week.
Hoping for a fast week ahead as I know how much time drags on the early days.
Is your scan a week tomorrow or two weeks tomorrow? Got s bit confused by the followings weds.
How are you with ultrasounds? I have them with a passion. I sing know if I can ever bring myself to look at the screen again. Too much sad news delivered that way unfortunately.
So sad about Snoopy. Not sure if you'll dip back in Snoopy but I really am so sorry for your loss. It's just so brutal the secind time around. Take time to look after yourself and heal and I hope in the future you'll be able to hold your baby. Big hugs.

I'm feeling okay about trial but aprehensive also suppose that's just normal. Only thing I would say is I feel like I 'll be constantly doing either ovulation or pregnancy tests!! I use opks anyway now have to use them a lot earlier and for a lot longer than I usually would same with p test I would always wait as long as possible to test but I will have to test a lot sooner , Which is a good thing as far as trial concerned but just means I would know sooner therefore have longer to worry if that makes sense!! Do you have any children sizethree? I have read the whole post but can't remember!! I already have a gorgeous son who has just turned two it took 10 mth to conceive with him although since we started trying this time Which was last April I have fallen pregnant relatively quickly but haven't got past 7.5 weeks. It's so upsetting and emotionally really takes its toll as you know. As far as where I am in my cycle I have no real idea I had a scan early Jan which confirmed I had miscarried in Dec but then went on to have a more bleeding on and off I have now gone 31 days and started with browny discharge on Sat Which I presumed was star t of normal period but it's just stayed brown since hoping this is normal? I had positive opk on. Day 18 & 19 so think I have ovulated . Anxious to get back on track so I can start properly trying again. What day are you on?xxx

Morning ladies!
Welcome Claire, sorry you're here and so sorry about your recurrent losses, truly awful awful! just as you start to get excited, your world comes crashing down :(

You sound exactly how I was, really apprehensive, but I felt so much better at the appt to sign up for the trial. So much gumph to read through, but it does make sense what it all means and what they are trying to do.

My scan is 2 weeks today sizethree, so it will be my 5 week appt next tues, then scan following week the day after 6 week appt is due. They scan on a weds and fri here, but your appts have to be within 1 day either side of the weekly appt (ie mine was a tues, so my appts have to be on a mon,tues or weds).

I've no children yet. Which makes me even more nervous as I don't know if my body is capable of a full term pregnancy.
I'm on day 20 so start testing tomorrow morning. It does seem very early and yes, you do find yourself peeing on sticks most of the month, but it's comfirting to know you're going everything possible.
I've definitely covered all bases this moth (I did last month too) so hopefully of a BFP.
I get endometriosis as well which makes things pretty sore at times and I have pain today which could be either endo or implantation.

Forgot to say re scan, I don't mind them. I think it keeps me going the thought of something actually being there. Obviously totally and utterly devastated when it turns out it's gone, but the thought just keeps me going.
I'm just so paranoid at the moment. Wearing white knickers every day so can look out for spotting (ott I know). I'm just so petrified of it happening again.
I feel ok in myself, just tired and can feel the stretching going on, but I won't get really excited until I get to the scan (hopefully)

Oh sizethree I really hope this month is your month I've my fingers crossed for you. It must be exciting knowing you are about to test.
It makes me feel better knowing I 'll get an earlier scan as its such a worrying time I know it can't prevent anything happening but just knowing I haven't got to fight to get an early one is good. I can imagine how your feeling choccywoccydodah and wearing white Knicks is exactly what I would do. I really hope all works out for you xx

I wore a panty liner every day of my last two pregnancies as was so paranoid. And will do the same for my next for peace of mind. Going to the loo is so nerve wracking!
But the extra support and scans you get in the trial should help with the anxiety. At least in hoping so!

Any luck sizethree?
God I hope it's your month!!!!

All good here, still free of spotting. One week til I'm past my danger zone, 3 days til I'm out of the starting spotting zone.
Feeling ok. Lots of belly stretching etc going on, feels heavy there too, my back started hurting yesterday at the bottom and my nipples twinge on and off. Had to take my bra off last night as my boob area felt tight, although I don't think they look any bigger.
Been going through my pregnancy diary with ds, and had the same with him. I had no sickness or many symptoms with him, but I did start to feel sick around week 5.
Here's hoping.......:)