Take them at their word., if they believe they are a women then they are. Disagreeing is saying they are a lair, it's not an opinion what they are or not.
So in the words of last week's Sunday Times article, you would like me to pretend to believe things I know not to be true?
There is no problem whatsoever in someone dressing, naming, defining themselves however they choose, and living however they choose. The problem comes when their actions impinge on and disadvantage other people. I see another poster has already asked, but what would you suggest doing with all the female people who would have no provisions, at all, including health care, refuges, public toilets etc, in order that some males may take their preferred choice from all the provisions?
You're saying you care about people and their individual feelings and needs, so what happens to them?