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AIBU?

Share your dilemmas and get honest opinions from other Mumsnetters.

To think it will be revealed WLI cause physical aging

830 replies

Tuliptana · 02/03/2026 07:14

Obviously the pictures of Kelly Osbourne are both sad and terrifying.

But a few women i know have also used this method for weight loss and their skin has lost elasticity. They look at least 10 years older. Is this side effect being under played?

OP posts:
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18
Binus · 02/03/2026 08:19

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Do you have a lot of scientific expertise then?

RingoJuice · 02/03/2026 08:19

GargoylesofBeelzebub · 02/03/2026 08:16

There is emerging evidence showing that GLP1s are actually anti aging. You are confusing saggy skin making people look older with aging.

This seems to be the case. It just makes you look older but any extreme weight loss would make this happen. Skin just doesn’t snap back like that (as anyone who has gone through pregnancy can attest …)

TheBlueKoala · 02/03/2026 08:21

Disturbia81 · 02/03/2026 08:19

Yes people do look older but they look 100% better being a healthy weight. Who wants to be wrinkle free but fat and unhappy?

A healthy weight yes ofcourse. I think the OP was referring to people looking like they are dying because they are underweight and on wli.

AmandaBrotzman · 02/03/2026 08:21

ChattyCatty25 · 02/03/2026 08:17

YANBU - it’s known that the injections cause muscle wastage as well as fat loss. I think that’s why Kelly looks so bad, she’s also lost muscle tone off her face as well as padding.

A) she had a gastric sleeve B) she had buccal fat removal

SuzyFandango · 02/03/2026 08:22

Binus · 02/03/2026 08:15

Well the first thing to remember is that dress size isn't a remotely scientific measurement. Presumably you don't think M and S joggers and Primark skinny jeans are going to be exactly the same, even if they both say size 12. Lots of women are indeed 5 foot tall, but as someone who's 5 foot 2, I can assure you I did indeed have some size 12 trousers before starting WLIs and having a 31 BMI.

Also you said earlier they were barely even overweight, which means low end of overweight BMI, perhaps 26. But now it's 24. 2 BMI points is actually quite a big difference!

It was an example weight, most of us vary quite a bit as women in their 40s do tend to with perimenopause & desperate attempts at diets etc

Even at bmi 26 you should not be able to access WLI online. These are women who do not look fat, are not obese, have not have health concerns raised by their GP etc, who are accessing it for cosmetic reasons. The nhs ends up picking up ths bill for side effects.

AmandaBrotzman · 02/03/2026 08:22

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It fucking doesn't and you have no evidence that internal organs are suffering other than your own imagination!

Fearlesssloth · 02/03/2026 08:23

Wordsmithery · 02/03/2026 07:22

Well it's not really a side effect of WLI. It's an effect of weight loss, especially rapid weight loss.
And, for me at least, the issue with the Osbournes is not the weight loss but the huge amount of invasive surgeries that have left both of them looking like caricatures of human beings.
I do hope this isn't going to turn into a thread that bashes women who use WLI.

OMG I just googled Kelly Osborne (haven’t seen a picture of her in about 15 years). She is absolutely unrecognisable! She looks like a frail, elderly anorexic lady

Binus · 02/03/2026 08:24

SuzyFandango · 02/03/2026 08:18

Agreed - but then i think all these drugs should be minimised. We don't want to end up like America where the pharma marketing machine is well and truly embedded and its easy to get things like anti depressants etc.

Medicine should be about health. The NHS should be working in partnership with local councils on exercise initiatives etc.

America is the only society that might be reversing it's obesity rates, so actually yes in that respect we probably do. The only thing that's been proven to work is sustained WLI usage. There might be benefits to NHS exercise initiatives, but reversing obesity isn't going to be one of them because exercise doesn't do that.

Also worth pointing out that anyone who's already obese is likely to be fertile ground for Big Pharma anyway. That's already baked in.

Beautifulhaiku · 02/03/2026 08:25

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Just because something feels like it must be true, it doesn’t make it scientifically true.

SuzyFandango · 02/03/2026 08:25

But many of the people accessing these drugs online are not obese.

Don't pretend its impossible to get them. It's not.

Binus · 02/03/2026 08:26

SuzyFandango · 02/03/2026 08:22

It was an example weight, most of us vary quite a bit as women in their 40s do tend to with perimenopause & desperate attempts at diets etc

Even at bmi 26 you should not be able to access WLI online. These are women who do not look fat, are not obese, have not have health concerns raised by their GP etc, who are accessing it for cosmetic reasons. The nhs ends up picking up ths bill for side effects.

If some of them are usually 'barely overweight' but there's a lot of variation then it is in fact quite conceivable that they might meet the medical prescription criteria at some point.

I share your concerns about inappropriate prescription, but you do need to get rid of the idea that whether someone subjectively looks fat to you is remotely relevant.

DarkForces · 02/03/2026 08:26

Wow. The insults on top of the scaremongering are off the charts on this one. Congratulations @Tuliptana . I've not been this insulted before breakfast in my lifetime but there's a first time for everything.
I look like someone with hiv and am dying on the inside? Well very good morning to you too. I hope you have a lovely day

SuzyFandango · 02/03/2026 08:27

To be clear im supportive of wli beinv provided to obese people on the NHS where they can be properly advised and monitored.

Binus · 02/03/2026 08:27

SuzyFandango · 02/03/2026 08:25

But many of the people accessing these drugs online are not obese.

Don't pretend its impossible to get them. It's not.

Genuinely, who do you actually think is doing this? I don't think I've come across anyone who doesn't think there are people dodgily acquiring WLIs. There obviously are.

It's just that this is a separate point from the total invention and wishful thinking some people insist on tagging onto it.

AmythestBangle · 02/03/2026 08:28

@spaghettisweater agreed (although there a huge black market in those, not necessarily online). But the PP's point was about saying (gleefully IMO) that WLI are going to be revealed to have some serious side effect that hasn't yet been discovered. My point is that many drugs have serious side effects. Not all of which all users are aware of when they take them. Antipsychotic users are almost never aware of the possibility of tardiness dyskinesia. The vast majority of antidepressant users have never heard of serotonin syndrome (and antidepressants are in fact very very easy to get). Doctors however prescribe these drugs anyway, even though they know of the potential adverse effects.

Wildviolet · 02/03/2026 08:31

What a load of old shit.
If you don’t like wli, fine. You don’t have take them but stop the boring attempts to spread crap.
It just makes you look jealous and stupid.

DarkForces · 02/03/2026 08:32

SuzyFandango · 02/03/2026 08:27

To be clear im supportive of wli beinv provided to obese people on the NHS where they can be properly advised and monitored.

I'm far less monitored on the drugs prescribed for me on the nhs than I am by the pharmacy who prescribe mj. Where do you think the capacity is to have personalised, holistic care for obesity in the nhs? But don't let facts spoil your assumptions

HeadDeskHeadDesk · 02/03/2026 08:32

Any method leading to relatively rapid and successful weight loss is going to cause loss of elasticity and slackening of the skin, especially in older people. All that loose skin has to go somewhere. I've seen it happen in people who have lost huge amounts of weight via other methods, before WLIs were even invented.

mrschocolatte · 02/03/2026 08:35

Why must we always treat people like idiots in situations like this? I much prefer to think that people who choose to take WLI have the capacity to understand the decision they are making and evaluated the risk. Fair play to them and crack on is what I say. I’ve considered it and decided it’s not for me but I would never judge another person who chose to do it.

Edited as forgot to add that I lost 4 stone once through extreme calorie counting over the space of 6 months. I was in my 20s and aged so badly I was almost relieved when I inevitably put the weight back. So in my mind it’s weight loss that causes changes to the skin rather than the WLI itself.

pinkdelight · 02/03/2026 08:35

Your fixation on internal organs seems a bit loopy. As if losing weight isn't good for your heart etc. Obviously illegal misuse of a prescribed drug isn't wise, but your argument is pure fearmongering based on some extreme cases, people looking like they have HIV(!!) and some bs about silicon breast implants which no one ever said were prescribed for health reasons so there's no similarity. When you have actual evidence that internal organs 'age' in some harmful way just because skin looks less plump on WLI, then let us know.

CautiousLurker2 · 02/03/2026 08:36

I’ve lost 6 stone and am approaching 60. I look 10 years younger and have considerable energy and thus am much fitter and healthier - spent the weekend moving and building furniture into a new house, something I couldn’t have done 3 years ago. My health indices are markedly improved.

The women you are pointing at so derogatorily have a history of drug and/or alcohol abuse and very stressful/difficult personal lives, Sharon particularly with her marriage to Ozzie. She is in her 70s FFS and they are both going through a deeply traumatic bereavement so take your anti WLI narrative and move along.

I’m not big on fillers and cosmetic surgery or the amount of make up they wear, but all that is their personal choice. If you don’t like the effect it really is none of your business.

What a ghoul.

LondonBlueTopaz · 02/03/2026 08:36

AmandaBrotzman · 02/03/2026 08:21

A) she had a gastric sleeve B) she had buccal fat removal

C) This woman has been grieving.

knitnerd90 · 02/03/2026 08:36

Rapid weight loss by any means will produce this effect. It happens to people who have bariatric surgery as well. I know someone who lost a lot of weight rapidly following the death of her husband, and it aged her dramatically.

I don't know what happened to Kelly Osbourne. She denies using injections. She has had a band in the past. Her face looks almost as though she's undergone buccal fat removal. She says it's weight loss following her father's death. God knows, Sharon is no example to follow, and she has said she's used injections (Not that injections are bad per se, I use them for diabetes, but Sharon's done much more).

The problem is that celebrities always deny doing anything even if it's obvious they have (Nicole Kidman, I'm looking at you, I remember your original face). So we never know the truth and start speculating.

AmythestBangle · 02/03/2026 08:38

@fearlesssloth presumably she looks like a person with an eating disorder because she is a person with an eating disorder? That says nothing about WLI. I don't know much about this poor woman but she clearly has mental health challenges, stop using her to bash people on WLI.

Yes, some people with eating disorders have caused themselves harm by taking WLI. That's not in doubt and not a surprise. It has nothing to do with people with a different condition taking the medication. Rich/famous people are always able to get hold of drugs that cause them more harm than good (Matthew Perry, Michael Jackson...and on and on...). That doesn't mean that the drugs they used (misused) dont have uses ( benefits) to other people.

SquashedSquashess · 02/03/2026 08:38

Kelly’s not lost “a bit of weight”, she’s drastically underweight.

Anyone with a severe restrictive eating disorder looks older than their years. Weight loss drugs, used sensibly, don’t severely affect your appearance.