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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

November 2025 Mournjaro starters

1000 replies

Nearlyamumoftwo · 01/11/2025 15:05

I've just collected my first supply and wondered if anyone wanted to join in with the journey! I'm on 2.5 and I'm 14st1, goal weight is 12 stone as that is my pre baby weight and we'll see how I feel once I've reached it!

any tips on when to take it each week? I'm going to avoid alcohol and even though snacking is my weakness I think purchasing a supply is going to make me stop in a weird way. Any tips gratefully received and if anyone wants to join the journey for support and no judgment here's the place!

OP posts:
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RoundandSad · 05/12/2025 12:32

@SexyFrenchDepression thanks I think I looked at them before and I was still really surprised at how much it dropped off day five I might not have understood steady state correctly

Well anyway, I've done 3.75 from the new pen

I could not force the old one so that kind of made my decision for me. I don't think I want to start faffing about with syringes.

I probably need to read less about all this rather than more because every single thread, here and Reddit, people are losing a lot, even the people who only just scrape into the criteria

Well, it's done now. Hopefully, I won't feel as rubbish as I did last weekend.

SexyFrenchDepression · 05/12/2025 12:36

RoundandSad · 05/12/2025 12:32

@SexyFrenchDepression thanks I think I looked at them before and I was still really surprised at how much it dropped off day five I might not have understood steady state correctly

Well anyway, I've done 3.75 from the new pen

I could not force the old one so that kind of made my decision for me. I don't think I want to start faffing about with syringes.

I probably need to read less about all this rather than more because every single thread, here and Reddit, people are losing a lot, even the people who only just scrape into the criteria

Well, it's done now. Hopefully, I won't feel as rubbish as I did last weekend.

The syringes are almost easier than the pen itself but I do get it, its an extra step isnt it.

There is a brilliant thread on here called 'plodders'. It might be worth you taking a read. TBF you're early days and low dose so you may well start ramping up soon anyway but that thread may be reassuring to you.

I hope you dont get too many symptoms. I am hoping I dont get the nausea again as its horrible.

SexyFrenchDepression · 05/12/2025 12:43

@RoundandSad I checked my recent graphs, so compared to the week before at the lowest levels (day 6) it had increased from last week at the same point so it definitely builds up. Same as the week before so lowest point so far has been increasing by 0.2mg a week. Highest point on 2.5mg jab last week was 3.8mg, lowest point 1.7mg. It will be interesting to see what happens with increased dose. Going into day 5 last week was around 2.3mg so not that low really.

TaffyTabby · 05/12/2025 18:07

@RoundandSad yes sorry steady state doesn’t mean the graph is flat, you’re right in that it always goes up and then tapers off. It just means that after state is reached that the peaks and troughs will be the same levels every dose, whereas in the earlier weeks your troughs and peaks wouldn’t have been as high. I dunno if I’ve explained that well!

Wethers121 · 05/12/2025 19:35

Just ordered my new pen and decided to stick to 2.5. My suppression and lack of appetite has significantly increased in week 3 and now into week 4. Today I had my first day where I totally forgot to eat lunch (and no breakfast). I did have a healthy snack to compensate as was too close to evening meal to eat. But I was surprised how different it is now to the first two weeks.

I’ve only lost 7lb so far but my DH has noticed and I can too. My face has really slimmed down.

BlueMum16 · 05/12/2025 19:53

Starting weight 15 stone 10 (size 18)
Target weight maybe 11 stone (size 12)
Current weight 15 stone 3.4lbs

NSV I need a new belt (or a tighter hole adding to this one) and jeans now feel nice and lose too.

So after taking my 4th dose of my first pen last Thursday and posting about no side effects I felt queasy all weekend and then hardly any suppression this week. I've had chocolate and wine and lunch everyday whereas before I was just grabbing a healthy snack.

Glad to have a slight loss today which I didn't actually realize until doing this post but disappointing compared to how others are doing but need to keep reminding myself it's my journey, not yours.

As I'm on Wegovy my new pen is 0..5 now but taking 0.4 over 5 weeks partly not to double the dose due to side effects but also to spread out the cost and get 5 weeks from the pen.

As I usually take on a Thursday I've moved to today this week as I want to manage to miss Christmas day/Boxing day if I can. I think I'll need to take Saturday next week as I'm out on Friday.

Looking forward to being 14 stone something in next few weeks, would just like to be well under for Christmas 🤞

TaffyTabby · 05/12/2025 19:58

@BlueMum16 I’m similar starting weight to you and same goal. I’m 5ft5.

I am down another lb as of this morning, but still pretty slow going these last two weeks. It’s so hard not to compare with others!

Springbaby2023 · 05/12/2025 21:02

NSV for me today, someone took a picture of me and I can’t believe how much slimmer my face looks, even though I’m only about 7lb down so far! Was really chuffed.

PatheticDistraction · 06/12/2025 07:59

I'm about to do injection number 5 - and moving up to 5mg, bit nervous of the side effects, but hoping for more suppression.

I've fallen off the wagon somewhat this week as it was my 40th birthday - but I ate so, so much less than I would have done - it's kind of a miracle. I did find I felt quite unwell after any alcohol, so going to stop drinking anything now. I may skip my weigh in this week, as I suspect I won't have lost anything & I don't want to feel demoralised.

NoNewClothes · 06/12/2025 11:18

Belated happy birthday @PatheticDistraction!

I was out for dinner last night, didn’t finish my plate but woke at 3am with really bad heartburn. Lesson learnt. Took 4th dose (2.5mg) on Thursday.

I’ve got my next pen which is 5mg but still unsure whether to stick to 2.5mg especially having a few social eating plans in the diary between now and Christmas.

TaffyTabby · 06/12/2025 13:14

@PatheticDistraction happy birthday! Did you do anything special to mark 40? I’m not far behind you. I’d like to have a big party. We eloped for our wedding so I feel like I’m owed a party.

My news is I’m slooooowly inching toward my first goal, I actually saw 14 on the scale today but then it equalised to 15 st 0.2

I think I’m an outlier here cause I weigh daily. But I use the happy scale app that keeps an average of the fluctuations.

NoNewClothes · 06/12/2025 13:26

I also weigh most days and use happy scale. Bit of a plodder with weight loss, 6 lbs down since starting, just finished first pen - but if you have me 1-1.5 pounds a week for the next 20 weeks I’d take it!

SexyFrenchDepression · 06/12/2025 13:49

TaffyTabby · 06/12/2025 13:14

@PatheticDistraction happy birthday! Did you do anything special to mark 40? I’m not far behind you. I’d like to have a big party. We eloped for our wedding so I feel like I’m owed a party.

My news is I’m slooooowly inching toward my first goal, I actually saw 14 on the scale today but then it equalised to 15 st 0.2

I think I’m an outlier here cause I weigh daily. But I use the happy scale app that keeps an average of the fluctuations.

My PT recommended every other day for me for same reason. I prefer twice a week on set days but occasionally can't resist checking in between days haha!

So close to that next number down though, its such a nice feeling.

SexyFrenchDepression · 06/12/2025 13:52

End of week 5 for me today, have lost over 16lb in total, average of 3.3lb a week (although nearly 6lb in first week).

SW 12 stone
CW 10 stone 11.6
TW 9-9 1/2 stone

Have actually found xmas dos more enjoyable as havent worried about overeating and not fitting in clothes over xmas.

RoundandSad · 06/12/2025 17:22

NoNewClothes · 06/12/2025 13:26

I also weigh most days and use happy scale. Bit of a plodder with weight loss, 6 lbs down since starting, just finished first pen - but if you have me 1-1.5 pounds a week for the next 20 weeks I’d take it!

Are you like me? I'm a month in and I'm
only 5lb down.

I'm aware of the thread for slow losers, but I was thinking it would do me good to think about this less

I wasn't very well after my jab yesterday (3.75) like not really ill but felt nauseous so I was glad I didn't have to go out took Pepto-Bismol

I felt pretty bad until lunchtime just completely drained but I seem to be okay now fingers crossed because we have to go out later and tomorrow

There is no good time to take this injection because either you're facing work or you're facing weekend plans

I'm glad I only signed up for the three months. Did anyone else sign up to a plan or did you all just decide to buy each month

I looked up some sample eating plans on this and I was shocked at how little is even being recommended to eat

Well, it seems like very little to
me but I'm overweight so I'm not the best person to ask!

Springbaby2023 · 06/12/2025 20:00

@TaffyTabby I weigh most days, just only recording once a week. I like to see how it fluctuates, I always way heaving the day after playing netball which I’m guessing is water retention.

Wethers121 · 06/12/2025 22:02

Springbaby2023 · 05/12/2025 21:02

NSV for me today, someone took a picture of me and I can’t believe how much slimmer my face looks, even though I’m only about 7lb down so far! Was really chuffed.

This is the same for me as well! 7lb down and my face has slimmed so much. I did read on another thread this may be due to the jabs reducing inflammation?

Springbaby2023 · 07/12/2025 09:04

How has everyone found stepping up a dose?

I’m due to jab tonight, first one from new pen and still undecided as to whether to do 3.75 or just go straight for 5mg.

@Wethers121 Ooh interesting, must be some truth in that as I can’t see half a stone making much difference.

SexyFrenchDepression · 07/12/2025 09:14

@Springbaby2023 I went up to 3.75 pn Thursday. So far ive been OK, I wasnt brave enough to go up to 5, I actually would have stayed on 2.5 I think if I hadn't bought a 5mg pen already. Felt rough the day after but I came on also so it could have been that as I suffer badly. Felt a bit dizzy and queasy yesterday on the odd time but just ate something when that happened. Generally feel ok though.

I know I need to force myself to eat more some days as I really dont want to get the nausea I had in week 2/3 last jab.

OhCobblers · 07/12/2025 09:21

@SexyFrenchDepression or anyone else I’m sorry for being extra stupid but could you explain how I do this? I’m reluctant to go to 5mg as it would be over Xmas and worried about side effects with a full house! Thank you!

putthehamsterbackinitscage · 07/12/2025 09:32

@OhCobblersafter you have primed and the number is back to zero, you turn the end of the pen slowly so you can count each click. Depending on what dose you want.

full dose = 60 clicks
half dose = 30 clicks

so to get 3.75 from 5 mg pen it is 45 clicks.

and any other variations = dose you want / full dose * 60

eg 4 mg / 5 mg * 60 =48 clicks

SexyFrenchDepression · 07/12/2025 09:34

OhCobblers · 07/12/2025 09:21

@SexyFrenchDepression or anyone else I’m sorry for being extra stupid but could you explain how I do this? I’m reluctant to go to 5mg as it would be over Xmas and worried about side effects with a full house! Thank you!

Its just 45 clicks on the pen each time rather than 60. I felt the same as had quite bad nausea early on and it started to get me down a bit some days.

Springbaby2023 · 07/12/2025 09:38

@OhCobblers that’s my concern too, I think if it was any other month I’d have gone straight up to 5, but with it being Christmas I am tempted to try 3.75

Springbaby2023 · 07/12/2025 09:49

@SexyFrenchDepression Do you feel like your suppression has increased on 3.75 to 2.5?

SexyFrenchDepression · 07/12/2025 09:53

Springbaby2023 · 07/12/2025 09:49

@SexyFrenchDepression Do you feel like your suppression has increased on 3.75 to 2.5?

It is a bit more for sure but it was pretty suppressed on 2.5mg anyway, however I was definitely getting a bit hungrier by day 6/7 before. Will see how this goes by then.

I am not sure I needed to increase but quite a few people said they were fine on 2.5mg till week 6 and then had little suppression after that so wished they'd gone up.

I need to really focus on keeping good energy levels as I am so conscious of losing muscle mass as I am still losing 3lb+ a week.

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