There are around 1100 identified genes (so far) that are known to be associated with obesity. Some people have few of them, some have many. The complex gut-brain axis and weight set-point results in long term maintenance of significant weight loss in obese people from diet and exercise alone being almost impossible. Only 3% of obese people who lose a significant amount of weight are able to keep it off long term. In 97% of cases the weight is regained, so "Eat less, move more" sounds nice and simple on paper, but the truth is that it simply is not an effective treatment for the vast majority of obese people.
If you are someone who is genetically and psychologically predisposed to obesity, then the urge to eat, food seeking behaviours and insatiable hunger can be absolutely uncontrollable, and the amount of self control that is required to lose and maintain weight loss is beyond what it is possible to sustain in the long term.
I am someone who feels very fortunate to be naturally predisposed to be a healthy weight, but I know I absolutely do not have greater self discipline or self control than someone who is predisposed to obesity. I simply don't need it, as my hunger levels, and urge to eat are at normal and controllable levels, which allows me to make healthy choices. It is in no way an even playing field, and I'm very aware with just a few different genes I would no longer have that control.
These new drugs are absolutely life changing for many people. I'm a GP, and while I cannot yet prescribe GLP-1s for obesity, I have many patients who have been taking private prescriptions for Wegovy and Mounjaro and have told me their stories. So many of these marvel at the loss of the "food noise" that they have been plagued by throughout their lives, and have found simply being able to live their lives and think about other things, without thoughts of food and eating encroaching upon everything they do to be immensely freeing, quite apart from the weight loss itself. I think these drugs are going to be absolutely revolutionary for patients living with obesity and very much hope they become available in time to patients who cannot afford expensive private prescriptions.