Immune /natural killer cell treatment when ttc or pregnant (aka the 16th pred thread!)

[sunnyday01]

This is a thread for those diagnosed with high or very high natural killer cells and trying to concieve or are pregnant and taking steroids/intralipids etc

Newcomers very welcome

* Snoopy * Sorry to hear work are now being so unhelpful with everything you've been through. I've needed time off after both ERPCs & after finding out about the third MC. Then while waiting for RMC results had meltdown & couldn't face work for a week - it is so hard. Perhaps just ask them to clarify in writing that miscarriages are not deemed "pregnancy related" - & take it to an employment lawyer!

So I am now officially one of you! My NK count & all standard NHS tests were normal but activity level just over the 20% threshold for high & thankfully down to

Welcome Morgan. Glad. U feel like u have answers and glad ur resulfs have responded to the tx. I'm sorry I don't remember ur history now but please do join us!

Snoopy get some sleep tonight and have a think re Gp/counseller etc. Hope work are ok tmrw

Thanks for ur kind words tonight girls, I'm dreading the next few days. Just wish I could feel more hopeful. I'm sure my back cramps have got more obvious but I'm just so hyper aware I can't tell. I'll know either way soon. For now I need some rest! I feel like I'm going slowly mad! Xxx

Snoopy found a few links that may help but the citzens advice bureau one makes it clear that miscarriage IS pregnancy related sickness.

www.citizensadvice.org.uk/work/discrimination-at-work/what-are-the-different-types-of-discrimination/pregnancy-and-maternity-discrimination-at-work-specific-situations/

www.equalityhumanrights.com/private-and-public-sector-guidance/employing-people/managing-workers/working-hours-and-time/making-decision-relating-time/pregnancy-related-absence

www.miscarriageassociation.org.uk/wp/wp-content/leaflets/Miscarriage-and-the-Workplace.pdf

Trying - hope you can get some sleep. Fingers crossed for your results.

Thanks for the links hula

trying let us know when you get your results.

I'm just tired and anxious but I will get through this. Just have to find the strength to keep going

Trying Thank you.

My summary is: 30, 1 DD born 2013, then MMC Summer 2014 where heartbeat stopped between 8-10/40 scans & needed a MVA under local, spontaneous natural MC of probably a blighted ovum started at about 6/40 Autumn 2014 and another MMC Spring 2015 where again we got to just over 8/40 size & know that one was a genetically normal little boy.

I've been following your pred thread for s while as I felt like it's something autoimmune/placental development going wrong - but the standard NHS tests including NK count were normal. Now feel relieved (!) to know that they're high activity but responsive to pred as can daydream maybe things will be different if there's a next time!

Hcg only 438. Way too low. Absolutely devastated. Been told it's rise that's imp but doesn't sound good.
Literally don't know where I go from here :(

Hope everyone else ok x

Oh Trying im sorry this has just brought you more worry but it really is whether its doubling thats relevant so please don t give up hope. I take it you ve got another test tomorrow, is there anyway you can get the results the same day to at least reduce the amount of time you are waiting to know. Have u spoken to your ivf clinic about the results. Are you about 5 and half weeks ? Bigs hugs, i know this is horrid not knowing, i wish i could do something more.

I'm sorry trying, try not to write it off yet as I have read that hcg levels can vary day to day, and week to week, not just pregnancy to pregnancy (although I'm no expert as nd er had hcg levels done).

I agree with hula, is it worth contacting your ivf place about the results x

I'm going to try get results tmrw by driving to the hosp where they get sent to. Hopefully that will speed it up.

But I know the result, I'm clutching at straws to think this may be ok. I literally don't know what to do. With the low sperm count im really thinking our days of trying are coming to an end. My head is a mess. I seem to be able to get a BFP but can't keep it. I'm being covered for every possibility but now we are eonderin of it's the sperm? fragmention etc that's casuing an issue.
Currently we are thinking of giving it all up and just going to the argc where they do daily monitoring. Obv this means jobs and lives thrown away. Also there's no promise they can help a man with no soerm and a woman who keeps miscarrying :(
Xxx

I've rung them. Waiting for consultant to ring me back.

Thanks guys. Think I need to start replanning what my life may look like :(

Ah trying it's so hard, there's nothing I can say to make you feel better, but I'm thinking of you x

Let's us know what co sultans says etc x

Trying I'm so sorry the numbers are on the low side. What exactly were your dates when you had the blood taken?

I know it's upsetting but why would this be the end of the road? You have more opportunities to try, can continue to collect sperm, and maybe this can help identify if there is another issue? Had they not checked for sperm fragmentation. Also as you're freezing the sperm, each time you try it's in a controlled environment that increases your chances of success.

Hang in there Hun :( xx

Sorry the fragmentation sentence was meant to be a question!

trying I'm so sorry it's not the result you wanted but please don't lose hope until you've had the second test back. And please don't give up. We're all here for you x

Thanks guys.

Frozen sperm doesn't defrost well it looses mobility and some die. They don't keep same quality. If dna fragmention is an issue, the sperm we have saved up to now (enough for 1 cycle-so about 30 sperm given a lot die) are shit and fragmented. Urology appt in 2 weeks so will be really good to hear what he thinks we should do.

My feeling is trying quickly again with fresh sperm while there may still be some Production is the way forward. Who knows when it will go to zero. It went from 5 million to just over zero in 2 months.

prob going to book an appt with argc tmrw when I have a 100 percent answer but already rung them and their wait times are 6-8 weeks.

Snoopy how r u today?
Yes hula im 5 plus 4 yest and 20 days post 5 day transfer
Sorry to be a mega downer, thanks for all ur kind words.

trying you are not a downer! This is where we can vent our feelings with people who understand and don't judge. If you need to rant then go ahead, if you need to cry then that's fine too.

I'm just trying to get on with it. It's tough working different times to DH but I need to get used to it

Trying don t apologise, thats what we re here for. From googling charts wk 5 seems to have the highest variability (some said at normal level was 18-7000 !) so this really is just a baseline. Try not to think too far ahead, just focus on trying to stay calm and get through the next 24 hours. I m hoping with all i ve got you get doubled numbers tomorrow.

I hope thats was clear that is was a range from 18 to 7000 (not 187000).

I have seen that hula. Find it v hard to believe. Thanks for trying to be hopeful for me. Online forums suggest 10000s by now. Anyways yes will know tmrw.
Sigh.
When r u testing? We due more good news on here, I hope it's u next x

Why do I never bleed. How many d and c can one person have in their life :(

Trying So sorry to hear what you're going through - as people have said it's still not definitely over even if you're feeling realistically pessimistic.
If it is then I think the keep going with fresh sperm is a great plan - we obsess over our eggs/lining then all it can take is 1 sperm! My two baby bombs from close friends since I started having miscarriages had both been trying for over a year & a half to conceive with men with known sperm issues - but then they did & that one got them their babies!
How many D&Cs have you had now? I've had 2MMC (+ 1 natural) & reframed it in my mind as rather than my body failing to do & MC naturally as the foetus/baby & my body wanting to stay as close as possible for as long as possible and not let go - which although really sad gave me comfort in some strange way.

Trying - i hope you re ok. Thinking of you.

Yes, sending you a big hug trying xx

Levels down to 391. :(
Hoping if I stop all the meds it may happen naturally? Ow I'll book a d and c tmrw.
Sigh. Thanks for thinking of me
Xxx