Why on earth would she not want to move back to the city where she was born and raised, and where her mother and many of her old friends still live?
Shooting locations have very little to do with where films and TV series are actually 'made' ie where the meetings and decisions are made, where all the power happens. Most auditions are still held in LA (or in London if it's a British show) regardless of where the project is shot. For example The X Files was filmed in Canada, but their CD suite was based in LA and so most actors were cast out of LA and flown to Canada. Meghan's auditions and screen tests for Suits certainly would have been in LA. Game of Thrones filmed in Belfast but they used a famous London-based CD; if you wanted to be on Game of Thrones you'd have to go to London to audition even if you lived in Belfast. Only the SA casting was handled by the Belfast-based team itself. Even shows like Holby City and Doctors which are filmed out of the BBC studio in Birmingham, their casting office is just north of London so anyone who auditions for those shows has to travel to London. Shows that have Writers' Rooms, the WR will usually be in LA, even if it's filmed in Canada. Ditto the production office and production meetings.
If someone didn't know anything about TV/film and has never worked in the industry, it's understandable to look at the public information and make a superficial assumption "oh X Files is Canada/GoT is Belfast/Holby is Birmingham, that must be where the whole thing is made." That simply isn't the case because TV/film doesn't work like that. It's a shame, and I personally am involved in several campaigns to de-centralise casting, because it's deeply unfair that actors outside of London lack access to so many auditions and opportunities (and it's worse in the US since the distances involved are so much greater).
If Meghan plans to audition for acting roles, or take production meetings (which presumably she will as part of her Netflix deal) then LA is still where most of those auditions and meetings take place. Not to say that she couldn't do things from elsewhere - especially now when so much is happening over Zoom - but being in LA would help.