Girls treated with "puberty blockers" i.e. chemotherapy drugs (lupron) for precocious puberty had lower IQ afterwards.
The problem is that lupron is tested and approved for use against prostrate cancer etc. It is being used off-label to "treat" gender nonconforming behaviour in childhood.
Common side effects:
redness/burning/stinging/pain/bruising at the injection site,
hot flashes (flushing),
increased sweating,
night sweats,
tiredness,
headache,
upset stomach,
nausea,
diarrhea,
constipation,
stomach pain,
breast swelling or tenderness,
acne,
joint/muscle aches or pain,
trouble sleeping (insomnia),
reduced sexual interest,
vaginal discomfort/dryness/itching/discharge,
vaginal bleeding,
swelling of the ankles/feet,
increased urination at night,
dizziness,
breakthrough bleeding in a female child during the first 2 months of leuprolide treatment,
weakness,
chills,
clammy skin,
skin redness,
itching or scaling,
testicle pain,
impotence,
depression,
increased growth of facial hair, or
memory problems.