Beyond the biological sex issue there is the question of "specialness".
Are you having to treat some staff with kid gloves, simply because they might use the power that comes with their status. If you challenge their demands, as as NHS Fife should have done, are you opening yourself up to complaint and who is watching your back?
It is the "bring your whole self to work" idea. Many/most people would prefer that their colleagues turned up and did the job without add ons. They don't care about their colour, religion, sexual orientation or gender identity. They want to work with team players to contribute their share. They are happy that there are suitable adjustments for disability or pregnancy and indeed that there is a disabled toilet. They are also happy to acknowledge Chinese New Year and Ramadan, and to make every effort to be sensitive to colleagues diverse backgrounds, and would be quick to support colleagues if there were any obvious discrimination. However at the end of the day it is a job and you expect your colleagues to get on with it, without them keeping notes of minor and perceived slights from a number of colleagues.
A friend has a new colleague, a recent graduate, in their team. This colleague is non-binary (born female.) There was a certain amusement when the NB would correct the Head of Department, someone in their 60s, for using their official name not their NB name. Even established employees are careful about how they phrase any work related disagreement, and do not expect to share anything personal. Those closer in level to the NB would try to fit in with their they/them preferences but are liable to forget when things are busy. The NB is now three months in and a few concerns that have come up that the Head of Department would normally raise to reinforce what has been said by the line manager, in order to help the NBs professional development. However it has become clear that the Head of Department is not going there, thereby making it difficult for the line manager to manage effectively. The graduate will move on in a few months and will become someone else's problem. Without the full career learning that they should have gained in their current position, and without gaining the colleagues and contacts that would provide immediate support, and which might prove useful in the future.
Some of it seems to be about control. A perfectly sweet but slightly anxious young woman, because of her status, can exert control over more senior colleagues. A narcissistic man with a fetish can do similar. Many of us will have come across instances where others have abused their "special" status to gain advantage in the work place. Beth might well have made a good doctor if proper boundaries (use of changing facilities, not treating patients who ask to see a female doctor etc) had been imposed from the start.