To think it will be revealed WLI cause physical aging

[Tuliptana]

Obviously the pictures of Kelly Osbourne are both sad and terrifying.

But a few women i know have also used this method for weight loss and their skin has lost elasticity. They look at least 10 years older. Is this side effect being under played?

This. People on WLI who are under 35 look young and fresh… because they are.

There are millions of years of patient data for GLP-1s.

i don’t think you’ll be seeing this es court cases you appear to be gleefully anticipating

How about we stop attacking women full stop ? She’s 41 , has battled with eating issues her whole life indoctrinated from her mother and both of them are dealing with the loss of their dad / life long partner. She’s no thinner than most actors / models these days and people need to back off - she’s admitted she is struggling with the grief aspect so why pile on to make her feel worse ? And yes I doubt she will read mumsnet but honestly the constant media criticism must be extremely damaging to her

My internal organs are thanking me!
My heart via reduced blood pressure? Kidneys due to reduced blood pressure. My pancreas as it’s not pounded dealing with sugar and my liver as it’s no longer managing crap!

Flappy skin is a very acceptable side effect when overall general meaningful health is improved.

yep, I’m happy to be in a better position to have longevity to be around, fit and well for my children.

Those women you know would look exactly the same if they’d followed a diet that made them lose weight quickly. It’s not the jabs, it’s the rapid weight loss.

None of that data is long term - how can it be with such new drugs? Nobody has any data for the effects after 10/20 years.

Your medical knowledge is impressive OP 🙄

It's an old drug with a new use.

Yawn.

Just how much is really known about what they are doing to peoples' bodies? I am overweight but would not use them if you paid me. I think nowhere near enough is known about possible side effects.

My hairdresser is obviously using them although she says she is just eating healthily and is starting to look dreadful. Her face is becoming really thin and haggard

People on WLI under a doctor don’t get regular blood tests either. Neither do most Brits on almost all medications.

Been around for years. Of course there is the data. They would never have been licensed if not.

She IS seeing what's being written about her and posted a response on Sunday morning after the BRITs.

What elephant? That people have eating disorders? That people abuse drugs?

I was initially shocked that people who can afford all the support are abusing WLI, but when you reframe it as drugs- well, people always have.

Not true. My hairdresser is under 35 and looks dreadful

Exactly

Was she very obese? Because everyone I know of that age looks exactly the same as before they took them facially.

That's very optimistic of you to think OP actually has any rationale for this, much less is capable of articulating it.

I don't really care about whoever Osborne.

I do care about my friends though....i live in a well off south east village, most of my friends (all in our forties) had size 14/16 "mum bods" and have eagerly found online pharmacies to give them mounjaro. One has yoyo-ed down to a size 6, stopped taking it, piled weight back on incredibly fast & is back on it. Another told me she had a horrendous run of stomach issues when taking it.

I do think at some point the supply to these people will be more strictly regulated, they were barely even overweight let alone obese so this is unlikely to be providing them with health benefits. The "checks" seem to be incredibly easy to lie to get around.

A friend is a doctor doing some specialist research into obesity and said that there are concerns around what WLI drugs do to your own endocrine function, with some people gaining weight more rapidly when they stop taking them. This would worry me a bit - sure you could stay on a "maintenence dose" forever but what will the pharma companies charge you for that?

How are people still so ignorant? The drug has been around for years and there is lots of data. Maybe not decades but plenty to look at. It seems like people are desperate for people to suffer at some point for taking them. Why is that, I wonder.

The Osbornes look a state because they've combined WLI with questionable plastic surgery and not stopped when they reached a good weight.

I'm 47 and lost nearly 5 stone. I look fine but my neck is a bit wrinkly and saggy and my thighs and bum are a bit saggy as well. Better that than still carrying 5 stones around.

@PurpleCoo you are using them in exactly the right way to weight loss down to a healthy weight/BMI alongside weight and strength training

and strength training is vital as it ensures fat loss not muscle loss (and I think is actually stated as being necessary when taking them)

two things are simultaneously true. WLI when used correctly are amazing. When used incorrectly and for too long they are not

and that is the issue - used when either a sensible approach would lose the excess weight or when there was no excess weight to begin with and without the proper dietary and exercise care - people still need a certain amount of nutrition

it is why Victoria Beckham has survived (and her work is commensurate with others) because her diet is fish and vegetables and exercise - and a whole lot of iron willpower

used correctly WLI amazing. Used incorrectly yes it can age you and properly have side effects worse than in they carried 10 extra pounds

I was obese at a size 12… a size 16 is very often firmly obese.

I’m sure Kelly Osbourne will be getting regular blood tests. If there are health effects from use in women who are already low weight then these will already be known.

Probably WLI will have an overall antiaging effect due to its effects on inflammation, but losing weight in any case will make you look older, this would be the case if you lost it the old-fashioned way.

Not that dress size is remotely scientific, but are you quite sure none of your 14-16 friends had a 30 BMI? Because unless they're all pretty tall and/or only wear clothes from retailers who size skimpy, you might be surprised.

Do remember as well that the threshold is 27 if you have a qualifying condition, and women in their 40s often have high cholesterol or blood pressure.

We know that people gain weight more rapidly when they come off them because the data is already there. Reasons being rebound appetite which acts physiologically and psychologically, reduced metabolism due to muscle loss and the physiological effect of obesity on fat cells and hormones. Yes we probably will need to take a maintenance dose long term or most of us anyway. So what? Why does that worry you?