Has anyone NOT regained weight after stopping WLI?

[gettingalife]

I’ve just read the responses to another thread about what happens when you stop WLI. The majority or people say they’ve regained all weight lost. This is so depressing.

I’m at my target weight now, after losing 3 stone on 5mg, and am terrified of regaining when I stop. I’ve injected 2.5mg for the last 2 weeks and already feel my appetite increasing. I’m tracking calories (1500 - I’m 5ft 1), run 5k 3x a week and walk at least 10,000 steps a day so I’m doing what I should (I think?). Anyone not regained? And what have you done?

Basically take a gap at some point and then restart at 2.5mg.

Because her appetite will increase so she will want to eat more than 1500 . That’s the whole issue. The jabs reduce appetite so people eat less and don’t think so much about food.

Maybe start another thread and ask people to help you understand this? It would be good for this thread to stay focused on ops topic

Is this any different to asking
Has anybody else not gained weight after stopping a diet?
I think it depends what you do after stopping wli.
They work whilst you take them and for those with large amounts of weight to lose they are very useful.
There is no claim made that they keep working after you stop taking them.
Even bariatric surgery is no bar to regain if people eat more calories than they require.

Sooooo………let’s get back to the original topic. Any more success stories of maintaining weight after coming off folks? I’ve loved hearing the positive ones.

I'm similar. Going into perimenopause young caused me to go into non neoplastic hypercortilism (pseudo Cushing's) and then eventually because i still wasn't on hrt i went into sick euthyroid syndrome. I gained 6.5 stone in this time, and HRT wasn't enough on its own to reverse things. Mounjaro has done that, and i feel better than i have done since i was in my early 30s. According to my endocrinologist this is how my endocrine system reacts to physiological stress. Since I've got no way of controlling that I'm not risking it and will be staying on the lowest possible maintenance dose of mounjaro i can get away with.

The only thing about it that bothers me is the cost. I'm on other long-term medication (Apixaban) that concerns me (risks) and inconveniences me (timing) far more than a weekly injection of mounjaro.

I think it’s going to come down to mindset which would need to be intentional and likely include most of the following (I’m still taking low dose but will eventually come off). If you just stop taking it and go back to old way of eating clearly will gain weight

prioritising wholefoods, cutting UPFs
eating over 100g protein a day
keeping carbs under around 100g a day
rebuilding muscle lost during the weight loss phase
intentional movement (steps and cardio)
weighing yourself regularly and tracking calories if weight creeps up
an element of time controlled eating

When I were on the jabs I never ate properly, just ate what I wanted but in very small amounts.

the sight of food used to turn my stomach, I would walk around a supermarket and hate putting food in the trolly, just hated the sight of it.

when I came off them, that’s when the real learning about food came in.

i track and weigh everything, yes i get cravings but i have to ignore them. You have to learn to say no.

it is hard, but the thought of going back 6.4st heavier is enough for me to stick to my calories.

ive also had a tummy tuck since stopping the jabs and that has been a big drive for me to stay at target.

many people are using the jabs so they don’t have to learn self control, there’s a woman I know who’s using them to eat nothing. She’s done from 15 stone to 7 stone and a pharmacist who sees her in person is still prescribing them.

she won’t come off them, she won’t eat properly as she doesn’t want to gain weight.

So interesting about shopping for food. Im not on WLBs but I find the same feeling when I food shop on a full stomach. Good tip for everyone actually, stops you putting random crap you fancy in.
Your friend will die if she doesn’t eat!

No apparently after the jabs people gain weight 4X faster than they do after a diet.

According to one study. According to another the majority kept the weight off or lost a bit more.

It really makes me mad that pharmacists are still prescribing it to her, they have a duty of care when prescribing medication and they deserve to be reported for it as they’re prescribing something that is allowing her to starve herself.

the weight loss jabs give you a full feeling all the time which is the same as when you’ve had a big dinner.

People are allowed to comment about different topics that come up in threads, not only the original post.

😆 of course you’re ‘allowed’!!

Can you link your source please?

Just google it!

NIHR-funded research, led by the University of Oxford, has found that people who come off weight-loss injections such as semaglutide (Wegovy) and tirzepatide (Mounjaro) can regain the weight they’ve lost 4 times faster than those who use traditional dieting and exercising.

If that’s true, I’d assume it’s because they go from no food noise to it being back with avengeance and get a bit out of control.

@Sweetiedarling7 this is an article about the research with a link to the research itself.

https://www.theguardian.com/society/2026/jan/07/weight-loss-jabs-regain-two-years-health-study

So, weight lost on GLP1s was higher but regain was also higher at 0.4kg per month compared to 0.1kg per month.

Here's another study from the US which showed a different result, that the majority of people (about two thirds) either maintained their weight loss or lost a little more.

https://www.reuters.com/business/healthcare-pharmaceuticals/many-patients-may-keep-off-lost-pounds-after-stopping-glp-1-us-data-suggests-2026-01-22/

The first study has an odd result, an average if 8kg weight loss, when real world stats would show significantly more. I think th4 difference is the first reviews trial data and other papers, the second looks at real world.

Thank you, how kind.

Irrespective of this study weight loss injections are more effective than behavioural programmes for a huge number of people who are very seriously overweight.

Otherwise those of us who have tried innumerable other such methods to lose weight wouldn’t be paying large amounts of money for mounjaro etc.

Whatever any study on regain shows, many of us wouldn’t be in a position to even worry about regain without wli.

I also think that regain depends on what you do. Obviously if you return to previous habits the weight etc will return but many of us have only been able to change our lifestyles thanks to wli and will maintain these new habits afterwards.

You are a great example of how it should work and how to maintain after. But most won’t be like that. So will need to be on it forever

My last jab was Feb 15 2025, BMI at the time was 24.8 and it’s currently 23.1 . I’ve initially gained a few lbs but I’ve gone on to lose more weight without actively trying too hard to. I always intended to lose more so that I have a buffer for things like Xmas, holidays etc and that’s what I’ve done. I eat 3 meals a day and snack mostly on fruits and vegetables. I exercise 5 days a week, mainly strength training. (I was only on MJ for 4 pens -20 weeks and I’ve been off for about 50 weeks). My new lifestyle is my new normal, all routine now and I’m enjoying every moment.

Thanks so much for linking the Reuters article - super interesting and encouraging

@Wickedlittledancer yes, I’ve lost 66kg so a little bit more than the average of 8kg in the first study. If I regain at a rate of 0.4kg a month it would take me 165 months to regain all the lost weight, which is 13 years and 9 months. Perhaps the suggestion is that the more weight you lose the faster the regain, though? Unsure what to make of it really, other than I fully intend never to regain even a fraction of the weight lost, however I need to manage that.