Thread for anyone TTC for over ten months. Please feel free to join us!
Took the liberty of starting a new thread (with what is obviously a brilliant piece of rhyme!) as I assume everyone else is sleeping peacefully right now :)
Please or to access all these features
Please
or
to access all these features
When's the best time to get pregnant? Use our interactive ovulation calculator to work out when you're most fertile and most likely to conceive.
Conception
TTC for 10 months or more, and now we're moving onto thread 4! Ten plussers welcome!
998 replies
MPP81 · 05/04/2016 01:12
OP posts:
JustTrixie ·
13/04/2016 10:12
Morning everyone!
Good luck with your appointment Banana and good luck with your scan later Lucie.
Sammy, I also think your list of questions for your follow up is really good and echo what Lucie and Banana say re immunes/lining. I would be tempted to do the immune tests via Serum like Banana and also any blood tests your GP can offer (mine did quite a few for me). Your lining was thicker on your second cycle to your first wasn't it and with everything you are doing plus the acupuncture which is great for blood flow to the uterus hopefully it will be even thicker next time. I am also terrified of my next cycle not working but am trying to remind myself that this cycle is different as I am having immune treatment. Have you thought about making use of the counselling appointments? I remember you mentioning that it helped before.
Hope you're feeling better today Rebecca.
I checked my Gestone last night and I actually have 5 injections not 1 so that is a good start. They are ampules though as are my stimms this time and I've not used them before so slightly apprehensive but have watched some videos online so hopefully all will be ok.
bananafish81 ·
13/04/2016 15:00
Hi ladies, will reply to you all with personals, just updating you with the news from this morning
So the genetic testing showed our baby was chromosomally normal 
It’s possible there were microdeletions, tiny chromosomal changes that are too small to be detected by cytogenetic analysis, but no obvious genetic abnormalities
Our Dr said he and his wife had also had a miscarriage where the testing showed the baby was genetically normal, and no obvious cause (and subsequently went on to have healthy pregnancies)
There are no clear answers for why we lost the baby. The best theory we have is to do with the quality of the endometrium. My lining has been a consistent problem in all my natural cycles, it just doesn’t grow (because of sleepy oestrogen receptors) - although I’ve been ovulating, I haven’t really been menstruating. So although it thickened up in response to oestrogen, if the lining never properly regenerated, it’s possible the foundations essentially weren’t strong enough to go the distance.
We don’t know if this was why the pregnancy failed. But it’s our best guess.
The research by Prof Quenby & Brosens into repeat miscarriage being due to the regeneration of the endometrium during menstruation before fertilisation even takes place, determining whether or not a pregnancy will miscarry, seems to point to this as a possibility
Because my endometrium did thicken up, once my hCG levels fall, for the first time I should have enough to shed, so we can have a proper clear out.
The hope is that my body has learned how to be pregnant, and that if we start from a clean slate, that the lining can regenerate, hopefully with stronger foundations.
So quality as well as quantity it seems is as true for lining as it is for eggs.
We know I didn’t have implantation failure. And we know I had a decent egg in there that made a good embryo.
My immunes tests didn’t know any major immunological problems or thrombophilia. Tests showed marginally elevated NK cells, which seem unlikely to have been the root cause of the miscarriage. But we’ll treat with prednisolone, intralipids, clexane and aspirin next time to suppress any NK cell overactivity, and to ensure increased blood flow.
PGS wouldn’t have made any difference to this pregnancy, as we seem to have had a good seed, but unfortunately the soil just wasn’t right this time.
Just very, very sad
We are repeating the beta on Friday, then probably again next week
If it’s not going down fast enough, we will do a hysteroscopy in 2 weeks time, so he can go in with a camera and check out the uterine environment, see if there are any tiny fragments of tissue left behind
He’ll do a scratch while he’s in there, to help support implantation for our next transfer (although implantation wasn’t our problem)
As soon as my hormones are back to normal, we can start stims ASAP. Just have to wait for my body to let go of trying to be pregnant
stealthbanana ·
13/04/2016 21:04
Oh lucie what dreadful news. Am so so sorry
Crap day on the board all round really. Much love to everyone. So glad we can support each other xxx
Don’t want to miss threads like this?
Weekly
Sign up to our weekly round up and get all the best threads sent straight to your inbox!
Log in to update your newsletter preferences.
You've subscribed!
Brenna24 ·
13/04/2016 22:48
I am so sorry Lucie . It is so unfair.
Banana I am so sorry there wasn't a clear problem. But as you said smaller deletions or inversions wouldn't show up and sometimes things just don't work properly even when the chromosomes seem ok. I hope that another shot with a thicker lining will do the trick for you.
Please create an account
To comment on this thread you need to create a Mumsnet account.