Anyone taking part in the Response Medical Trial or any other medical trial?

[sizethree]

Hi, I'm taking part in the Response medical trial and wondering if anyone else on here is too?
It's been a very difficult year and a half and I have had three consecutive miscarriages, 1st in Nov 2013 at 12 weeks, 2nd in July 2014 at 7 weeks, 3rd in Nov 2014 at 9 weeks. It's a 4 month waiting list for my Recurrent Miscarriage Clinic so I'm taking part in the trial as want to keep things moving as worried I'm running out of time (I'm 36 this year - although I was 33 when first started TTC) but I'm in the 2WW and feeling terrified.
There's a lot of extra support offered as part of the trial but I'm feeling a bit lonely and out on a limb about it.
Anyone else on the same boat or had medical trial experience?

I've arranged time away from the office so I can make my appointment tomorrow .

size, I've never actually seen any scans of my babies. My first pregnancy was when I was still a teenager and not all ready for the responsibility of being a parent, my second pregnancy was when I was at uni and I miscarried just about the same time I suspected I had fallen pregnant again. My third miscarried at 11 weeks before I'd had a scan, but the pregnancy products (I hate that phrase) were visible on a scan and the fourth was a biochemical pregnancy that miscarried at 5 weeks without a sac developing, so nothing to see on the scan. Luckily for getting considered for the trial I had hcg blood tests that confirmed that I had been pregnant the last time. I've got real mixed feelings about seeing a future scan but don't think I'll be able to stop myself if there's a sticky bean in there. I'm in the north west and will be going to Manchester.

choccy, yes, my manager knows about my losses, I've told him about my pregnancies as then I'm covered by equalities legislation. And I'm pleased what you've all said the about the injections sounds pretty tame and manageable.

Am a bit worried that the Dr's might not think my first miscarriage counts as it was never confirmed by a pg test but I just know in my heart of hearts that I had a MC, and not just a one off freaky 3 week period. Oh well, I;ll wait and see what they say .

Good luck tomorrow Mimi. I only had two of my three MC's confirmed by a medical professional but it wasn't an issue as the criteria only stipulates two have to be confirmed.

Dh is in my bad books as he's decided he doesn't want to start ttc this month as if I was to fall pregnant then the due date would be Xmas day! Wish he would have expressed his opinion earlier ??

Anyway going to start ov testing tomorrow anyway and in the meantime I will work on DH.

so pleased you can make appointment tomorrow Mimi. I've my fingers crossed for you.

Oh no girlie I would be furious with dh, are you annoyed?. what cycle day you on? I'm on CD10 so started ov testing today, negative of course as still a bit soon but rather that than miss it. my dh has said a few times that if I keep miscarrying he would prefer to give up and be happy with what we have.....it upsets me so much when he says it. he just doesn't get it.....so annoying and worrying tbh.x

I am annoyed with DH Claire. I can sort of see his point about Xmas due date but the real reason he wants to wait is because he wants to go on holiday, which I've said once I'm pregnant that I won't want to go away in the first 12 wks (very different from Dd's pregnant as went to Cuba when 6wks pregnant) so he wants to go soon. Anyway told him he needs to sort out my passport first so we'll see.

I'm CD08 but going to start testing tomorrow as last AF was 5 days late and pushed forward average cycle length so airing on the side of caution.

Hello ladies, hoping I can join you... I have just signed up for the trial, after having 3 miscarriages at 7, 5 and 8 weeks pg. I have a dd who is nearly 3. I am up in Edinburgh and had my initial appointment last Monday when I was sent off with my tote bag! My last miscarriage was at Christmas time and had a D&C on 5th Jan. 6 weeks later my hcg levels were still at 900 and after a scan scan they discovered some leftover tissue so had a second D&c on 26th Feb. Finally got neg preg test last weekend. No idea when I might ov again as I have really long and unpredictable cycles so not too sure when to start the opks! Am both excited and nervous about starting trial. Looking forward to chatting to others on here!

Welcome Meemes, you can certainly join us. I'm at the same stage trying to get my head around ov etc.

Ok, first morning of using the ov tests was a disaster as firstly I tried to be clever and set the test up before I went to bed but turns out test didn't like that and had an error message. Secondly turns out can't pee
In straight line, so pretty much covered my hand but not the blooming stick and again another error message.

Off to buy some paper cups to collect the pee today and start again tomorrow. Glad I started a few days early!

Girlie just use the lid of something like air freshener, hairspray, deodorant etc
And re your DH, he does realise there is no guarantee you'll get pregnant on a certain day yes?

Claire my Dh was the same. After so many losses he'd had enough. Now I'm actually pregnant, especially seeing baby with arms and legs friday, he's really excited. Especially as we already have Ds so he knows what to expect now!

Re mc confirmations I only had one confirmed. They were so early that my booked scans were after my losses but one was still there when I started bleeding hence the confirmation. It was borderline if I'd get on the trial but I did :) so glad now!!

Welcome to the nuthouse meemes!

girlie and choccy, thanks for the reassurance about pg history, having been feeling like a bit of a fraud for trying to get on the trial. Especially as my GP wasn't very encouraging about my eligibility.

claire, am on train on way to the appointment and have just realised I haven't got a clue what to expect . I probably should have picked your collective brains beforehand. Oh well, it will all be revealed to me shortly .

girlie I'm so sorry your DH has thrown that at you. Must be so frustration with such a short heads up timeframe of what he's thinking. I can see that a due date of that particular significance would be very sad, but equally any due date is shitty to get through. There's no easy answer is there. I hope you get the chan e to talk it though and come to a decision together.
Ironically my due date for this is fireworks day. Ffs, 'remember remember the 5th of November' not going to forget that easily!
Gosh claire it must be international blunt husband day as saying that is very clumsy. If be very upset too. Settling with what you have no way compensates for not having a new baby.
All of us who have suffered recurrent miscarriage have been through an incredibly sad time. But I do have extra empathy for you all as already having a child and not struggling with that journey must make the battle to have the second even more unfair and torturous.
For me as I am yet to have one, I don't know what I'm missing out on as clearly and this battle is all I've ever known about pregnancy. I can see how gruelling it must be to have an opposite journey the next time around.
choccy am I right in thinking your scan in i weds this week? Into double figure weeks now!
Mimi let us know how your appointment went asap. And if that damn bag left brown fuzz all over your jeans/tights!
Welcome meems I'm a fellow Edinburger too. How exciting!
I'm being very well looked after and as I'm sure you'll know the staff are lovely.
I have 3 MCs. At 12, 8 & 9 weeks. Incurrently 8+4 and shitting myself with nerves. I'm a bit of a complicated one as the tests for my last loss showed a rare chromosomal abnormality (which they didn't tell me about until 4 months aftet) and I'd already fallen pregnant with this one and on the trial. So a fair amount of drama going on with me at the moment and me and my DH are waiting for out karyotyping results coming back mid week. My 8 week scan was in Thursday and everything was looking normal at that point so here's hoping things tick along nicely and the testing comes back that we are both absolutely middle of the road boringly normal.
Never a dull moment in this thread!

Let us know how you get on Mimi.

sizethree how you doing? So should you hear this week? thinking of you.

my dh is also saying once I am 35 (next Aug) he wants to stop trying due to the risk of miscarriage naturally increasing wft honestly he makes me so upset at times, makes me feel like I'm doing this alone and its only me that feels this way. sometimes I could smack him....not this week though as hopefully I 'll o later this week!! he has his uses!!

choccy I can't remember if you said today for scan or wed if today hope all ok.
girlie what a morning you have had!! one of my holders kept showing an error last month ended up I needed to use a new holder. I use one of ds plastic cups as I would flood it too!!xx

welcome meems . xx

claire yes I should get the results mid week, so probably weds/ thurs.
Gosh gosh DH can be a bit blunt can't he! It's not like one minute the MC risk is one number and the second you wake up on your 35th birthday there's a massive shift to a much higher number!
I started TTC at 33. I'm 36 in September but there's been no noticable shift in my ability to fall pregnant in that time nor the quality of pregnancy. They were at shit as 33 as they are at 35!
Also, there's TONS of women over 40 who I see waddling around with big smug pregnancy bumps AND women puffing away on fags while clearly pregnant so the whole over 35 stat accounts for those who are not hot on their own healthcare too.

size glad you get results this week how you feeling about getting them? at least you 'll know next step.
my dh is so blunt isn't he. he says it's turned out lives upside down and made me miserable and doesn't want this for the next how ever many years. he knows how much it means to me and he does want another but he's much more black & white than I am. drives me mad and makes me sad, so pray it's works out for us. I've got an appointment with my consultant at the miscarriage clinic next Tuesday think to go through blood results but not 100% sure why her Secretary didn't say x

Claire I was 35 in November, I was always a little with having one this late due to the risks. My dh wanted to stop trying when he was 41 mid May. I know Yey do sound blunt, but we can't forget that even though they're not physically going through this, it's happening to them too. My dh hated seeing me lose one after another and said how long are you going to do this to yourself. I changed, and in turn it changed how I was as a wife and a mother which were really my prorities.
I became obsessed with becoming pregnant that I totally shunned everything else.
I agreed with the May thing, there DID have to be a finish, but it made me even more determined and here I am!
I think they just don't know how to word certain things and it just comes across a bit harsh.

Good luck mimi!

My appt is today at 3 :)

I thought it was today choccy hope it goes ok.

I totally get that I'm miserable and I've no doubt it's changed me as a wife and a mummy. he hates me going through it just like your dh I just wish he would be a bit more considerate. it makes me feel like what I've been through is for nothing. we 've been trying a year its not like its forever but I do understand it also effects him. I'm just so desperate Which is an awful way to feel. until someone says to me I cannot have another I feel like I will never want to give up but guess if its not meant to be then its not meant to be x

Get you Claire! I always said I wish someone would just tell me I couldn't have another andh at would be that, but the thought you CAN get pregnant makes you want to not give up. You'll get there I'm sure, jeez if I finally got a sticky one, anyone can!! And 8 isn't a lot when you got women out there in their 10s and 20s. I don't know how their bodies cope!

gosh choccy the thought of 8 makes me want to cry. I honestly dont know how you 've coped x

Nor me if I'm totally honest, but here we are 10+1 with a VERY wriggly baby!! Wouldn't wake up at first and someone said something and I laughed and woke him/her up
I have very excited trial mws! They both came into scan lol along with another lady who works in the same office but doing another trial, they're all so excited ha ha!

Ahh I love it that your 've got such lovely ladies supporting you. I'm so pleased all is okay this time x

Thanks for the tips for ov testing. Got my cup ready for tomorrow morning!

The reason Dh has raised about due dates, is upto now I've fallen pregnant at the first or second month each time of trying. It's staying pregnant that seems to be the issue. Anyway that's why he's started to plan. We've reached a compromise that we're going to ear-mark a week at beginning of May to go on holiday if I'm not pregnant and won't need to be around testing in case I have fallen by then. So we'll see what happens but we're back to ttc this month.

Liked discussion around age. As the "old one" at the grand age of 37, my MC have only started since we started for a sibling so it could be age related however the consultant told me it's highly unlikely that it is a cause as I was 34 when I had DD and it doesn't significant change much between 34 & 37. So we're going to keep trying this year and see where we are by I'm 38- yikes!

Choccy- glad to hear scan went well

Meems- how did you're appointment go?

Waves to Size & Claire x

Sorry meant to ask Mimi, how the appointment went!

(Long first day back at work ??)

Thanks for the welcome! I'll try and get up to speed with everyone's situation (hope that's the right word)! I'm sorry if I don't always manage to comment regularly, I have a pretty full on job and don't often get chance to catch up with the thread til this time in the evening.

Great scan photo Choccy, pleased all went well. X

Morning, succeed with the ov test this morning- hurrah! Definitely easier using a cup! X

Lol girlie! I almost spat out my tea when I read your comment yesterday! Blank circle?

Mimi how was your appt?

Claire have you started testing?

Size do you know when you get your results?

Meems, just pop on when you can, we're always here :)