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Infertility

Our Infertility Support forum is a space to connect with others in the same position, discuss causes, treatment and IVF, and share infertility stories of hope and success.

Assisted conception after recurrent miscarriage

1000 replies

duggs1976 · 22/05/2013 19:49

Hey super ovulators and those struggling with infertility after miscarriage this is where we are! Come on over ...

OP posts:
brownstag · 28/05/2013 10:20

Ari, is it time to test yet?

Arianrhod · 28/05/2013 12:24

sue Will answer your IL question as soon as I get home as one-handed on phone at mo with ILs in other arm.

Thanks for asking brown .. will answer properly also when I get home but not great news - v faint FRER positive. At 12 days past a 5-day blast transfer that ain't good. Here we flippin' go again.

Arianrhod · 28/05/2013 12:43

mel Haven't forgotten you too, will PM you when I get back. I got our DQa test done via Mr S; Dr G does them too and poss other places?

brownstag · 28/05/2013 13:51

Isn't that good, Ari? What difference does the 5 days make? Sorry, being thick here. Ordinarily that would be fine, wouldn't it?

brownstag · 28/05/2013 13:57

Of course, I get it now; there isn't a wait for the fertilised egg to travel down the fallopian tube, so really you're just waiting for implantation and for hcg to rise ... but you haven't started your period, so there's still hope. When do you/did you have your blood test?

Arianrhod · 28/05/2013 16:22

sue and duggs ... ILs seem to be administered in the same dose for all clinics. My Serum prescription says 100ml 20% which INS then dilute with 500ml saline. Serum tend to do it without saline which is why their prescriptions don't specify the saline but everywhere else, including New Life, mix with saline solution, and that's what INS recommend so that's what I have. INS will provide the intralipids/saline if you have a prescription for them, and the total cost of providing the ILs and administering them is £103. I know, I just had it done this morning. I have to say my own experience with them is excellent - I've had them twice there and both times they got the drip into my arm with no problems at all and virtually no pain, which is a first for me. NL hurt the hell out of me the two times I had them done there, the first time I almost passed out because they put it in my hand and they had real problems getting the cannula in. (making me wince remembering!) Also INS were great today, I rang at half-nine and asked if there was any chance they could fit me in for an 'emergency' IL and they said just come along, we'll fit you in when you get here. And they did. They keep the ILs in stock; there were two other IVF ladies there from different clinics having them done while I was there.

Just my experience, you understand.

mel Best of luck for your Serum trip. If you're going to go to the hotel by taxi from the airport then you don't need my bus tips on where to get the ticket and bus :) Hand luggage will be fine - if you find you have too many toiletry-freebies from Yaia to take (some are too big millilitre-wise for hand luggage) you can just give them to the staff at Serum if you like, I don't know what they do with them but I know other ladies do this. If you want bottles of water, get them from the little cafe at the entrance of the Yaia clinic, they're only 50 cents! Take something to eat (and your bottle of water) with you for after the op; they want you to eat and drink something but they don't provide it. They're not that fussed though - I think I had something like half a packet of mini gingerbread biscuits and some water, and they were happy with that :)

You have Agate's map, yes? That will show you how to get to Serum from the Alex - don't worry that the side streets all look really run down and the building Serum is in looks very unprepossessing; it's much nicer on the inside. And when you try to push the front door of Serum open you can't, it's on a buzzer lock; the girls on reception will buzz the door open when they see you pushing it! :) Lots of luck, and let us know how you get on!

Yes brown that's exactly the issue. The embryos were already 5 day blasts - ie, just about to hatch - when they were transferred, so implantation should have been within the next few days; they don't need to travel down the fallopian tubes etc. So getting a faint FRER line this morning - bear in mind that FRER are sensitive to 12.5miu - is pretty rubbish; I had 3 'perfect' blasts, if even only one of them had implanted properly within the right sort of time frame I should have a hell of a lot more hCG in my system than 12miu! A faint line means ... well, I don't know what it means, but of my 6 failed pregnancies, the only ones that got further than 5 weeks I had a strong FRER at 12dpo. I would guess I'm the equivalent of 17dpo (egg collection plus 5 days getting to blastocyst and egg transfer plus 12 days to my test this morning). By anyone's standards a faint line cannot be a good thing.

Penny has told me to do 3 hCG 'rescue' shots 2 days apart - so, one today, one Thu, one Sat, and then see. She told me to get my hCG measured Thu before my next shot (and presumably can tell me how much to subtract for the hCG already in my system from the 'rescue' shot), but of course I then can't get the 48-hour follow-up one done on Saturday. My GP's lab will only turn these tests around in 48 hours, which is no use, so I'm having to go to a private path lab in Guildford to get them done (more kerching!) and they're not open Saturdays (as I believe nowhere is, actually).

Basically I'm not going to know for ... well, who knows? I don't believe my period WILL start while I'm taking oestrogen and progesterone supplements - I think I would only start bleeding if I stop these. So even that isn't an indicator.

I HATE this inconclusiveness - it's what did my head in before, and here we are all over again. I could almost take a clean BFN - at least that way we know it hasn't worked at all. But this faint line - it's an 'almost pregnant'. Is it implantation problems? Shouldn't be, with a 'clean' rejuvenated uterus after the hysto/implantation cuts. NK cell issues? Who knows!

Mel3062 · 28/05/2013 16:36

Thanks ari
Not getting taxi now so maybe the bus or metro. I don't know what to pack!! Did you pack a towel? X hope it works out for you

Arianrhod · 28/05/2013 16:53

Towel, as in, bath type towel? Or do you mean sanitary towel? I did take my own sanitary towels (one of those 'night' ones with wings, very thin but very good absorbency) and used those because I don't like the bulky ones and I've used these successfully in miscarriages before.

Both bus and metro are easy, although metro gives you a 15-20 min walk whereas bus stop is about 4 mins walk from the Alex. If you catch the bus, check the bus departure screen in the baggage reclaim hall (about halfway-ish down the hall, they're mounted up hanging from the ceiling sort of affair between the reclaim belts). Then go out of door 3 from the arrivals hall (walk down the hall, the door entrance/exit numbers are over the doors) and turn right, keep walking until you see the X95 bus stop. There's a ticket booth almost exactly beside it to the right, just ask for one (or two if DH is with you) ticket which will be ?5 each (they prefer exact money). When you get on the bus ask the driver for 'Platia Mavili', he will then let you know when you get there to get off. From memory when you get off the bus, turn right and walk for about 4-5 mins, you'll see the sign for the Alex up a side street to your left. I was doing this at 5am couple of weeks ago and getting quite frustrated that I couldn't find it, I just hadn't walked quite far enough before getting to the side street!

Packing-wise I think it's quite warm over there, so nothing heavy. Anything else you need to know?

Mel3062 · 28/05/2013 17:09

That's fantastic thanks ari. Abit daunting the first time! Yes I ment bath towel! Packed loads of sanitary wear! Directions from Alex to serum would be fab if you can x

Arianrhod · 28/05/2013 17:35

Bath towel, nope, you won't need one. :)

Ok, looking at my map ..

  • turn left as you come out of the revolving doors of the Alex, walk to the end of the little side road the Alex is in and turn left onto the main road (I think the hotel Athinais is on the corner here, by the way - there's a big sign advertising an 8am to 11pm cafe in the Athinais, if I remember correctly).
  • walk along the main road (Vassilissis Sofias) until you get to a pedestrian crossing just past a little kiosk (sells sweets etc), cross over both halves of the main road - they have 'green men' for crossing.
  • I think you'll turn right down possibly the first right after that - named Pirri in English I think - if I remember it was an odd sort of affair, there are taxis parked in this road and on the other side (before you turn) I think some kind of outdoor cafe/seating area. Head down this side street.
  • crossing over to the other side of the road you'll take a left down Evinou - there's a cafe on the corner at the end I think, or just after the end of the road. The road sign for Evinou, if I remember, is on the left-hand side of the road as you face down it, is half-way up the wall and hanging at an angle when I saw it!
  • walk down here, Serum is on the right-hand side and recessed in off the road with a 2-car 'car park' in front; the doors are obscured glass. Serum's name is on the right-hand side of the building as you look at it.

My memory is pretty rubbish, but I think that's fairly accurate. Print out and take Agate's map with you!

Arianrhod · 28/05/2013 17:36

whoops, I meant to say, after you crossed the main road on the pedestrian crossing turn left!

buzzybee123 · 28/05/2013 18:07

ari whispering congrats :) when is OTD

duggs1976 · 28/05/2013 18:32

Ok ari but it doesn't mean all 3 implanted so some HCG must be something ? Quick Q for you- is this with your partners sperm? I know donated eggs but still his sperm?

OP posts:
Mel3062 · 28/05/2013 19:42

Thanks ari you are a star!! Fingers crossed for you x

Arianrhod · 28/05/2013 20:05

buzzy OTD was today hence why I'm worried at such a faint line.

duggs yes with OH's sperm, so we still have a 50% DQa match problem.

Arianrhod · 28/05/2013 20:07

And thanks mel - if there's anything else I can help with just shout. Best of luck for your trip!

Yes duggs something must be trying to implant but so late on it should have implanted by now if it was going to. I'm not completely giving up, I'm doing the rescue shots, but I have very little hope.

Mel3062 · 28/05/2013 21:01

Thanks ladies I'm sure youl all join me for hand holding!! Ari I so hope that lines stronger on Friday when I get home!x

duggs1976 · 28/05/2013 22:11

Trying to understand if the line doesn't get stronger does that mean if you tried a donated embryo u will have the chance of a "normal" person?

OP posts:
Arianrhod · 28/05/2013 22:17

Thanks mel but I can't do any more tests as I've done an hCG rescue shot, which would mess with the test. And another due Thurs, with the last on Sat. I'm having bloods done Thu before the Thu shot and again Mon (couldn't do 48 hours apart as I couldn't find anywhere open on Sat, so will have to work out over 4 days rather than 2) - but Penny will have to work out how much of those results is down to the hCG shot still left in my system and subtract it from my bloods result accordingly, to see if anything has actually changed.

Arianrhod · 28/05/2013 22:21

duggs If we'd used donor sperm as well as donor egg then I would presumably have had the same chance as a 'normal' person, yes. But I didn't want to do that, I wanted this to be OH's.

buzzybee123 · 29/05/2013 00:17

ari your protocol sounds complicated, is this OTD as in the clinics one which is normally longer than the 2 weeks after EC??

buzzybee123 · 29/05/2013 00:18

oops posted too soon, a line is a line though, fingers crossed for you,

hello to everyone else

suemays · 29/05/2013 07:58

ari I agree a line is a line. Maybe its just a slow grower? How about if its a multiple pregnancy, would the line be lighter? Have you done a digi test to see what that says?
Th

suemays · 29/05/2013 08:06

Thinking of you and hope it works out. It's amazing you are still on here offering advice and help as I should imagine you are in emotional turmoil at the mo. thanks for the info on INS I will be using them if I get that far.

buzzy did you have any more pink spotting?

breezy and anyone else starting ivf, I forgot to say that the clinic have given me a pen which you put the needle in to do the injections so it doesn't hurt. Much easier than trying to stab yourself and then push the plunger in as it has a spring loaded button to push. I was told the lister in Chelsea doesn't offer them so ask!

mel virtual handholding here so good luck.

duggs any promis signs from you yet?

I am going in to have my first follicle scan this afternoon so we should see if I am responding to the drugs.

suemays · 29/05/2013 08:06

duggs meant to say promising signs from you yet?

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