To think it will be revealed WLI cause physical aging

[Tuliptana]

Obviously the pictures of Kelly Osbourne are both sad and terrifying.

But a few women i know have also used this method for weight loss and their skin has lost elasticity. They look at least 10 years older. Is this side effect being under played?

No they're not off label, they're licensed for weight loss. Try again.

A quick google search will tell you they are prescribed off-label for weight loss in the UK, USA, Australia, and EU.

Why does anyone have a problem with this? It’s no different to any other medication.

It's because there are fewer and fewer fat people around now, so there are fewer and fewer people who can be despised.

It's really simple.

They're licensed for weightloss.

GLP-1 medicines for weight loss and diabetes: what you need to know - GOV.UK https://share.google/NMjPXUZdYa5kxZDUS

Oh my god they're really not. They are licenced for weight loss. I cant carry this on. The end.

Oh joy, yet another thread attacking weight loss jabs!
I’d rather be saggy and wrinkly and have vastly improved health markers than carry on being 45+ BMI.
It’s really weird how much people hate that fat people have valid options to lose weight.
If people use it irresponsibly that’s surely on them and their decision? Obviously it’s not great, but plenty of people do bizarre and aging things to themselves in the name of beauty. Meanwhile those using WLIs to genuinely improve their lives and health outcomes can’t win - you’re criticised if you’re fat, and criticised if you lose WLIs even though studies have proven for decades that obese people are unlikely to lose weight and maintain it long term.

Oh my god, indeed. Licenced and off-label have different meanings.

It’s not aggressive, it’s frustration, you’re posting misinformation and won’t even google to check people are even giving you the links. 😂

it doesn’t matter though, you don’t need to take them. Honestly you really don’t. No one will force you, you’re ok.

we will take em though. 😜

🤣🤣🤣🤣🤣

Prescriptions for weight loss if 30 bmi or 27 with health conditions is not off label. It is not off anything, it is fully approved to be prescribed for obesity,

For a peruser of scientific papers, you have a surprisingly low understanding of medical terms.

'Off-label’ use means that the medicine has a license for treating some conditions, but that the manufacturer of the medicine has not applied for a license for it to be used to treat your condition. See https://www.hey.nhs.uk/patient-leaflet/unlicensed-off-label-medicines/. Here is the information about which glp1s are licensed for weight loss and prescribing criteria. https://www.gov.uk/government/publications/glp-1-medicines-for-weight-loss-and-diabetes-what-you-need-to-know/glp-1-medicines-for-weight-loss-and-diabetes-what-you-need-to-know

Wow. I just can’t 😂

European Medicines Agency authorisation for Mounjaro:

Therapeutic area (MeSH)
Diabetes Mellitus, Type 2
Obesity
Overweight

Authorised in the EU by the European Medicines Agency for two main indications:

1. Type 2 diabetes
2. Weight management in adults with:

BMI ≥ 30 (obesity), or BMI ≥ 27 with at least one weight-related condition

It is not used off label for weight loss when used with those indications.

I take a low level anti-psychotic to help with sickness from migraines (prochlorperazine). OTC FFS. Where’s all the concern?

Yes, of course it's a benefit. I'm not against anyone taking any medication for any condition.

It's not using an existing drug for a totally new purpose. These drugs mimic the hormone Glucagon-like peptide-1. They reduce appetite, slow gastric emptying & improve glucose control. Those effects lead to lower blood sugar in people with Type 2 diabetes and weight loss in people with obesity. It's not some unrelated random finding. Obesity is one of the main risk factors for type 2 diabetes, so there’s a lot of overlap between the two groups anyway.

Wegovy isn't off label. Talking about WLI's as one drug isn't useful.

There is nothing more delicious than someone like @milkyuniverse getting facts totally wrong, fucking up their point then relentlessly insisting they’re right. It just shows how little they know - and how worthless their opinions and faux concern are.

GLP-1s are NOT off-label. No argument. End.

Fair point. I would imagine more new users are on Wegovy now than was the case before the MJ price hike.

Curious.

For those that take MJ for diabetes, what dose are they on?

Anyone know.

The same as for weight loss. Start at 2.5mg and titrate up as necessary. It will vary from person to person as to what works for them.

And hurling abuse at people who are right and try to explain to them.

Ah right. Thank you.

So the same as for weightloss.

So no argument there then, or the OP needs to include all the diebetics in her list of concerns.

Not to worry though, she's read a fluff magazine article with some plastic surgeons who definitely aren't toting for business, so her credentials aren't in any doubt.