I say Yes. Mainly because single sex education creates such confident, articulate, ambitious young women.
My dd16 goes to a state comprehensive girls school which is massively oversubscribed, gets great results and is definitely not a “bitchfest”. I asked dd to count how many friends she might “need” to invite if she had a 16th birthday meal, and she listed 17 people who she counts as excellent friends. She is not a popular girl - it has just turned out to be a really great place to socialise and learn. Also the school does an impressive job making sure the girls are ready to launch into a world that is still, in so many ways, dominated by men. They grow up with an attitude that they can do and be anything they wish.
This is in large part due to the female-led SLT. There is an active focus on making sure women are kept front and centre in the more flexible lower school curriculum - eg in art and English they study the work of contemporary women working in the arts and literature, whereas in history or science they might study secondary sources authored by women. It’s quite subtle but the point is made - a girl has published this research; this could be you.
There are not many options for state comprehensive girls education where we live but this has been a transformational educational experience for dd.
Interestingly also the problem of trans people hasn’t really come up at all. There are girls who are out as lesbians but I’m not aware of a single girl leaving because she is claiming to be a boy. Why would you need to define yourself as male, when girls can do anything and “be” however they want? If you want to be a woman with masculine characteristics, then be that. Problem solved.
And furthermore there is no school-sponsored LGTBQIA+ club, like there is at the local mixed comp. So none of this navel-gazing.
So for girls - it’s a resounding YES from me.