Help! Polynucleotides gone wrong

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Hello

Anyone on here experienced with polynucleotides either as a practitioner or a recipient? Posting here for traffic!

Thanks!

So pleased you resolved it! You look great. Thank you so much for sharing your experience.

I had my last of the 3 treatments in early November. I have had HA fillers in the past in the tear trough but was advised the PN shouldn’t interfere with those. As the swelling is under one eye and this was the eye that bruised really badly after the last PN they have always said the swelling was down to the bruising and it could take months to resolve. I had an eye twitch at the same time for the first 3 months which would suggest something was pressing on a nerve. My other eye still has a hollow which was what I was hoping the PN would help with and nothing has improved on that one. Having one eye hollowed and the other with swelling looks very odd. I’m going to ask for topilase and see if that works or at least try and small injection of hyaluronidase

Thank you for responding. Good luck with the topilase, let us know if you have any good results with it. Hoping we find a solution together, this is extremely frustrating and upsetting.

I am so glad I found this thread as I was thinking about polynucleotide, however,
collectively, you’ve all put me off.

I sincerely mean this, thank you 🐟

Hi I’ve seen my injector yesterday and tried dissolving cream. I’d did nothing. We only held it for r5 min, I’ll try again in a week time for 10 min and see if makes a difference.

I will not touch dissolving as even my rationed says people complain about hollowness under eyes which is not resolved with time and seems to be forever permanent.

I told her about your case and she asked if you had any prolonged swelling initially? Were you swollen up? Also how long ago did you have your HA filler? Which filler was it, do you recall?

Hi,

Can you tell us if your swelling got any better? How are you doing at the moment, have you tried anything to resolve it?

Hi, has your swelling / eye bags gone down? Have you tried anything to resolve? I’m having the same issue and just want to see if it goes away in time and gets better? Would be grace to have an update from you with hopefully good news 🙏

I didn’t have any swelling after the filler no. Had no issues with it at all. Sorry dissolving did nothing for you. I’m seeing a surgeon today to see if he thinks it’s the fat pad. You can test that yourself by closing your eye and pushing on your eyeball a few times which places pressure on the fat pad to pop in and out. Obviously not too hard! If you ask someone to video this you can see if the swelling moves in and out with the eyeball. If it does it could be a swelling in the fat pad which has come from the PN. My surgeon did this to me in the past before deciding to do a lower blepharoplasty to remove the fat pads (fat pads can come back). If my surgeon says it isn’t the fat pad I’m down to fluid from something or filler.

Thank you so much for your response. Did you have any prolonged swelling after the Polynucleotides rounds, not the filler? Please let me know what your surgeon said and if it’s a fat pad. Do you think the eyebag you describing is gradually getting better over these months or do you think it stayed the same? Thank you again

Sorry I don’t seem to be able to reply to particular messages only add a post! Disappointing session with the surgeon. He said it’s not the fat pad and wasn’t offering any opinion. He does work with the injector so it feels like they are both distancing themselves from the issue. He did say it was worth trying to dissolve whatever it is and also trying radio frequency but that’s it. My injector is away for a couple of weeks so I’m going to find someone else to try and dissolve it to see if there’s any change. I didn’t have this swelling with either the filler or PN immediately after treatment. I’m very frustrated with the clinic leaving me to deal with it.

I am so sorry you are going through this as well. So the doctor said it’s not a fat pad? Have they offered you an ultrasound at least to make sure it’s a swelling and not fat? My injector is being helpful but also can’t give me an answer if this will ever go back to pre NT injection. She send my photos to PN manufacturer and they suggested dissolving. I am not sure and would be happy to wait if it’s 6-9 months they say PN effect lasts but if it’s more permanent I would I also like to see what I can do to help the situation. It left me depressed every day I wake up and look at myself in the mirror before I leave the house and realise I look 10 years older due to this, look really tired and I’m going through a breakup at the same time- it’s just extremely upsetting. I’ve read a lot about dissolving injection and there are a lot of negative “help it destroyed my face” reviews than positive ones. It seems a lot of people suffer from tissue damage and hollowness under eyes for years after and the chances are higher especially in women over 40 who go through perimenopause or menopause. I decided to wait and see and try radio frequency but I want to wait doing that also because It’s also collagen boosting and may make that area swell up and flair up again. I just don’t know. Let me know if you do decide to do the dissolving and if it worked for you, my injector says all the bad reviews about dissolving are not true as don’t disclose the full story and she’s done hundreds of dissolving treatments without an issue. She really is adamant it will do it.

I had bio films years ago under my eyes after a reaction to HA filler that was injected too superficially and went undetected for many weeks and I woke up one day and the swelling had turned into hard lumps. I had to have a lot of the dissolving agent to get rid of them along with steroids and antibiotics. It did remove some of my own HA and it never fully came back for me which started the never ending journey of trying to ‘fill’ the indentations left behind. So I am very vary of dissolving again but I would ask them to go very slowly and in very small doses. The ultrasound wasn’t offered after being suggested - they said it wouldn’t necessarily detect old filler. I have bought an LED/microcurrent eye mask to see if that helps. If it’s going to help it will take a month or so. Meanwhile I am going to try both a small amount of dissolver plus im
seeing someone who does lymphatic drainage on Thursday. After that there’s not much more I can try.

Hi, thank you again for your response and for sharing your story. I can imagine how frustrating that must feel! I hope the dissolving will help, and hopefully that will be the end of this nightmare you are going through. I did hear many people say the radio frequency helps, so that may be another thing to try but all of these treatments are so expensive, they add up to thousands of pounds. I had an ultrasound done and they said they can see the oedemas under my eyes but also said the ultrasound wont detect old filler, only MRI scan, which is super expensive. I will keep you posted on my luck, will try to apply the dissolving cream tomorrow, microneedle it with a roller tomorrow and wait for longer than first time, I will repeat this in a week time - I am really hoping it will help bit by bit, plus the time.

I understand your distress and frustration. Spending thousands potentially to put right something you were told was safe and couldn’t have these side effects and only cost a few hundred is horrible. I feel I’m running out of options. Lymphatic drainage was today and I can’t see any difference and they did say that they couldn’t guarantee it would work. I usually use a derma stamp on my face but didn’t feel the head was small enough to get to the right place under the eye so I’ve invested in a Dr Pen which should be easier to use and target the right area. I was told by the aesthetics salon I go to for peels that microneedling will help break down the HA in the PN so like you am trying that route first. As a last resort I’ll try dissolving. Im
at 6 months now with no improvement as yet. I use a product daily called Dr Brandt Needles no more which temporarily tightens the skin under the eye. Once you get used to applying it, it does mask some of the swelling so perhaps try something like this? Keep in touch!

Thank you so much for keeping me updated, It’s really frustrating. Do you know anyone who is suffering with this for months, could this be permanent? Not a lot of information online, I can’t find any cases on more that 4-5 months old which makes me believe it does resolve itself with time? Im
hopefull… Micro-needling could help but im worried of making it worse with anything now! Let me know how it goes for you, we keep in touch.

I’ve not seen anyone else at 6 months in but that might just mean they got it resolved and we’ve yet to find our path. There are always solutions so I think we just have to find ours. Microneedling can’t do any harm and is good for our skin generally so it’s worth a go. For me I know I won’t touch polynucleotides again.

Hi I completely agree! I will not touch polynucleotides also. Too little benefit if it works and too big of a mess up if it doesn’t. I will keep you posted on my progress. I will keep trying topalise, will give it at least 4 x rounds as people say sometimes it works on the 3/4 time but I’m not too optimistic. Let’s speak in a couple of weeks time, hopefully we have some good news!

Hi ladies, just to say. I had the injectable dissolve a couple of weeks ago now. I hadn’t noticed any downside and immediate improvement. I did have slightly dehydrated skin for a week but it did bounce back and the lines around my eyes when smiling are back to pre treatment/dissolve with plenty of hydration and topical moisturiser. I genuinely believe it’s the only thing that will get rid of it completely and so glad I did it. Good luck 🤞

VHL- how bad were your before dissolving? Would you put a before and after photo on or at least message me with these? I’m struggling to get agreement to trying to dissolve but being able to share others before and after a might help.

Hi, I had posted a before and after but had to ask the admin team to take it down as you can’t delete it yourself and didn’t want it lingering on here. I tried sending another lady the picture directly but it wouldn’t allow me to. Not sure it lets you send messages with pictures or I would happily. When I was googling desperate to find a solution I found this study/article where they showed dissolve helps with swelling that either occurs naturally or with PN etc. so I showed another aesthetics nurse and she agreed. It worked immediately.

https://eurjmedres.biomedcentral.com/articles/10.1186/2047-783X-19-30

Mine were awful, looked like I had been punched hard under both eyes, the swelling was so prominent it stood away from my face. I don’t know what area you are from but I used a nurse called Carley at a clinic in Bexley Kent called synergy

After my experience, I certainly wouldn’t want any more!

I have had 6 year old filler removed, two sessions with two different surgeons, the second one most recently. Can’t comment on the polynucleotides BUT in terms of hyaluronaise I would suggest to only see an ocular surgeon if you can. I was scanned both times and a minimal amount was injected. I now have the same under eye hollows that led me down the filler route. I’m 50 so there might be a tiny bit more crepeyness but I expected that. I would also say that some surgeons are more honest than others on what to expect from the aesthetic market.
Same can be said for (most) of the aesthetic nurses and aesthetic doctors I’ve seen, sadly. I personally wouldn’t touch fillers again and I don’t think pn’s have been on the market long enough to be injected in to our faces.
I hope you can find a solution.

Joining in on this thread! I had 3rd round of poly back in December and a week later I had huge eye bags appear which weren’t there before. I went back and the lady administered PRP under my eyes, we did this on multiple occasions, I also did lymphatic drainage and nothing works. The eye bags are still there and my eyes are much darker than before. It’s made me so self conscious so I know how you all feel! It’s so odd because the first two rounds of it my eyes were totally fine I had no issues at all. After reading some comments on here and doing some research I’m going back to my lady this week and she’s going to micro dose hyaluronidase. I hoping that works! I will keep you updated