I used to have one in a former house, don't anymore. I like a decent person: bathroom ratio, but was not a big fan of the en suite. As a pp said, I'd have preferred more storage space. The smell from DH was horrible (not to mention him not closing the door when having a poo so it used to be right in front of me in bed), the bedroom windows would get steamed up, when we worked different shifts it would wake up the sleeping partner.
At uni, I had a bedroom - dressing room - bathroom set up. That was great. Plus I was living alone so none of the noise or smell elements were an issue.
In answer to a pp, yes, I'm not hugely enamoured of en suites on holiday either, but I will put up with them as the better than a shared bathroom in a hotel! I usually stay in studios/appartments/houses with a separate bathroom. Hotels are only for 1 or 2 night stays in extremis.
And in answer to another pp, plenty of people go to the loo at more or less the same time every day, whether straight before bed or another time. I don't personally, but I used to lift share into work with 3 people who all did. It came up in conversation when one of the guys apologised for being late because his morning poo had been off schedule.