If you have a high paying job in the South East - because that's what the pay levels are down there because of living costs etc - and your job can be done at home, then your job can be done in other parts of the UK for someone who will do it just as well but for less money.
There may be occasional commuting on the train - but I am sure that could be incorporated into a reasonable package.
The cost of living is much cheaper in many places in the UK compared to the South East.