I think uptake I running at about 85%, which is great but I hope we can improve it further.
We are really lacking in some of information that would help us appraise the situation fully.
We don’t know with much degree of certainty what the actual chances of infection with SA variant /B1351 are for those vaccinated with AZ/Pfizer/Moderna or previously infected, we don’t know the chance of serious illness in these scenarios, we don’t know how this would differ by age etc. We don’t really know how widespread this strain is in the UK, or the B117 + E484K strain. We aren’t clear on the transmissibility characteristics of B1351 either. We also don’t know what other variants could be popping up. A lot of unknowns!
However what data we do have definitely point to there being a problem. Reinfections are happening with B1351 and all vaccines appear to be losing some efficacy against it, AZ perhaps quite significantly. This does imply, unfortunately, a longer exit period than would have been anticipated without the emergence of these variants. I think that means it’s reasonable to entertain different scenarios for how it could play out, best and worst. No one can guarantee either.
If I were strategising this I am now wondering if, after vaccinating broadly as we are doing, which I do agree is the right strategy now with high infections and immediate risk to life, I’d next be considering targeting the most efficacious vaccine boosters available to the spreaders first - if only we could know who they are. I know a lot of these vaccine strategy pieces were shared here a while ago.
I’m feeling positive in the sense that smart people are keenly aware of the problem and they are working on it.