Well, will see what my consultant has to say when I see him week after next, but I’ve read some really interesting stuff from a fertility clinic in NYC that specialises in treating women with diminished ovarian reserve (DOR) and premature ovarian ageing (POA), and they say they treat a quite a lot of slim women who were given a lean PCOS diagnosis when younger, and who then come to the clinic in their 30s with POA. They call it ‘burning out PCOS’ - the ovaries got used to being in a hyper-androgenic state (too much testosterone) when younger and burned through eggs at a faster rate, and then presenting with a hypo-androgenic state (too little testosterone) when older.
It seems to be a particular genetic mutation, and it all pretty much seems to fit exactly with what’s happened to me. There’s one study that even says they start to see patients presenting with DOR at around 32/33. I am 33! When I presented as PCOS I had acne, and my testosterone was in the middle of normal range - now I have no acne, and my testosterone was barely detectable in my recent bloods.
So if I have this shitty gene, I’ll know it was just my lot, and the tests weren’t wrong, but we’ll know what we’re dealing with. And apparently androgen supplementation can make a significant difference (am already on DHEA which is something) Oh, and this gene also apparently guarantees autoimmunity which makes implantation less likely and the risk of miscarriage much higher, without aggressive immune treatment. Brilliant.
See what the Dr says. It might not be this, but it certainly seems the most logical explanation for my mysterious un-polycystic-ing and disappearance of all my eggs...