Immune/ NK cells - Pred threat 27

[LaurenAB94]

@Bambii @Daffodil21 @Eeviee @Everhopeful35 @farfromperfect82 @Eeviee @Everhopeful35 @Hazlet2 @farfromperfect82 @HoldingOn2Hope @Jellystar23 @KtAgs @Lalaifa @LookingforAnswers86 @Marabouchoc @LRL12 @MrsMargot @Naticle @NessyT91 @NessyT91 @NICK7nick7 @rainwillmaketheflowersgrow @Rebecca9876 @Sophfr17 @Tinpo @VenusStarr @Wheresmyrainbow @Whyisthistakingsolong

Hope everyone’s doing ok. I’m feeling a bit crampy today at 4 weeks but trying not to worry... easier said than done!

When did everyone book in their six week scan with dr S? I’m worried about getting time off work at such short notice again. Do you just book it when you’re there for intralipids?

@Tinpo I booked mine when I had my intralipids 😊 just remember it's normal to have some cramps during early pregnancy when baby is implanting. Those first few weeks are the worst but you've got the best doctor behind you.

Thanks @LaurenAB94 - I keep reading that cramping is normal but so hard not to over think everything. I’m just reminding myself that I can’t change the outcome now!

Tinpo, did you get pregnant on ivf?

I got pregnant naturally and had cramps on the day my period was due to start if that helps. I know mine didn’t end well but it got all the way to 8weeks and the cramps at 4 weeks were ok. I think also when I took the progesterone suppositories it made me cramp a little!?!

Does anyone think of conceiving all the time? My reflexologist said that I need to find other things to think about but I thought it was normal to think about it all the time. I just lost one and it’s raw but I want to try ivf even though I’m not sure it will work for us I want to try... I have only done one round but guess I fall pregnant naturally and worry maybe I won’t with ivf but natural isn’t working either:-(

Hi @Unicorn9 - it’s a natural pregnancy and my period would have been due yesterday or today so that’s reassuring.

I know what you mean about thinking about ttc all the time. Whenever I’m trying I pretty much check out of every other aspect of life and can’t focus on anything else! I’m so sorry you’re having a hard time. X

It’s hard after 6 miscarriages and one failed ivf transfer of a euploid embryo, why won’t it just work!?! I am now taking sitagliptin and then hope to go back for FET and start in pred again...

@Unicorn9 it’s just so unfair, and impossible to not let it take over your life. And only those of us in this position can really understand the impact it has. Even now that I’ve had a positive I’m getting upset at family talking about my pregnancy as if there’s going to be a baby at the end of it (had to tell them early as they look after my older child for appointments). I’m so traumatised from previous losses that I can’t even let myself think this will be a success, and am annoyed that they’re being so casual about it and not understanding how horrendously terrifying this is.

I’m not familiar with sitagliptin - what’s that one for? I really hope your next pregnancy is a success ❤️

Those of you who tapered off pred, did you notice a change in how often you need to pee? I used to get up every 2 hours to pee (so at least 4 times a night) then last few days there's been a couple of 4 hour gaps, and last night I only had to get up twice, and the second time wasn't until 6:45 when my husband's alarm went off. I'm not sure I would have woken until my own alarm if mine hadn't gone off.

Really worrying this is a significant loss of symptom. I don't have many symptoms but frequent urination was one of them, particularly at night. It was annoying but I found it reassuring, and now I'm really struggling with the anxiety of it all. I did have a private scan booked for Friday, but I've just moved it to tonight, so I will hopefully have some answers soon either way unless it's just building up to a loss of course.

@Unicorn9 sorry to hear you're having such a hard time. It really is all consuming and takes over your life. My reflexologist said the same. She said I should get some new hobbies, take a course or something, anything to throw my focus into. But that's easier said than done

Tinpo I was the same. I got sent for 6,7,8 week scans and in hindsight I would choose not to look at the scans and just get the reports sent to my consultant for him to say yes it’s ok or no it’s not at least that way I would t have formed an attachment. I dreaded the 6 week scan and then it was fine and the same for 7 week and then I got so positive it was working until it wasn’t... so I so understand the part about everyone assuming it will work. We tell no one now. I missed my brother in laws funeral (he passed at 44 years old surprisingly) because I was pregnant and we still didn’t explain ourselves. With so many losses we never tell anyone anymore. It’s so hard though. It’s meant to be exciting isn’t it, it’s just not anymore... Sitagliptin is a trial drug. So a trial was done by coventry where woman with recurrent miscarriage (average was 5 I think) and when they were given it they had an increased number of stem cells in their uterus which they found to be lower in women with RM. I think those who became pregnant after, none miscarried but it was a trial only of about 40 women I think so they need more funding to research further...

Daffodil21 if it’s any consolation I had no symptoms with my DD. It was a long time ago but all I recall is that I had a metallic taste in my mouth and that was it. Good luck for the scan tonight.

www.tommys.org/research/research-topics/miscarriage-research/can-sitagliptin-help-increase-stem-cells-wombs-women-who-have-suffered-recurrent-miscarriages

Not all participants stayed pregnant. I think 3 miscarried with two being chromosomal issues.

@Daffodil21 one of the main side effects of prednisone is Urinating more it's really common for this to ease off when you reduce your dose x

@LaurenAB94 thank you, that's reassuring, I really hope that's all it is. It's just such a rapid change! I've been having some twinges today and yesterday too. I hate this 😩😩😩

Sorry, that was a really insensitive thing to say on this thread. I hope I didn't upset anyone. I am, of course so grateful to be pregnant, I just wish it was more enjoyable

@Daffodil21 don't worry we all completely understand it's so hard to enjoy it when your worrying throughout.

Just to update - all is ok, and it's a boy 💙

Amazing news @Daffodil21 - and don’t worry, we’re not expected to enjoy every second of pregnancy! It’s always going to be a struggle. How far along are you?

@Unicorn9 I’m so sorry you’ve been through such a hard time and had to keep it from family. That drug sounds promising so I hope it helps you ❤️

@Tinpo I'll be 15 weeks on Thursday. He said he needs to confirm the sex at the next next scan, but he's pretty sure - and showed us why 😂

@Daffodil21 that's lovely news. I've had to move my 12 week scan a week forward as the professor is off or something so I'm having that at 11weeks and then having my final scan and discharge appointment with Dr S at 15weeks instead of 16weeks so really hoping they can tell us what sex our baby is at 15weeks if not it doesn't matter but my husband wants to be there 😊 I'll be anxious to finish treatment with him xx

Daffodil21 and LaurenAB94 what medication were you on this time and anything you did that you think helped keep them?

@LaurenAB94 you might be lucky! He said he needs to confirm at the next scan but it was fairly obvious!!

@Unicorn9 I'm just on cyclogest and pred (although tapering off pred now). I firmly believe it's the pred that's got us this far. I've had no tests to confirm though, so it is just speculation x

Daffodil21 when did you start the pred? I wonder when you start it for a natural pregnancy vs ivf. I think the latter I was told at FET...

Do anyone have intralipids as well?

@Unicorn9 I started on 5mg twice per day from 2dpo, then I upped to the full dose when I got my bfp. I just have to stress though that it was not under medical supervision, it was purely based on what I had read in 'is your body baby ready' so it probably wasn't the most responsible way to take it

Hi all, haven't been on this thread for months now but as things are starting to move again for me I thought I would pop back on and say hello! I got so fed up with the waiting game that i just couldn't bare talking about this anymore!! Congratulations to those who have had good news, after 6 losses i am praying I will follow in your footsteps. I'm doing a frozen embryo transfer in the next couple of weeks, have had my Prostap injection and waiting for the next bleed so I can begin all my meds....Progynova, cyclogest, lubion, hydroxy and this time Dr S wants me to start on 25mg Pred aswell as fragmin and of course intralipids and every other bloomin supplement. Have to say I am a little apprehensive taking all of these medicines?! Trying not to think about it too much but ive started having nightmares and not sleeping well at all, guess I'm just freaking myself out a bit. I cant think about the cost of all of this or I really will freak out!! I dunno, just feeling a bit down just now. I used to be so full of hope but im just terrified now....also is it just me or is everyone and their granny falling pregnant at the moment?! Everytime I go on social media or get newsflash on my phone its a pregnancy announcement aah! (Sorry for my whining to you girls that have wonderful news, I'm just jealous lol!). Sorry for my moaning, there's not really anyone else I can talk to about this and I know you guys know how I feel xxx

@Luckyducky2 good luck with your transfer, try not to worry too much about the meds Dr S wouldn't recommend them if he didn't think they were safe or that they'd help. I understand how hard it is for you to watch everyone else getting pregnant around you I just hope soon it's your turn. Take care and look after yourself x

Good luck @Luckyducky2 - I hope this is your rainbow! I know what you mean about pregnancy announcements. Even during my last pregnancy, when things looked like they were going ok (up to 20 weeks when I lost him) I still found announcements like a punch in the stomach. I find it so upsetting that other people get pregnant, get to 12 weeks and know they will get a baby, whereas for me there’s no ‘safe’ point and will never have that pregnancy excitement or innocence again. With my first loss I was pregnant at the same time as Meghan and Harry, and when I went into the bereavement suite to deliver her there was a little tea making area in the room, and the only mug was one with Harry and Meghan on it 😐 and now they’re pregnant again at the same time as me so it’s an extra reminder. (Obviously it’s great she’s been so open about her loss too - I’m not a Meghan hater, just sad that it’s such a stark reminder)

Anyway sorry for the rant. Don’t worry about all the medication - you’re in the best hands with Dr S. Every time I take a tablet (or stick a cyclogest up my bum 😶) I feel like I’m doing something good for my baby and giving them the best chance.