Alcohol and coke are deadly when used together.
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One of the most dangerous effects of combining cocaine with alcohol is the production of cocaethylene in your liver. When you ingest harmful substances, your body removes them from your bloodstream and sends them to your liver so you can metabolize them out of your system safely.
On their own, both alcohol and cocaine can take hours or even days to metabolize out of your body.
When the two drugs are metabolized together, a substance called cocaethylene is produced in the liver as a result of the cocaine being altered in the presence of alcohol.
This new substance is more dangerous than alcohol or cocaine on its own and can take a long time to eliminate from your body.
Research has shown that cocaethylene is produced in the liver roughly two hours after you’ve ingested both drugs, (Source: Science Direct) and that about 20 percent of the cocaine your liver attempts to metabolize is disrupted by alcohol, producing cocaethylene.
From there, when your liver tries to eliminate the cocaethylene, the alcohol that’s still in your system slows down the process.
If you continue to drink alcohol, your body continues to struggle to eliminate cocaethylene and it passes from the liver into your bloodstream.
There, it can have detrimental effects on your tissues and organs and can produce intoxicating effects much more powerful than cocaine or alcohol can alone.
What are the Dangers of Cocaethylene?
Cocaethylene enhances the euphoric effects associated with both alcohol and cocaine. However, this also means you may experience an increase in blood pressure, impulsive and even violent behavior, and poor judgment. Worse yet, cocaethylene is far more toxic than cocaine or alcohol and can build toxic levels in the liver.
This can ultimately result in sudden, sometimes fatal, overdose.
Once your liver has begun producing cocaethylene, you may experience one or more of the following dangerous consequences:
Increased risk for heart attack and stroke: Cocaethylene raises your heart rate and blood pressure more than cocaine alone does and impairs your heart’s ability to contract. Studies show cocaethylene increases your risk of heart attack and stroke more than alcohol or cocaine alone.
Increased alcohol consumption: The production of cocaethylene has been linked to binge drinking. This can cause strain on your body, such as liver damage, nerve damage, and alcohol poisoning.
Higher levels of toxicity: Cocaethylene is up to 30 percent more toxic than cocaine and stays in your system up to three times longer. This increases your chance of experiencing toxic effects, such as overdose or death.
Increased risk for drug abuse: Because combining alcohol and cocaine tempers the negative side effects, you might feel from each, it encourages you to continue using both drugs. Cocaethylene also blocks your brain’s reuptake of dopamine, which heightens the high you feel and may increase your cravings for both substances.
Can Mixing Alcohol and Cocaine Result in Overdose?
Yes, mixing alcohol and cocaine can result in an overdose. On their own, you can consume enough of either substance to result in death.
When you combine the two, you often can’t tell how impaired you are and will continue to use one or both substances excessively, at which point you may overdose.
In addition, using cocaine and alcohol together is the substance combination most highly associated with drug-related deaths. Not only does combining these substances increase your risk of overdose, but it’s also been associated with suicide and accidental deaths from risky behavior. Studies have found that people are more likely to complete a suicide attempt when alcohol and cocaine are both present in the blood. More.