Brexit, fucking shit fest of epic proportions! I didn't vote for it, and neither did most of the people I know (very few of whom have gone through higher education and who are working class, so the sneery twats saying it was only well educated middle class people who voted Remain can fuck off too.)
Fucking Tories! Especially you, Rees-Mogg, You're a Cunt with a capital C!
Donald Trump and the nightmare that is American politics at the moment, he can fuck right off!
Religious fundamentalists, they piss me off no end. 
On a more personal level, judge-y twats. "Why are you dressed like that? What on earth have you got on your face? How can you still like Harry Potter when you're 30? Why do you listen to such depressing music? What have you got to be depressed about? Etc, etc...
FUCK. OFF! I've got this less as I've got older (minus the HP stuff,) but on the rare times this still happens, were it not for rigorous gun control, I'd be reaching for the AK-47. A slight overreaction, mayhap, but you know how it is. And sometimes people don't need to say anything, they just give you The Look, and you know they're judging you (especially when I go to church, I get The Look there a lot. I also once got into an argument with someone who thinks Evanescence and Amy Lee especially are scary. Fucking hell. I'm sure her four year old son thinks she's terrifying, not. Unless she's telling him off, possibly. I digress...)
I suppose that's another thing that I wish would get tae fuck, people who think the music I listen to is depressing, or weird, or scary, or what the fuck ever. Get a life. Is it affecting you? No. Am I forcing you to listen to it? No. Good, now fuck off. Yes, my favourite band is the one with the weird Goth chick who sang 'Wake me up inside'. (Although you could at least try and get the song title right, you muppet.) They've also moved on quite a bit and have done three albums since the one with that song, and Amy Lee doesn't look the same as she did 15 years ago (does anyone?) Grrr. (Diss Evanescence, and prepare to die.)
On the other hand, you have snotty Goths and metalheads who sneer at my taste in music, or my style. They are thankfully rare, but annoying.
Phew, was was cathartic!