Sharing this as it might be relevant and interesting to others. Just had an email exchange with my endocrinologist (Professor at major London hospital, has worked on trials of the meds we're taking - one of the most experienced people with GLP1 in the UK).
I'm 10 weeks in. Have taken 3x 2.5 mg, 4x 3.75 mg, 3x 5 mg. I had 2 days of bad diarrhoea on my second 5 mg dose, but nothing major before or after (the 3rd 5 mg dose seems totally fine).
I asked if I should move up 7.5 mg with my next pen as suppression is not as strong any more.
Response: Stay with 5 mg for one more pen to be sure that the diarrhoea doesn't become a bigger problem. Give the body time to adjust.
Also he was cool with the fact that I titrated up slowly via 3.75 mg.
My read of this: We're playing a long game, people. Slow and steady wins.