Only info from in laws. When MIL was pregnant with DH she had testing (I guess amniocentesis but not sure, she doesn't know) and he was found to have a translocated chromosome. So he had been told a huge doom and gloom horror story of infertility, miscarriage, possible learning difficulties etc. Actually he is dyslexic but that is probably nothing to do with it.
So went into this relationship knowing that there was a chance it wouldn't be easy for us and he was open about it from the start, and I decided that if it happened it happened and if it doesn't then we'll deal with it. I know he'll make a great dad, he already does. We've always been fairly lax about contraception once we knew the relationship was serious but no accidents or anything. I was on the pill for a while, we sporadically used condoms. We decided to try for a bit about three years ago and then he freaked out about finding more information about his condition so we decided to give it a break. By this point I'd read everything I could off the freely available stuff on the web.
Came back to it about a year or two later and he was okay with testing but I wanted to do some career stuff first so we planned to hold off for 2 years and then he went to visit his family and his friend who had a newborn and came back and gave me this big pitch and so we decided to do it for real, which was a proper rollercoaster because it brought up a load of unresolved feelings about me having DS so young etc. What was almost cruel is that it worked the first month, which we weren't expecting at all. We lost that one at 5 weeks, and I was sad but he was absolutely gutted. I didn't feel like I'd invested into the pregnancy yet, so it didn't really feel like I had lost a baby. Second miscarriage was three months later, exact same gestation and again, sad, but I felt okay because at least we were getting somewhere! Waited another 3 months... 5 months... felt v frustrated because it was almost like I felt I'd just paused that first pregnancy and I wanted to get back to it. The miscarriages just felt like the most monumental waste of time. Now of course in perspective, losing 1-2 months was nothing! So it's a different feeling now.
Recently I went a bit mad trying to find stats and driving myself crazy so I ended up joining a facebook group about translocation and reading everything on there basically. It's helped because of the information thing. I have a tendency to be overly optimistic in the sense that I almost CAN'T see the worst case scenario, whereas DH is quite good at assessing a situation for how it really is but tends to present it quite negatively to my view. The group at first gave me hope, then brought me down to earth, now I'm back where I was, hopeful, but more realistic than before. At the moment he hasn't given up hope so that's probably a good sign, but I'll wait and see after we speak to the geneticist. He will probably get a bleaker version of events than me.
One of the things which can happen with a translocation is that the pregnancy fails to implant to begin with, rather than causing a miscarriage, so it might be that's what's been happening. But there's no way to know that.
Anyway, I'm not sure why I've rambled so much. Translocation is very rare apparently but it's one of the few things which can cause miscarriage from the man's side.