Getting drunk: I like a beer, I like a nice glass of wine. I no longer have any interest in getting shitfaced. Feels crap at the time and worse the next day. I'd guess using drugs would fit this category as well, but it's been a long time.
Nightclubs: too loud to talk, someone else's choice of music (and rarely someone whose taste is interesting), poor choice of (usually overpriced) drinks. Maybe a small town thing, but usually full of wankers as well.
Music festivals / arena gigs: been there, done it. No more. I want a venue where I can (metaphorically) reach out and touch the performers. Sure, I won't get to see Depeche Mode again, but I've made my piece with that.
Fan zones at sporting events: either go to the arena and watch in person, go to the pub and watch with your mates, or stay home and watch on TV. Fan zones combine all the worst elements of those three with none of the benefits.
Meet the maker events and similar: I like the work, but that doesn't mean I'm necessarily fascinated by how it's done. And even if I am curious, I'd far rather read a perceptive interview with the creator or have a one-to-one chat instead of joining a group to be shown the process on a brisk and brief tour.
But a few that I love: live sport, at all levels. I've watched football matches with more people on the pitch than in the crowd, and I've worked at the Olympics. Any one individual event can be disappointing, but the experiences I've had travelling around the world following sports are unmatched.
Live performance: whether it's music (although see above for size of venue), theatre, comedy, dance, whatever, you can't beat that sense of being there. Also, I'd argue, the shared experience with the rest of the audience is an enhancement compared with streaming a show at home or listening to my playlists.
Physical media: reading a book is objectively more satisfying than reading off Kindle. Reading a newspaper is more rewarding that going to a website. I still have CDs (mostly in the car now) and DVDs. I print off a lot of photos.
And related, shopping in person rather than online: exceptions for things like booking transport, hotels etc, but the social contacts of going into town, browsing stores, selecting things that catch my eye rather than going where the algorithm steers me. It's a better way, honest.