Immune/NK cells pred thread #32

[VenusStarr]

Hi everyone. The last thread is filling up. Have tried to tag everyone who posted on the last few pages, but feel free to join / tag anyone I missed.

@Gizmo1983
@fleur89
@Sunflower360
@MotherOfShihTzus
@lozzmax
@HopefulH
@kea1990
@Sprinkleofbabydust
@Newbeginnings22023
@star2022
@RumandSpinach
@Ems123456789
@MamaW05

Love to all ❤️

@Rainbowsunshine81 its a bit strange i honestly was waiting to fall even deeper into depression after my chemical, it’s been so strange in that i feel so much better. It’s like there’s been a chemical shift in my brain and I’m back to my old self it’s a bit worrying really but I’m just enjoying it while it lasts. I’ve been in such a bad place for almost a year. Maybe it’s for to having the ivf coming up but I know there are certainly no guarantees this is going to work either. Maybe it’s the no pressure this month having to dtd at the right time as both me and hubby were knackered lol.
@Rainbowsunshine81 so what is your next step now im quite a newbie to all this so don’t understand the different medications and stages x

@Gizmo1983 we fly to Cyprus on Thursday for the frozen embryo transfer, last nafarelin spray tomorrow, continue on the progynova and aspirin. Start the Cyclogest tomorrow, my husband affectionately calls the bum bullets 😁
I had the noristerone which makes you have a bleed, on them for 10 days, then a bleed, have the nafarelin spray which quietens down your ovaries, then a scan to check the ovaries are not active, also to see if the lining is thin enough. Then the progynova to start to thicken the lining, alongside aspirin which is supposed to help increase blood flow to the womb, then the Cyclogest alongside these to also help thicken the womb lining. Xx

@Gizmo1983 thanks, appreciate that, the tww is the worst but not sure it gets any better between that and the 12 week point (not that I've ever got past 2ww as yet), never ending rollercoaster! Glad to hear you're feeling better, I had a 2 month break earlier this year (enforced one due to needing a Hysteroscopy) and I have to say I felt the same. Even though initially I was frustrated by the delay, I found not thinking about the IVF a real help mentally, like a load had been lifted. It was actually quite nice thinking about anything but the IVF, looking forward to feeling like that again I have to say.

@Gizmo1983 tell a lie...I did get past 2ww last summer once with a chemical but I lost that week 5... so the joy lasted all of 1 day with the pregnancy test result as I was spotting and pre empted it would not end well and of course it didn't. As I said, a rollercoaster!

@Sunflower360 i was exactly the same with my chemical. I got my positive on the Friday but knew by the Saturday night and defo the Sunday morning it was over. I suppose I was just grateful I didn’t get to 15 weeks for it all to go wrong again that was awful. How are you doing its such a roller coaster isn’t it 😢.
@Rainbowsunshine81 oh wow so you are really close to transfer and you get to go to sunny Cyprus as well win win 😊. I’ve been given norethisterine to start taking on the 20th of this month. I have one last chance to get naturally pregnant before the IVF I’m not even ovulation testing it hasn’t happened in the last year so doubt it will happen this month. We are both happy to go for ivf now xxx
love to all 🥰

@Gizmo1983 feels like it's taken some time to get to this point again. Only going for two nights this time, sort of wish we were going for a little longer, but then think will be nice to be at home.
That's good that you are both happy to start ivf now ❤️ ❤️ xxx

@Sunflower360 thinking of you. Hope you're ok and that OTD has been ok.

I have a hysteroscopy today, typically my period has just showed up but fortunately they've said we can go ahead. I'm not in a good place mentally. I tried to soldier on after the last loss and I think it's finally caught up with me, I keep crying and I feel like there's an elephant on my chest. Because I had a successful pregnancy with Dr. S, I have felt like I couldn't grieve the three losses we've had in the past year because it felt selfish and that I should count my blessings (which I do daily). It feels like it's found a way of coming out and I'm not sure how to handle it. If anyone has had any good therapy to process it all, I'd love to hear what worked. I know this isn't anxiety, I already get treated for that from the losses I had before my daughter, this feels like some sort of delayed grief or maybe trauma. Not sure. Any help appreciated.

PS, I hope you don't mind me posting, I feel like a bit of a fraud since I have a child and I am conscious of how that might make others feel x

@lozzmax thank you, got my beta results and it is a positive. Very cautiously happy as I'm conscious there is still a way to go. Been advised Prednisolone would potentially stop at the 6/7 week point too after a scan so if it all goes ok up to that point I am a bit nervous about that but I suppose it would have to stop at some point as Prednisolone in itself has risks with long term use.

After a natural chemical, 4 egg collections and 3 FETs (including this one) its hard to get properly excited until you get to the 12 week point, so will be cautious for now.

I'm sorry you are feeling that way, and don't feel bad at all. IVF is such a draining process, and I think only those that have gone through it or know someone close to them who has gone through it, and has been invested in the emotions of it with them, can fully understand what it entails. I genuinely feel whatever happens, I'll always feel this IVF/fertility journey has had an effect on me as a person, its hard for it not to I think

That's wonderful news @Sunflower360. I'm really delighted for you! ❤️❤️❤️ I have everything crossed for you xx

@Sunflower360 that's fabulous news ❤️

@lozzmax @Rainbowsunshine81 thanks both!

@Sunflower360 That’s wonderful news! Keeping everything crossed for you xx

@Sunflower360 ❤️ 😘

@Sunflower360 that is such wonderful news I am so so happy for you. Gentle hugs and got everything crossed I know you’ll be nervous ❤️.
@lozzmax how did the hysteroscopy go fingers crossed all was well xxx
@Rainbowsunshine81 are you all ready for Cyprus got everything crossed it all goes well xxx
@VenusStarr how are you doing sweet?

@Gizmo1983 pretty much, only taking hand luggage and taking as least as possible. Feeling quite apprehensive about it. Thank you very much 🙂 xxx

@Rainbowsunshine81 totally understandable you’re apprehensive. Just take it one step at a time. Got everything crossed for you xxx

@Gizmo1983 only really dawned on me that this is actually happening again. Trying to remain calm. Thank you ❤️ xxx

Big hello to everyone. I hope it’s ok if I join? I have just started treatment with Professor Shehata after finding him through some of you lovely ladies posting on a previous thread so big thank you.

I’ve had 5 losses (1 before my 17 month old was born in 2022) and then 4 in the last 9 months. I have high NK cells and am on the higher dose of Prednisolone and Cyclogest, along with aspirin and all the regular vits.

Clearblue digital ovulation test showed static smiling face yesterday so I started on all the meds today. I have read that a lot of people didn’t start until 3DPO on the Pred but my partner argued that there was no point in spending all the money at the clinic if we’re not going to follow instructions 100%. Anyone else know if day of ovulation vs later definitively makes a difference re implantation?

I also read that the pessaries are best inserted rectally as there’s no mess and less likely to irritate the cervix and therefore decreases risk of spotting. I did this tonight for the first time and found quite uncomfortable. I’m too scared to try vaginally though in case of spotting.

Any tips gratefully received and lovely to (kinda) meet you all!

Hi @Thornters welcome to the group 😊. I’d stick to what Mr Shehata says it’s more the cyclogest you need to be sure you dont use too early. I’ve tried the cyclogest rectally and vaginally and I prefer rectally in honesty neither are great. Vaginally it goes everywhere and can make you prone to thrush if you suffer with it. Rectally always upsets my stomach at first I just get used to them and then it’s time to stop. Try them both ways and see which you prefer it’s a personal choice 😊

Thanks so much @Gizmo1983 I have had thrush a few times before so will likely stick to the back way if I can hack it or will try vaginally if needed.

I started both the Pred and Cyclogest today (Pred in the morning and Cyclogest about an hour ago). Pretty sure I ovulated today based on the CB ovulation test and EWCM but I had a scan on Monday and the sonographer said tomorrow most likely ovulation day so hope I haven’t started it too early - eeek.

Don’t worry take the 1st month as your learning curve I’m sure it wont matter too much worst thing you can do is stress just relax and go with it. I get thrush so have to do anally. I’ve been on mr Ss plan since February no luck so far ( had a chemical last month) and starting ivf in June so this is my last shot naturally. I got my peak today so should ovulate tomorrow although got ovulation pain now so today/tomorrow so we are pretty much the same time 😊

Oh @Gizmo1983 I’m so sorry to hear about last month. It’s so hard when you think they’ve cracked it with all the testing and the meds. Ooooh ovulation twins 😊 Wishing you all the luck for this month!

I am feeling a lot of pressure as we decided we are only able to try for 6 more cycles (from a cost, psychological and age point of view - I’m 40 end of this year and partner is nearly 43). I know this won’t help so need to try and relax and find ways to distract myself.

Hi @Thornters thank you so much ☺️ the chemical has affected me in a strange way in that i actually feel like a weight has been lifted I can’t really explain it. In June I had a 15 week loss where we had to have a funeral if we wanted her ashes and that was so devastating I think maybe the chemical seemed so easy after that I’m really not sure.
I will be 41 in July we started trying when I was 39 so now I feel very old and is why we are starting ivf in June I don’t think we dare leave it any longer. We also found my left tube is blocked so ivf is probably our best shot at all this now. One of my good friends had her baby last year at first try aged 46 and my neighbor had a baby at 43 after years of trying and failed ivf so there are little miracles out there I am hoping for me and us on here to be one.
yes I think we are defo ovulation twinnies so here’s hoping 🤞 😊. I tried to clean my diet up this month but after the chemical I just ate what I wanted and have struggled to stop eating rubbish but I’m in a good place mentally so hoping that counts for more 🤪🤪🤪.
@Sunflower360 how are u feeling
@lozzmax hope you’re ok after your hysto
@Rainbowsunshine81 hope all went well and have a safe flight
@VenusStarr how are you doing sweet
love and hugs to all xxx🥰

@Gizmo1983 I'm ok thanks, just counting down to the first scan-still no noticeable symptoms! So until the scan or noticeable symptoms it won't feel real I don't think.

It sounds like you've been through so much, TTC can be such a cruel and tough journey, but then for others so straight forward. Hope you're ok

Hi @Sunflower360 aw thank you yes I’m ok I’m in the best place I’ve been for a while, looking forward and not back 😊
I remember Dr Shehata saying the meds we are on can suppress any symptoms so I’m sure it’s just that. When do you get your first scan xxx