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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

Coming off the Jabs - please tell me what happened?

258 replies

coconuttyz · 24/01/2026 18:12

I’ve been off Mounjaro for 2 months now. I got down to my target and started to worry about the injections so decided to stop - I’ve gained 5lbs in that time.
Currently trying to maintain by counting calories (1350 a day) 10,000 daily steps plus running 5K x3 times a week.
Was anyone able to maintain following a similar pattern?
I’m sure the 5lbs gained has gone straight to my stomach and hips, but otherwise I still feel quite lean.

Any advice and tips welcome!

TIA Flowers

OP posts:
Clefable · 26/01/2026 13:45

What was also interesting discussing with my provider was they were interested in my history of being overweight when discussing maintenance. My weight gain was almost entirely post my two pregnancies in the last 6-7 years, I wasn’t overweight as a child or teenager or in my 20s, and the pharmacist I spoke to said that would probably stand me in better stead coming off MJ, because my weight gain was more circumstantial (pregnancies, PND and my mum being diagnosed with a terminal illness and dying). Whereas for people who have struggled with weight since childhood, there’s probably more going on there in a a physiological sense that the medication needs to help regulate.

I needed basically the appetite suppression to overhaul my diet and get used to eating well and healthy portions again, which I did and now my lifestyle is very different. I’m not sure I needed some of the other benefits of the medication in the way others do.

SilenceInside · 26/01/2026 13:53

I think your searching skills surpass mine, @Wickedlittledancer

2.5mg is a non-therapeutic dose, let's say. However, regardless of what it is labelled, on every trial, people lost weight on that dose. In the real world, many people continue to lose weight on that dose if they stay on it past the first 4 weeks, as each person's individual circumstances and response will clearly vary.

We know that 2.5mg weekly on treatment initiation for the first 4 weeks will result in more weight lost than placebo. It is clear that continuing on 2.5mg would likely result in more weight lost than placebo, on average.

If people want to continue on 2.5mg because they are losing weight consistently, then it is effective for them, despite not being considered a therapeutic dose level. I don't see the point in telling people that it's not a therapeutic dose level, if it's producing consistent weight loss for them. It's an irrelevant bit of information, as it's not about them as an individual.

I agree that taking a dose of 2.5mg or less every 4, 6 or even 9 weeks apart is fairly pointless, as you will never be on a stable dose and all the medication will be out of your system before the next injection. You'll get a week of noticeable effects and then negligible impact for the rest of the time.

ThrowingDi · 26/01/2026 14:44

Ooof, today I am struggling with willpower. For context my BMI was 20 and I’ve been maintaining it without MJ for almost a year but gained a bit of weight over Christmas. I’m trying to lose 3-4 kg to get back to BMI 20.

for breakfast (8am) I had a fried egg, half a cucumber diced and a spoon of cream cheese.

then for lunch (12:30) I had an apple and a few of those mini Tony’s chocolates from a Xmas gift. I have also drunk peppermint tea and infinite water throughout the day.

and now I am really wanting more food, but I may as well just wait until dinner. Definitely miss MJ during moments like this. I don’t feel hungry or starving or anything, but simply can’t stop thinking about what I’m having for dinner! I might just snack on some veg but I wish I could just not graze throughout the day and stick to meal times.

soupyspoon · 26/01/2026 14:49

Wickedlittledancer · 26/01/2026 13:26

But that’s not therapeutic.

What is the point of you keep repeating this, are you on auto pilot or something?

It is working for some people at that level, ergo it is therapeutic for THEM

To keep quoting this or that study at this time when it hasnt been studied over the long term, doesnt negate people's experiences

As I said, we'll see what the information give us in about 5 years time

ThatAzureCat · 26/01/2026 15:04

ThrowingDi · 26/01/2026 14:44

Ooof, today I am struggling with willpower. For context my BMI was 20 and I’ve been maintaining it without MJ for almost a year but gained a bit of weight over Christmas. I’m trying to lose 3-4 kg to get back to BMI 20.

for breakfast (8am) I had a fried egg, half a cucumber diced and a spoon of cream cheese.

then for lunch (12:30) I had an apple and a few of those mini Tony’s chocolates from a Xmas gift. I have also drunk peppermint tea and infinite water throughout the day.

and now I am really wanting more food, but I may as well just wait until dinner. Definitely miss MJ during moments like this. I don’t feel hungry or starving or anything, but simply can’t stop thinking about what I’m having for dinner! I might just snack on some veg but I wish I could just not graze throughout the day and stick to meal times.

Edited

I think this is a classic deprivation diet though! Most people would struggle with will power if that’s a classic day of eating., if snacking on veg helps then why not? that’s not what causes people to put on weight really, I don’t think anyone got fat through eating plentiful veggies. What was your pre MJ weight?

ThrowingDi · 26/01/2026 15:09

ThatAzureCat · 26/01/2026 15:04

I think this is a classic deprivation diet though! Most people would struggle with will power if that’s a classic day of eating., if snacking on veg helps then why not? that’s not what causes people to put on weight really, I don’t think anyone got fat through eating plentiful veggies. What was your pre MJ weight?

I don’t see it that way. Firstly I am short so my daily calories are lower than average for maintenance let alone weight loss. Secondly, I was naturally slim, then gained weight in a short period/over 2 years, then took MJ. So BMI 20 is my “normal”, I’ve been this weight before MJ/before I gained. At my biggest I was BMI 32. I don’t really want to go back there so I’m trying to knock it on the head now.

There’s still the rest of the day to go, so although I haven’t eaten loads yet, I still do plan on eating more later. I’m not done yet! If I’m being honest I feel like I’ve eaten enough to feel satiated, it’s more grazing as opposed to actual hunger or deprivation as you’ve put it.

thetallfairy · 26/01/2026 15:22

So guys I have a golden dose in one pen and a full 10mg pen left

I want to start to cut down on my use as I have hit goal weight

I am petrified

Should I go down slowly this month? Order new pens at lower dose?

Thanks all

Sorry if this is a stupid question

MeridaBrave · 26/01/2026 15:28

thetallfairy · 26/01/2026 15:22

So guys I have a golden dose in one pen and a full 10mg pen left

I want to start to cut down on my use as I have hit goal weight

I am petrified

Should I go down slowly this month? Order new pens at lower dose?

Thanks all

Sorry if this is a stupid question

How about trying 7.5mg for a few weeks to see how you feel?

ThatAzureCat · 26/01/2026 15:41

ThrowingDi · 26/01/2026 15:09

I don’t see it that way. Firstly I am short so my daily calories are lower than average for maintenance let alone weight loss. Secondly, I was naturally slim, then gained weight in a short period/over 2 years, then took MJ. So BMI 20 is my “normal”, I’ve been this weight before MJ/before I gained. At my biggest I was BMI 32. I don’t really want to go back there so I’m trying to knock it on the head now.

There’s still the rest of the day to go, so although I haven’t eaten loads yet, I still do plan on eating more later. I’m not done yet! If I’m being honest I feel like I’ve eaten enough to feel satiated, it’s more grazing as opposed to actual hunger or deprivation as you’ve put it.

No fair enough, it sounds like you are fairly unique though, going from a typical bmi of 20 to over 32 in 2 years is pretty unusual , and it’s being curious as to why that was. I think in winter ,when we have natural biological drivers towards eating certain foods, rather than putting ourselves down by thinking about willpower - it’s thinking seasonally, so having a stewed or baked whole apple with a few raisins is going to be more satisfying then an apple with chocolates, equally having some portioned vegetable soup in the freezer ready to heat up is going to be more satisfying then cold food at this time of year. Once you are off MJ it’s thinking what meets the sensory aspects of why humans eat or over eat rather than just the simple calorific/ nutritional value of food.

SilenceInside · 26/01/2026 15:44

@thetallfairy I would probably order another pen at the same dose, 10mg, as that gives you some flexibility and leeway for future doses. Then I would plan for a period of a few months where you try stepping down doses and maintaining. If you continue to lose weight then continue to step down, and so on.

HappyToSmile · 26/01/2026 15:47

Are you sure you're only eating those calories? I would find your recommended calorie intake (loads online, the james smith one is good) and then properly track your calories. That will mean weighing stuff, not guessing.

Lollylavender · 26/01/2026 17:01

ThrowingDi · 26/01/2026 14:44

Ooof, today I am struggling with willpower. For context my BMI was 20 and I’ve been maintaining it without MJ for almost a year but gained a bit of weight over Christmas. I’m trying to lose 3-4 kg to get back to BMI 20.

for breakfast (8am) I had a fried egg, half a cucumber diced and a spoon of cream cheese.

then for lunch (12:30) I had an apple and a few of those mini Tony’s chocolates from a Xmas gift. I have also drunk peppermint tea and infinite water throughout the day.

and now I am really wanting more food, but I may as well just wait until dinner. Definitely miss MJ during moments like this. I don’t feel hungry or starving or anything, but simply can’t stop thinking about what I’m having for dinner! I might just snack on some veg but I wish I could just not graze throughout the day and stick to meal times.

Edited

It IS hard but doable. Drinking peppermint teas or any herbal teas is a great idea! Enjoy your dinner .

ShawnaMacallister · 26/01/2026 19:43

ThrowingDi · 26/01/2026 14:44

Ooof, today I am struggling with willpower. For context my BMI was 20 and I’ve been maintaining it without MJ for almost a year but gained a bit of weight over Christmas. I’m trying to lose 3-4 kg to get back to BMI 20.

for breakfast (8am) I had a fried egg, half a cucumber diced and a spoon of cream cheese.

then for lunch (12:30) I had an apple and a few of those mini Tony’s chocolates from a Xmas gift. I have also drunk peppermint tea and infinite water throughout the day.

and now I am really wanting more food, but I may as well just wait until dinner. Definitely miss MJ during moments like this. I don’t feel hungry or starving or anything, but simply can’t stop thinking about what I’m having for dinner! I might just snack on some veg but I wish I could just not graze throughout the day and stick to meal times.

Edited

Of course you're starving, you ate an apple and some chocolate for lunch 🫤 that's not aspirational whether on mj or not! How are you expecting to be able to eat only meals when your meals are about 100 calories (breakfast) or just sugar (lunch)

Alltheyellowbirds · 26/01/2026 19:52

ShawnaMacallister · 26/01/2026 19:43

Of course you're starving, you ate an apple and some chocolate for lunch 🫤 that's not aspirational whether on mj or not! How are you expecting to be able to eat only meals when your meals are about 100 calories (breakfast) or just sugar (lunch)

Edited

This. Chocolates and an apple is not a meal! Please look after your body.

MeridaBrave · 26/01/2026 20:07

ThrowingDi · 26/01/2026 14:44

Ooof, today I am struggling with willpower. For context my BMI was 20 and I’ve been maintaining it without MJ for almost a year but gained a bit of weight over Christmas. I’m trying to lose 3-4 kg to get back to BMI 20.

for breakfast (8am) I had a fried egg, half a cucumber diced and a spoon of cream cheese.

then for lunch (12:30) I had an apple and a few of those mini Tony’s chocolates from a Xmas gift. I have also drunk peppermint tea and infinite water throughout the day.

and now I am really wanting more food, but I may as well just wait until dinner. Definitely miss MJ during moments like this. I don’t feel hungry or starving or anything, but simply can’t stop thinking about what I’m having for dinner! I might just snack on some veg but I wish I could just not graze throughout the day and stick to meal times.

Edited

Seriously? Of course starving if that’s what you are eating. Need to eat 30-35g of protein and 10g of fibre for each meal. The egg is like 6g protein. And “lunch” has pretty much no protein. Your diet is a sure way to erode your muscle mass. The chocolates have no nutritional value so need to be extra to lunch (if you have spare calories) not an “instead of”.

Gettingbysomehow · 26/01/2026 20:12

Ive put nothing back on because I weigh myself everyday and if I put on a pound then I lose a pound. Don't let it get to a stone.
Luckily I don't have hormonal days as Im 64 but you have to be super strict not to put lost weight back on however you lose it and most people don't want to live like that.
I don't drink alcohol or eat takeaways. Id rather be thin. I refuse to go back to 15 stone. I was so miserable.

thetallfairy · 26/01/2026 20:41

SilenceInside · 26/01/2026 15:44

@thetallfairy I would probably order another pen at the same dose, 10mg, as that gives you some flexibility and leeway for future doses. Then I would plan for a period of a few months where you try stepping down doses and maintaining. If you continue to lose weight then continue to step down, and so on.

Ok thank you

Lollylavender · 26/01/2026 21:04

As long as her dinner is nutritious all is good. We don’t need 3 meals a day! And her breakfast was healthy as well as the apple at lunch. Sounds great to me!

ShawnaMacallister · 26/01/2026 21:12

Lollylavender · 26/01/2026 21:04

As long as her dinner is nutritious all is good. We don’t need 3 meals a day! And her breakfast was healthy as well as the apple at lunch. Sounds great to me!

An egg, some cream cheese and an apple isn't healthy or great when it encompasses 2 whole meals.
Sure, she may be eating a generous 900 calorie high protein dinner to complete her day but I really doubt it, the way she's avoiding 'snacking on veg' and berating herself for being hungry.

MeridaBrave · 26/01/2026 21:32

Lollylavender · 26/01/2026 21:04

As long as her dinner is nutritious all is good. We don’t need 3 meals a day! And her breakfast was healthy as well as the apple at lunch. Sounds great to me!

Not really. Her protein intake is likely to be extremely low and even if dinner is a massive amount of chicken there is a limit on how much the body can absorb in one meal. Long term this is a Recipe for muscle loss and frailty. 2 meal is ok but both should contain 35-40g protein.

AmythestBangle · 26/01/2026 23:38

I have been on 2.5 for six months. It is definitely not "subtherapeutic".

maz99 · 27/01/2026 00:19

coconuttyz · 24/01/2026 20:34

@ShawnaMacallisterIs it really very low? My BMI is 22.3 - I don’t feel hungry and I’ve been counting those calories for 8 weeks now. Maybe the ‘food noise’ is taking longer to return for Me. I wouldn’t consider it setting myself up for failure, I’m trying very hard and plan all my meals accordingly.

How tall are you? Because 1350 is quite low for someone that is active.
This is why I keep my calories high (above 1500) whilst losing weight... yes it's slower, but I will ensure that I don't damage my metabolism and my maintenance calories won't be low.

thetallfairy · 27/01/2026 10:07

AmythestBangle · 26/01/2026 23:38

I have been on 2.5 for six months. It is definitely not "subtherapeutic".

Do you mind if I ask is that weekly?

Do you order a 2.5 pen per month?

Sorry I am just thinking ahead of what to do 😬😬😬

Corknut · 27/01/2026 10:50

Lollylavender · 25/01/2026 18:17

But why won’t she exercise or eat healthily? Not only to lose weight but to build muscle and be healthier?!

why are depressed people depressed? I don’t know the answer to this except she (had) been morbidly obese my whole life and obviously felt it wasn’t possible without medication?

Justnamechangedagain · 27/01/2026 13:32

Clefable · 26/01/2026 13:34

I think there is a lot still to be unpicked on how different doses work in different people. I lost all my weight on 3.75mg, 5 was way too strong for me, I could barely eat and it gave me the raging shits, but I lost 5 stone on 2.5-3.75 before I came off. It was definitely having the effects as stated (evidenced when I got Norovirus and threw up recognisable food I’d eaten 24+ hours earlier which was a bit grim!) whereas for other people they need to get up to the higher doses before they notice anything. But even on my first dose of 2.5, within four hours my appetite was gone, I remember thinking how wild it was!

Some people seem to be far more sensitive/super responders while others need to go up to 15mg, and I wonder if that has some influence on how easy it is to come off them. I think there’s probably a lot more to discover!

I found same. I never went above 5mg and am currently taking 2.5 every month or so. I find the effect remarkable. Serious appetite reduction.