Hello everyone! Hope everyone is doing well - I started to catch up but I'm too slow at reading and the puppy doesn't let me scroll on my phone for very long! Any time the puppy is sleeping is spent working/cleaning/cooking/ eating/dealing with builders/sleeping ... having a puppy on a building site is HARD.
I've missed some BFPs though - quiet congratulations to you all.
On my side we have been for our private tests at Dr Shehata's clinic in Epsom, got the results and started a treatment plan. I have high NK cells and high NK cell activation levels, and also high TNF alpha. These can all cause miscarriage according to this doctor and the TNF alpha in particular can cause issues with implantation and hence cause chemicals. OH is waiting for his DNA fragmentation sperm test. The tests cost £2,700 in total.
I've been prescribed some scary drugs to try and bring down my levels - adalimumab injections (only x2 thankfully as I cried doing the first one on the weekend- I'm such a wuss I take my hat off to all ivf ladies doing regular injections) for the TNF alpha. This cost £400.
Then phase 2 I will go to Epsom once a month before ovulation for intralipid infusions. From ovulation for 10 days I will take prednisolone, omeprazole and Cyclogest. On 10dpo I should do a FRER and if negative, stop all the drugs. The intralipids cost £380 a pop, the others will cost about £100 per month, so I'm looking at £500 a month just TTC.
I'm also on low dose aspirin every day, 2000iu vitamin D, omega 3 and proceive (the clinic days any multi vitamin). OH is on Impryl.
Once I get a positive test I have to rush down to Epsom within 4 days for intralipids. So I've had to tell work, my manager was very supportive actually. Luckily I'm not looking for a promotion or anything so I don't have those worries in the back of my mind now that they know I'm TTC.
It is a lot to take in and costs a lot (although I think less than IVF) but I feel like I don't have a choice. 5 losses is 5 too many and I feel like I need to try anything and everything to prevent another. Now that we know I have high NK cells I have to do something about it - trying again without medication seems out of the question.
The worry is these drugs are not officially licensed for use for TTC/ pregnancy in the UK as they have not been proven to be safe or effective in large scale clinical trials. The clinic I am at has an 80% success rate so I'm hoping it does work and perhaps it will become the normal treatment in future. The drugs are immunosuppressants which is scary in a pandemic.
I've also just had a scary side effect of going to the loo and there was blood in my poop 😳 which could be a side effect of the adalimumab or even the aspirin. It was like being on a normal period but from the wrong place 😱 so I've emailed the clinic and they've just said it's not connected and I need to speak to my gp. But the leaflet for the drug says it can commonly cause gastrointestinal bleeding and I've never had this before so I'm upset they have dismissed me. Surely the GP will simply tell me to stop taking the drugs and give me a telling off for taking stuff unnecessarily!
It's a minefield out there ladies, I have no idea what's going on. I hope we all get babies at the end of this.