If JLC does have a DSD then it didn't stop her taking roles where she wore just underwear. Maybe she struggled with fertility for other reasons and that's why she adopted her children but if she does have a DSD she is an example of how it didn't hold her back.
I found it odd that she gives adds the surname to Annie but not to Ruby in a speech made after appearing with both her children on the red carpet:
"I am proud to be the wife of Christopher Guest. I am so proud to be the parent of Annie Guest and Ruby, and I'm really proud to be a friend to so many people who share everything with me: good, bad, hard, soft, joyful, tragic. Because that's the beautiful part of life."
Read More: www.thelist.com/715043/everything-we-know-about-jamie-lee-curtis-daughter-annie/