Your DD sounds amazing op, not only coping well with the circumstances she was left with after being very badly let down by 2 people she presumably loved and trusted but happy with that. She could be eaten up with discontent and resentment but she's not she's giving the two most important people in her life an amazing stable loving home.
I bet she does know how you feel, those questions like 'why don't you get a qualification and do something else' asked again despite the answer, give it away.
You've never said to her (judging by your posts) the above question added with '... If you'd like to do that and need help - that lets face it isn't easily available - I'll help with (the greatest thing standing in her way of that) the children'
Despite the fact as you said, you and your DH are both professionals, no other children, so presumably could afford to step back if you choose to do so... But you are as completely and firmly wedded to your personal priorities to the exclusion of any other consideration as she is! Because you won't give that up even though you really would like to see her make another choice. She isn't asking you to, but even if she was, the answer would be no wouldn't it, so your work comes before her, every time, no matter what.
The upbringing she had, lacked in important respects in her experience and she is determined (very driven and committed 💪) not to do that to the two people she has created... A commendable attitude. She is committed to her priorities and that commitment is in part so strong because of the experiences she had that you gave her. She told you she isn't repeating that and putting her children what she went through.
(Her upbringing might have been fine for some children but it wasn't fine for her).
So actually though you are riddled with disappointment in her, and sad to see her wasted potential as you see it, you wouldn't actually bend your life out of shape to make any alternative possible, even though you'd really like to see that happen.
I think you are more bothered about your own social status when these other high flyers are talked about, and anyway, whatever you are bothered about, your career is still the most important thing, so I think you need to let it go, truly, deeply and genuinely find a way to stop thinking 'she's doing a great job but...'
The hard part to getting there is that you deem a high flying career as the pinnacle of a life will lived, so reconciling that with recognising the real worth of other kinds of life is going to be tough for you.
So many children are created and then considered 'in the way' of their parents other wishes for life... Or neglected because parents aren't coping or... The list goes on... How fantastic your DD's children are so beautifully cared for. I hope you give her all the practical support you can to give her a break sometimes.