This, from the BMJ, even shows considerable increased gestational diabetes risk due potentially to aging of fathers sperm...
... data on all 40,529,905 live births that took place in the US between 2007 and 2016 to look at the impact of paternal age on a range of outcomes for the infant and the mother.
They found that as the age of the father increased so did the risk of the infant being born prematurely, having a low birth weight, and requiring healthcare support after delivery, such as assisted ventilation, admission to neonatal intensive care, or antibiotics.
After adjusting for age of the mother, maternal smoking, race, education, and number of prenatal visits, children of fathers aged 45 years or more were born 0.12 weeks earlier and with a 14% higher odds of being premature (less than 37 weeks) compared to those whose fathers were aged 25 to 34 years.
Children of fathers aged 45 years or more were born 20.2g lighter and had a 14% greater risk of low birth weight (less than 2500g) than infants born to younger fathers.
Infants with fathers aged 45 years or more also had a 14% higher odds of being admitted to a neonatal intensive care unit and a 18% higher odds of having seizures, compared with infants with fathers aged 25 to 34 years.
If the father was aged 55 years or older, newborns also tended to score less well on the Apgar test–a test used to quickly assess the health of a child at birth.
The risk of gestational diabetes for pregnant women also increased in line with the age of the father, with women carrying the child of a man aged 55 years or older having a 34% higher odds of gestational diabetes.
The researchers estimate that around 13% of premature births and 18% of gestational diabetes in pregnancies associated with older fathers were attributable to the advanced age of the father, and suggest that changes in the sperm of older men might explain their findings ....[continues]