It's a shame for those like in Mrbo's sil example, but I think there are a lot of us who fortunately are in less extreme positions.
My experience having 2 at school and 2 at nursery at the moment, is that school is a lot easier to manage - first of all they don't get ill as often, second they don't mind being left occasionally at childminders/after school clubs, in fact a lot of them love to go as most of their friends attend these sorts of places. Also, and most importantly, the guilt one carries of leaving babies/young tots is not there anymore as they would be at school anyway whilst one is at work, and that to me makes a huge difference.
School plays, school activities where parents are required are maybe 5 days a year including school plays (x2), parent's evening and a couple of assemblies. Often it is possible for us at least to just leave work early and make up the time the next day. We haven't found it a problem so far, and we are 3 years in, our DD1 being in Y2.
All this without the cost, which does get a lot cheaper, even with the holidays. There are a lot of solution for school holidays which do not have to cost and arm and a leg - where we are at least.
Of course travelling all over the world does not suit, but frankly I don't think it suits anyone with a young family, man or woman, generally speaking. I know that my DH would hate to be in a job like that even without a family - it's not much fun living out of a hotel constantly, the novelty soon wears out.