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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

Weight gain on mounjaro

232 replies

Polkadotdash · 17/01/2025 10:32

Any else experience this? I’m just starting my 4th week on 2.5mg. I lost a few pounds in my first week on it, but these are back on now. I’ve had no effects at all from the injections - good or bad. I’ve already bought the 5mg dose to start next week, but I’m starting to wonder if it’s worth the cost. I bought from a big online pharmacy so I’m assuming that I haven’t been sent a placebo or anything. But it’s really doing nothing for me, apart from costing me money! Am I alone in this?

OP posts:
Shrinkingrose · 17/01/2025 10:35

No, you won’t be alone, 15 percent of people it has no impact on at all it doesn’t work for them. So I’d try the 5 and if it doesn’t work, then stop, but 5 maybe might work. Good luck.

2,5 is just initiate treatment, it’s not even a full dose, and is not supposed to cause weight loss, of course it does in many but in it not doing so, you’re far from alone.

SnarkSideOfLife · 17/01/2025 10:35

You’ve got to stick with it and go up the doses. 2.5mg isn’t at a therapeutic level. Some people it will work for but others won’t see a benefit until higher doses. I’m on 15mg and only get very slight nausea a couple of times a week if I’ve eaten too much. But I can easily eat a whole pizza still. So my weight loss has been slow compared to others. Been on it since March time I think and have lost 2 stone so over time I’m getting there. But often two steps forward and a step back and feels like hard work.

Theresacatinmykitchenwhatamigonnado · 17/01/2025 10:36

Well 2.5 is just the 'warm up' to get your body used to it, although some people do lose well on that dose (I lost 10lbs the first month.)But what are you eating? Have you changed your eating habits? The injection itself does not magically reduce your weight, you do have to put in some effort too.

Speedweed · 17/01/2025 10:36

You're on the starter dose, so it's likely it's just not going to be effective for you until you reach a higher dose. That's the case for many people, although it's probably hidden to an extent because many people tend to start diets at the same time so willpower and a strict diet starts their weightloss.

You'll know it when it kicks in. Until that point keep taking the injections, and go up to the next dose each month. Just keep going!

Shrinkingrose · 17/01/2025 10:40

Speedweed · 17/01/2025 10:36

You're on the starter dose, so it's likely it's just not going to be effective for you until you reach a higher dose. That's the case for many people, although it's probably hidden to an extent because many people tend to start diets at the same time so willpower and a strict diet starts their weightloss.

You'll know it when it kicks in. Until that point keep taking the injections, and go up to the next dose each month. Just keep going!

This, most people start a diet or healthy eating plan at the same time, and the low dose just enables that. The drug doesn’t just do it for you for most of us. Once you get to the higher doses it has more of an effect.

many are super responders though. But hard to tell how much of that is psychological v the drug.

Ilovethewild · 17/01/2025 10:41

Just to add it’s also a tool not a magic jab, ideally you reduce yr eating, eat more protein, less junk, less alcohol,

it is a long term plan, ideally 1-2 lbs a week

i know it’s hard, we all want to lose quick, but slow is best

letshavetea · 17/01/2025 11:01

Have you revised your diet? High fibre (lots of fruit, veg, seeds, pulses, grains, nuts). Protein (pure form - not shakes, powders ir bars as they’re shown not to work). Lots of water. Good fats - olive oil, Greek yogurt. Water ++++. No UPFs? The Zoe website and podcasts is great for info on this.
Are you exercising or at least walking daily.
Have you joined the thread for the month you started? Good luck.

Polkadotdash · 17/01/2025 12:02

Thanks. It’s useful to hear that those experiencing significant weight loss in the first month are probably due to dietary changes rather than from mounjaro.
My diet isn’t terrible in the first place, but it’s very carb heavy so I’m trying to tackle that. I don’t really drink (maybe a couple of glasses of wine per month) and I don’t eat meat or fish.
I also don’t understand the ‘food noise’ thing. What is that? Does that means constantly thinking about food? If so, I didn’t have that in the first place.
However I am obese with at least three stone to lose so I’m guessing I was hoping for a miracle!

OP posts:
IrisPallida · 17/01/2025 12:19

If you do not change what you are eating then MJ cannot do anything for you. It is perfectly possible to not lose or gain weight if you do not change your calorie intake.

IsItSnowing · 17/01/2025 12:22

With MJ you still need to reduce to a calorie deficit - it just makes it easier. I do best when I check and log what I eat.
There's really nothing wrong with carbs though. I know lots of people prefer low carb and that's great but I'm vegan and my diet is mainly carbs. Wholefoods though not processed. So far I've lost 29lbs so I think it's working.
It's the junk food and processed foods that I've cut. MJ helps with that and I eat less but I still need to be mindful.

DarkForces · 17/01/2025 12:26

You need to be in a calorie deficit to lose weight. Mounjaro can help you by regulating blood sugar and slowing digestion so you don't get the cravings and stay fuller for longer but the old adage of eat less and move more applies. There's lots of tools to calculate the calories you need and then the deficit you need to lose particular amounts of weight. Food logging also helps so you know if you're on track. It's a long hard road but it's made a lot less rough by Mounjaro

TeenLifeMum · 17/01/2025 12:26

I’m on mj but calorie count too. It makes me less likely to binge so enables me to follow the diet I’d struggled with for the last year. I did find that 2.5 worked for 3 weeks then stopped so moved to 5, which was effective but less so on week 4. I’m now on week 1 of 7.5 and it’s working but loss has slowed to 1-2 lbs a week. Overall I’ve lost 22lbs but I’ve had to really keep calories under 1200 a day (I’m quite short).

Polkadotdash · 17/01/2025 12:29

I get that you need to restrict calorie intake and that the benefit that Mounjaro gives you over just willpower is to not be hungry so you eat less. I’m just not experiencing that and still eating around 2000 cals a day. Maybe I will experience hunger suppression on the higher dose. Or maybe it just doesn’t work for me.

OP posts:
Polkadotdash · 17/01/2025 12:33

DarkForces · 17/01/2025 12:26

You need to be in a calorie deficit to lose weight. Mounjaro can help you by regulating blood sugar and slowing digestion so you don't get the cravings and stay fuller for longer but the old adage of eat less and move more applies. There's lots of tools to calculate the calories you need and then the deficit you need to lose particular amounts of weight. Food logging also helps so you know if you're on track. It's a long hard road but it's made a lot less rough by Mounjaro

But then what is MJ adding to cause the weight loss? I know I would lose weight if I only ate 1200 calories a day, regardless of MJ. If it isn’t suppressing my hunger, what is it doing? This is why I find it so confusing.

OP posts:
InfoSecInTheCity · 17/01/2025 12:42

You have to put some effort in as well, you do need to exercise willpower, the Mounjaro just makes that easier and it helps to make your body more insulin sensitive so you process blood sugar better.

I have lost over 3 st on MJ, but I've also tracked my food every day, been eating less calories than my TDEE, added in exercise, reduced carbs, eat much less UPFs, much more protein and drink 2lts water a day.

Polkadotdash · 17/01/2025 12:45

InfoSecInTheCity · 17/01/2025 12:42

You have to put some effort in as well, you do need to exercise willpower, the Mounjaro just makes that easier and it helps to make your body more insulin sensitive so you process blood sugar better.

I have lost over 3 st on MJ, but I've also tracked my food every day, been eating less calories than my TDEE, added in exercise, reduced carbs, eat much less UPFs, much more protein and drink 2lts water a day.

3 stone is amazing. Well done.
Do you think though that all the diet changes would have achieved that anyway or that MJ has helped? I ask that because I’m starting to think that I can save £150 a month on jabs if the answer to weight loss is what it’s always been ‘eat less, move more’.

OP posts:
DarkForces · 17/01/2025 12:45

Polkadotdash · 17/01/2025 12:33

But then what is MJ adding to cause the weight loss? I know I would lose weight if I only ate 1200 calories a day, regardless of MJ. If it isn’t suppressing my hunger, what is it doing? This is why I find it so confusing.

You're on a starter dose to get your body used to it. As you move up the doses you'll find it has more impact. It's not magic. If you prefer to save the money that's fine too

DarkForces · 17/01/2025 12:49

Here is information about how the drug works www.cloudpharmacy.co.uk/online-doctor/weight-loss-treatments/mounjaro-weight-loss-injection/

InfoSecInTheCity · 17/01/2025 12:50

I have lost weight through diet and exercise before, it was extremely hard, I was starving hungry all the time, miserable and felt crap. I'd always fall off the diet because I'd become fatigued from constantly thinking about and talking myself out of eating.

With MJ once I was on 5mg I don't really feel hungry very often, before I'd say no to a piece of cake but my stomach would be rumbling, my mouth watering, now I say no and then forget about the cake.

I track my food to make sure I'm not accidentally eating more calories than I need and just mindlessly snacking. I plan my meals and make sure I'm getting a good selection of vegetables to get plenty of fibre and nutrients.

WeAllHaveWings · 17/01/2025 12:56

Do you think though that all the diet changes would have achieved that anyway or that MJ has helped?

The diet changes alone would probably give similar results. The problem with those suffering from obesity is sustaining those diet changes long term, otherwise if it was really that easy we would have all done it years ago! MJ helps with suppressing appetite to make that easier to do - the diet changes still need to happen.

Those that have previously been obese are very likely to gain weight again in the long term, this is where Mounjaro can also help with the harder task of maintenance. I am likely to be using GLP-1 medications in some form or another for many years.

Motnight · 17/01/2025 12:58

Polkadotdash · 17/01/2025 12:45

3 stone is amazing. Well done.
Do you think though that all the diet changes would have achieved that anyway or that MJ has helped? I ask that because I’m starting to think that I can save £150 a month on jabs if the answer to weight loss is what it’s always been ‘eat less, move more’.

Op I'm not sure if you actually understand how MJ works, which is a bit concerning as you are using it.You need to really look at all the information that your prescriber will have provided you with.

InkHeart2024 · 17/01/2025 13:01

Polkadotdash · 17/01/2025 12:33

But then what is MJ adding to cause the weight loss? I know I would lose weight if I only ate 1200 calories a day, regardless of MJ. If it isn’t suppressing my hunger, what is it doing? This is why I find it so confusing.

It's not adding anything if it's not suppressing your appetite. But as others have said, many people don't get effects at the starting dose. It's up to you if you want to keep trying.

RamblingFar · 17/01/2025 13:02

You need to diet to lose weight, Mounjaro doesn't work like magic. It helps with making it easier to stick to the diet, but unless you change what you are eating, you won't see much impact.

I struggle to overeat 2-3 days after my jab, especially after I've just gone up a dose. But the rest of the week I could easily overeat if I wanted to. I went out for a Christmas dinner a few weeks ago and managed about 3000 calories in 30 minutes, so it's still possible to overeat if you don't stop yourself.

I'm 4.5 stone down on Mounjaro. But I still need to calorie track and watch what I eat. I could probably just have lost the weight calorie tracking, but it's the Mounjaro that helps me actually stick to the diet. That's what makes it worth the money and effort. The less documented bonus side effects of no more joint pain (unrelated I think to the weight loss as it disappeared almost immediately), far fewer chin hairs and hormone issues also make it worthwhile.

Polkadotdash · 17/01/2025 13:25

Motnight · 17/01/2025 12:58

Op I'm not sure if you actually understand how MJ works, which is a bit concerning as you are using it.You need to really look at all the information that your prescriber will have provided you with.

I do understand what it’s supposed to do - make you less hungry, feel fuller, eat less, stick to a diet. However I’ve yet to experience that. That’s what I’m questioning. If the jab doesn’t have any effect on my usual eating patterns, all I’m left with is will power alone. Which I know doesn’t work, hence why I’m obese. Maybe the 5mg will work better for me.

OP posts:
Shrinkingrose · 17/01/2025 13:50

Polkadotdash · 17/01/2025 13:25

I do understand what it’s supposed to do - make you less hungry, feel fuller, eat less, stick to a diet. However I’ve yet to experience that. That’s what I’m questioning. If the jab doesn’t have any effect on my usual eating patterns, all I’m left with is will power alone. Which I know doesn’t work, hence why I’m obese. Maybe the 5mg will work better for me.

Op the poster is clearly responding to your comment on was it diet.

people have said at the start it is diet for many. But that doesn’t mean it is always diet. Hence why the poster questioned if you understood the drug.

you have been told repeatedly you’re on the initiate treatment dose. And you must surely know for most of us as we move up our appetite is suppressed, we don’t think of food, and we feel it is easy to eat within a calorie deficit. This is the drug. It is not willpower. But we still need to make healthy choices. Or we would be unwell.

no one knows if you’re in the 15 percent where it doesn’t work, or you just need a higher dose, neither do you. You need to try the five, if it doesn’t work accept you’re in the 15 percent. If not, you will find you get the same results as the rest of us.

but no, none of us are spunking 200 a month and simply using willpower. Cmon.