Assisted conception after recurrent miscarriage

[duggs1976]

Hey super ovulators and those struggling with infertility after miscarriage this is where we are! Come on over ...

Thanks everyone for your kind wishes.

Sue I didn't take dhea. V interesting re SO. I guess this means that you also fell pg at the first natural attempt after SO.

belly how did your scan go yesterday?

abney yes it was the first month of trying naturally after being on SO.

Welcome back Pebbles did you have a lovely hol? Good luck with the humira tomorrow.

Buzzy sorry that you are feeling 'normal'. Symptom spotting is so hard isn't it - totally messes with your head. Sending you positive vibes.

Thanks for asking about the scan, Sue I had 7 follicles although they all seemed to be of varying sizes. Am taking the trigger injection tonight for egg collection on Tues. Womb lining looking good due to oestrogen patch on my bum! Haven't dr googled too much on the follicle sizes as I don't think it will help with general mentalling. Dr N thinks we should be able to get something - which is as good as can be hoped at my age, I think. Just going to take it a day at a time from here on in. Finishing stimms drugs today before getting going with the pred, progesterone injections and clexane on Weds. Will keep you posted.

belly glad the scan went well. Can you remember the follicle sizes you had? It would be interesting for me to know how someone with the same amh and age as me has responded to the different drugs. I might need to think about another go on the same as you so the more info the better so that I can plead my case!

Forgot to ask but were you on the long or short protocol? Did you take dhea? I am seriously considering going to the zw clinic now seeing as we had our cycle cancelled so we have the egg collection money earmarked already. We have both had all the blood tests already so it would just be the initial consultation and the cost of the drugs again. belly would you mind telling me the costs involved already for you as I will need to speak to DH. He won't be happy with me!
Annoyed that I didn't go there in the first place as I will have to wait a clear cycle before I could start treatment again.
Did you also have an up to date Fsh test or did they just go on your amh?

7 follicles is great by the way so I would be really pleased if I were you!!!

Sue I'll pm you the info tomorrow, but am on a long protocol x

Sue I'll pm you the info tomorrow, but am on a long protocol x

Thanks Belly

Sue have pm'd you.

Do you know your fsh, Sue? Mine was 9.7 the last time I had it done, at the point where my AMH was 1.14. (My AMH went from 1.5, to 2.1 and then 1.14, over the 6 months I took DHEA, at which latter point I conceived, so DHEA did not increase my AMH overall, even though I got pregnant.)

Did anyone read this?
www.dailymail.co.uk/femail/article-2333181/My-miracle-baby-19-miscarriages-Mother-Jo-Short-Newport-Wales-ITV-Daybreak-endometriosis-surgery.html

I think that is one seriously strong woman. I do not know how she has been able to cope with that many miscarriages. I would of been a nervous wreak in her shoes.

Just shows you perseverance pays off! Call me desperate but I have just booked an appointment with the Zita West clinic after hearing the different response BellyD has had to me. I am hoping my continued quest will finally pay off.

Brown I havent had my FSH tested for a year - it was 6.9 in April 2012. Most of the clinics don't look at FSH now so I haven't bothered as it will only make me panic more! I was told that FSH measures the hormones that tells you if you are menopausal or not, you can apparently have low AMH and a normal FSH and therefore not be menopausal. Not sure how that helps the situation though.

I am having all the treatments anyway now so including acupuncture to lower FSH so not sure what else I can do.

I am going to hold off on DHEA until I speak to Dr N at Zita West as I don't think its the egg quality I have the issue with, more the quantity (which cant be changed). I could be wrong though!!! It's only since the medical termination last October that I have had problems with my cycles being all over the place, before that I was conceiving 3-4 times a year. I still think that the Hydroxy helped my immune problem and thats why I got to 22 weeks with Scarlet. If she didnt have the kidney defect I would have a baby by now as the miscarriage problem was sorted for that pregnancy. I just need to get pregnant to see if it works again.

A mum at my DDs school has had at least 19 miscarriages after her 7 year old daughter. She ha given up now as is 46. I think it is more common than we realise. I just assume that people with one or more kids dont experience multiple miscarriages like the rest of us.

Thanks Belly, it was very quite.
Well done on the seven follies and good luck for the egg collection, keep us posted.

Did you get your results today Mel? Also quick question re the humira, am I right in thinking it is in the system for about 6mths? Did you go and see Mr S after taking all your injections?

When is your appointment Sue?

Wow 19 miscarriages just doesn't bare thinking about!!

Hi no results as yet!
Saw mr s after the second injection for retest then I think Louise just emailed me the result and sent more humira if I remember correctly but as I needed 2 more they don't retest after those.
Yes it stays 6-9 months so hence why we are on the train again so soon so to speak ;)
X

I am on my second lot of humira as well and not sure if going back to see Mr S. Will see what Care say when I go for appointment with them and go from there.x

He won't retest as that's the maximum so doesn't see the point but I wish I knew what mine were as that could of impacted on miscarriage I guess if not on a enough medication for tnf alpha? I wish my restrevatol would hurry up that helps to lower it!
What did your level drop to after 2 i can't remember. It will be interesting what care says x

Hi ladies ... Reading everyone's posts but keeping my head down a bit at the mo, I'm sure you can understand. pebbles glad you had a good holiday, and are all fired up now for your IVF with Care.

abney So pleased to hear about little Lewis, I love a happy ending especially after you'd been through so much!

sue Lots of luck for your switch to ZW .. I was talking to a lady who's at ZW when I was having my last lot of intralipids at INS 2 weeks ago, she said they were really good.

belly Good luck for your EC today!

buzzy Completely understand the mentalling over the symptoms, it's a real PITA that they come and go, doesn't give you any reassurance at all at a time you really need it. Fingers crossed for your next scan!

Well we're still in limboland here, hCG is still rising but nowhere near doubling and in fact doubling rates are slowing. Because hCG is still rising, Penny says we can't give up med support yet, so I'm still taking everything except Clexane, which she said to stop as there's little point continuing with it. Test yesterday showed hCG at 849.9, progesterone bizarrely jumped back up to 31.09 (no idea why, still taking the same supplements). Test on Friday, which was 72 hours before, my hCG was 561.8 and my progesterone had dropped to 15.64. No clue what's going on, why my progesterone has jumped back up again. Doubling time to my test last Friday was 73.9 hours, to the test yesterday it had slowed even further to 122.2 hours, so this is clearly a failing pregnancy.

Penny has asked me to have yet another test tomorrow (48 hours after the last one) and also a scan to see if there's a sac, as she needs to rule out an ectopic pregnancy. That's the last thing I need!! Either way it isn't going to be a good scan, that's impossible, but I'm now praying it's not ectopic.

/waves to everyone

Pebbles appointment is 18th July but it looks like they don't start treatment until 3-4 months after that which is a pain. Worried my AMH will go even lower.

Ari I really feel for you as you want the uncertainty to be over either way. Don't you normally have a lot of pain with an eptopic? At least a scan will give you peace of mind - I would go sooner rather than later. How many weeks should you be by now? Where do you get the HCG tests done - could they be wrong???

Buzzy have you had any more symptoms?

Belly what time is your egg collection today? Hope it all goes well and they gets lots of lovely eggs!!

Forgot to ask - when does the HCG shot leave your system? I took it last wed eve so am hoping it will be out of my system in the next few days. Not due to test until a week on fri but getting impatient already. Started the preds again on saturday and then started to feel really depressed by Sunday morning - I hate taking steroids so think if I dont get a BFP this month I will only take them from a BFP (if I ever get another one).

ari, I don't want to give you false hope, but is it not at all possible that originally there was more than one embryo implanted, and now there's just one?
Sue, not sure about the hcg but re. the steroids, on the cycle I got pregnant, I took the pred only from 4dpo, and only 10mg. That was much more tolerable; no side effects until I went up to 25mg on BFP. Mr S seemed happy with that when I told him.

sue Apparently you don't always get pain with an ectopic, unless it bursts (or is imminently going to burst), according to the reading around I've just been doing. I'm technically 6w3d at the moment, and I get my hCG tests done at a pathology lab in Guildford that's aligned with the Royal Surrey Hospital, so I'd presume they're not wrong.

Not sure how long the hCG shot takes to leave your system but I think duggs knows as she just went through this.

brown Well that's possible, except that my hCG levels are so very low they are bad for a singleton, let alone for two. I know if you have a reasonable hCG level that then takes a dip and then goes up again can be indicative of twins where one dies (hence the dip) and the other keeps growing (where it goes up again). But what I'm seeing is very low hCG that is slowing it's rate of increase.

Actually I just started a little bleeding in the past half-hour (only when I wipe at the moment) so that's completely in line with an imminent miscarriage. Penny has said to do the blood test tomorrow as we'd arranged, and then see from that result whether to bother with a scan on Thu.

sue Penny has her ladies taking 10mg pred a month before egg transfer, and believes that that is enough to suppress most NK cell issues. So as brown says, perhaps 10mg from ovulation would be ok?

I think it went down to 33 Mel so is getting there! I understand though that even if your levels don't drop enough the humira is still working in your system.

Sorry to hear you are still stuck in limbo Ari and hope it doesn't turn out as ectopic. A close friend of mine had an ectopic and she bled heavily for quite a while. I hope the time doesn't drag to slowly for you, it's so hard to think of anything else!

Wow that seems a long time to wait Sue, is that because they are so busy or they want to monitor you first?
Re the hcg I think for me I poas about 11 days later and it was still showing feintly.