Ireland halting the use of the AstraZeneca vaccine

[Kaylasmum49]

This just came up on my phone. I had the AZ vaccine 10 days ago. I'm concerned about the news of blood clotting issues.

www.google.co.uk/amp/s/www.dailymail.co.uk/news/article-9366963/amp/Coronavirus-Pfizers-Covid-vaccine-linked-blood-clots-AstraZenecas-UK.html

Very interesting article I dug up

I found some, thank you @CuriousaboutSamphire !

And thank you to everyone who have been able to back their arguments with actual facts, data, information unlike the usual anti vaxxers bullshit.

Throughly enjoyed this thread

Sorry @FaithfullyYours I meant to come back with a link or two, but got sidetracked by a house purchase question

In retrospect halting the vaccinations over this is going to be just another stumble in the EU rollout that caused unnecessary cases. Hopefully, the EMA will tell everyone to get on with it soon.

this was in that article I linked to - thrombo events in the US linked to Pfizer & Moderna:

There are >50 cases of idiopatic thrombocytopenia in US after Pfizer or Moderna. All after dose 1. We didn’t suspend vaccination for that. We learned how to treat them and no one has died after case 1.
onlinelibrary.wiley.com/doi/10.1002/ajh.26132?af=R

TLDR: at least 3 of the available Covid vaccines have the potential to be involved in abnormal blood clotting - probably due to the antibodies to the SARS-NCOV-2 spike protein that they stimulate production of - which is why this is also a problem, in fact more so, for many people who actually get Covid - from similar antibodies they make to the SARS-NCOV-2 virus spike protein as a result of getting the disease but in a more uncontrolled fashion.

Thrombocytopaenia is low platelets leading to unusual bleeding - the complete opposite of clots. But as mentioned in the article - incidence is extremely low and it can be successfully treated so long as it is identified.

I think one hypothesis is that the thrombocytopaenia at or around the vaccination site causes blood pooling and then clots at other sites in succeptible individuals - hence unusual clot locations - can't remember the name of the condition at the moment.

More sources on Pfizer /AZ:

As of 9th March, the UK has seen 13 clotting instances with AZ and 15 with Pfizer, resulting in 2 deaths (1 from each vaccine). That's from roughly 20M doses (with a 50/50 split of vaccine type).

assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/968414/COVID-19_AstraZeneca_Vaccine_Analysis_Print.pdf (page 55)

assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/968413/COVID-19_mRNA_Pfizer-BioNTech_Vaccine_Analysis_Print__2.pdf (page 52)

France has found a variant that doesn't show up on test (How did they find it?)

If that was running around Europe it would possibly be the cause of any unusual symptoms or deaths. Maybe?

Immune thrombocytopenic purpura causing disseminated intravascular coagulation was one proposed (only) mechanism for the cases in Europe I read about today - I think this is the line of investigatin in Germany - also seen in Covid patients of course.

@Truelymadlydeeplysomeonesmum

France has found a variant that doesn't show up on test (How did they find it?)

If that was running around Europe it would possibly be the cause of any unusual symptoms or deaths. Maybe?

Finland also had a bunch of cases a while back of a special variant that couldn't be picked up by PCR tests. (Also no idea how they knew!)

I think they mean no tests can show varient. Only genome testing the pcr results show what varient.
France I read has high amount of Brazilian and South African and well as UK varient .
Denmark is very good at genome testing think lots of European countries are not.
It wouldn't surprise me if there's new mutations.

@3asAbird

I think they mean no tests can show varient. Only genome testing the pcr results show what varient. France I read has high amount of Brazilian and South African and well as UK varient . Denmark is very good at genome testing think lots of European countries are not. It wouldn't surprise me if there's new mutations.

But why would they test negative PCR test? I have so many questions about this.

In our bit of France it is now 70% British variant and 5% South African / Brazilian. The rest is "classic". The new one that doesn't show on PCR seems to be called the Brittany variant.

Don't they just sequence all infections from hospital blood samples of all patients that are hospitalised for covid (plus some random sampling in the community I imagine) - I guess they have a wider range of PCR probes to different parts of the whole virus to pull them out - not just the particular region the PCR antigen test uses?

No they only genome postive covid 19 tests from pcr only.
Its reason why all the UK surge testing for odd and new varients is pcr not lateral flow.
No idea how much France do.
Thered actually 2 different types of Brazilian varient too.
I guess Brittany is like Bristol or Liverpool varient with has 484k in its sequencing pattern which is less effective with vaccines.
In the UK we usually randomly genome sequence 10% postives samples not sure if we increased that to 15 or just on areas of concern

The original "Kent" variant was picked up because it only reacted (if that's the right word) with two of the pcr probes not 3 (someone please correct me if I've got that wrong).

Do we know what was the treatment applied in the US for these cases?

There are >50 cases of trombocytopenia in US after Moderna/Pfizer vaccination
US response was not stop vaccinating, but immediately develop treatment model. After case 1, everyone recovered. This is what EU should do

From the comments on the article linked before

blogs.sciencemag.org/pipeline/archives/2021/03/16/what-is-going-on-with-the-astrazeneca-oxford-vaccine#comment-340455

www.dailymail.co.uk/health/article-9416171/AstraZenecas-vaccine-trigger-rare-immune-response-leads-clots-people.html